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• W4366237417 startingPage "1727" @default.
• W4366237417 abstract "Abstract: The chronic infection of the hepatitis B virus (CHB) represents a major public health problem worldwide. Despite the availability of an effective prophylactic vaccine, millions of hepati-tis B patients are at increased risk of developing chronic liver disease. The currently available treatments for HBV infection include interferon and nucleos(t)ide analogues that are effective at suppressing viral load and preventing or delaying the progression of liver disease. However, these treatments offer somewhat unsatisfactory clinical cures due to the persistence of the intrahepatic pool of covalently closed circular DNA (cccDNA) that serves as a reservoir for viral progenies and a potential source of recurring infections. Elimination of viral cccDNA remains a challenge for sci-entists and pharmaceutical industries in order to achieve the eradication and control of HBV infec-tion. This would involve a detailed understanding of the molecular mechanisms of cccDNA for-mation, its intracellular stability, and regulation during replication and transcription. Recent ad-vances in drug therapy have heralded a new horizon of novel therapeutic approaches for CHB infec-tion, with several promising antiviral and immunomodulatory agents currently in preclinical or clin-ical testing. However, approval of any new curative therapy would involve rigorous evaluation of the efficacy and safety of each treatment and defining correct endpoints associated with improved clinical outcomes. This article summarizes the current landscape of HBV treatments, and drugs in clinical trials and highlights the most recent anti-HBV small molecules designed to directly target HBV or to improve immune response during chronic infection." @default.
• W4366237417 created "2023-04-20" @default.
• W4366237417 creator A5031512242 @default.
• W4366237417 creator A5033955085 @default.
• W4366237417 creator A5076478528 @default.
• W4366237417 date "2023-08-07" @default.
• W4366237417 modified "2023-09-27" @default.
• W4366237417 title "Chronic Hepatitis B Infection: Current and Emerging Therapeutic Strategies" @default.
• W4366237417 cites W1506669191 @default.
• W4366237417 cites W1536758910 @default.
• W4366237417 cites W1543067125 @default.
• W4366237417 cites W1939458592 @default.
• W4366237417 cites W1966393716 @default.
• W4366237417 cites W1974999149 @default.
• W4366237417 cites W1977559293 @default.
• W4366237417 cites W1978329469 @default.
• W4366237417 cites W1979369583 @default.
• W4366237417 cites W1986388698 @default.
• W4366237417 cites W1988761020 @default.
• W4366237417 cites W1990487307 @default.
• W4366237417 cites W1999770898 @default.
• W4366237417 cites W2004139194 @default.
• W4366237417 cites W2005049682 @default.
• W4366237417 cites W2006774237 @default.
• W4366237417 cites W2007016356 @default.
• W4366237417 cites W2007423548 @default.
• W4366237417 cites W2009127910 @default.
• W4366237417 cites W2010185867 @default.
• W4366237417 cites W2016995625 @default.
• W4366237417 cites W2017733846 @default.
• W4366237417 cites W2027280548 @default.
• W4366237417 cites W2029687799 @default.
• W4366237417 cites W2031489362 @default.
• W4366237417 cites W2032063600 @default.
• W4366237417 cites W2033492998 @default.
• W4366237417 cites W2036742637 @default.
• W4366237417 cites W2040562731 @default.
• W4366237417 cites W2042692189 @default.
• W4366237417 cites W2044951291 @default.
• W4366237417 cites W2046828081 @default.
• W4366237417 cites W2050607746 @default.
• W4366237417 cites W2058376942 @default.
• W4366237417 cites W2061543400 @default.
• W4366237417 cites W2063137497 @default.
• W4366237417 cites W2076506726 @default.
• W4366237417 cites W2079006974 @default.
• W4366237417 cites W2079916692 @default.
• W4366237417 cites W2083967761 @default.
• W4366237417 cites W2089108066 @default.
• W4366237417 cites W2093055973 @default.
• W4366237417 cites W2111625427 @default.
• W4366237417 cites W2112436801 @default.
• W4366237417 cites W2115504968 @default.
• W4366237417 cites W2118406741 @default.
• W4366237417 cites W2120426460 @default.
• W4366237417 cites W2121618290 @default.
• W4366237417 cites W2123781724 @default.
• W4366237417 cites W2127949912 @default.
• W4366237417 cites W2129923672 @default.
• W4366237417 cites W2130575875 @default.
• W4366237417 cites W2150456870 @default.
• W4366237417 cites W2151206652 @default.
• W4366237417 cites W2152095262 @default.
• W4366237417 cites W2156015715 @default.
• W4366237417 cites W2158721163 @default.
• W4366237417 cites W2158728342 @default.
• W4366237417 cites W2224436307 @default.
• W4366237417 cites W2230010802 @default.
• W4366237417 cites W2247430603 @default.
• W4366237417 cites W2290831170 @default.
• W4366237417 cites W2293495463 @default.
• W4366237417 cites W2294472239 @default.
• W4366237417 cites W2323719395 @default.
• W4366237417 cites W2336184200 @default.
• W4366237417 cites W2338985227 @default.
• W4366237417 cites W2398313845 @default.
• W4366237417 cites W2409117115 @default.
• W4366237417 cites W2416193592 @default.
• W4366237417 cites W2429852859 @default.
• W4366237417 cites W2468014476 @default.
• W4366237417 cites W2509537204 @default.
• W4366237417 cites W2512857074 @default.
• W4366237417 cites W2513450606 @default.
• W4366237417 cites W2518924844 @default.
• W4366237417 cites W2552251488 @default.
• W4366237417 cites W2567500175 @default.
• W4366237417 cites W2570651242 @default.
• W4366237417 cites W2595717178 @default.
• W4366237417 cites W2611427234 @default.
• W4366237417 cites W2612582321 @default.
• W4366237417 cites W2613239025 @default.
• W4366237417 cites W2623223454 @default.
• W4366237417 cites W2755250741 @default.
• W4366237417 cites W2766060653 @default.
• W4366237417 cites W2779389699 @default.
• W4366237417 cites W2793638189 @default.
• W4366237417 cites W2796154244 @default.
• W4366237417 cites W2890832308 @default.

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