FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366238949> ?p ?o ?g. }

• W4366238949 endingPage "1083" @default.
• W4366238949 startingPage "1077" @default.
• W4366238949 abstract "Objective: To evaluate the impact of sacubitril/valsartan on blood pressure (BP), ventricular structure, and myocardial fibrosis compared with valsartan in perimenopausal hypertensive women. Methods: This prospective, randomized, actively controlled, open-label study included 292 women with perimenopausal hypertension. They were randomly divided into two groups: sacubitril/valsartan 200 mg once daily and valsartan 160 mg once daily for 24 weeks. The relevant indicators of ambulatory BP, echocardiography, and myocardial fibrosis regulation were assessed at baseline and at 24 weeks. Results: The 24-h mean SBP after 24 weeks of treatment was 120.08 ± 10.47 mmHg in the sacubitril/valsartan group versus 121.00 ± 9.76 mmHg in the valsartan group ( P = 0.457). After 24 weeks of treatment, there was no difference in central SBP between the sacubitril/valsartan and valsartan groups (117.17 ± 11.63 versus 116.38 ± 11.58, P = 0.568). LVMI in the sacubitril/valsartan group was lower than that in the valsartan group at week 24 ( P = 0.009). LVMI decreased by 7.23 g/m 2 from the baseline in the sacubitril/valsartan group and 3.70 g/m 2 in the valsartan group at 24 weeks ( P = 0.000 versus 0.017). A statistically significant difference in LVMI between the two groups was observed at 24 weeks after adjusting for the baseline LVMI ( P = 0.001). The levels of α-smooth muscle actin (α-SMA), connective tissue growth factor (CT-GF) and transforming growth factor-β (TGF-β) were reduced in the sacubitril/valsartan group compared with the baseline ( P = 0.000, 0.005, and 0.000). LVMI between the two groups was statistically significant at 24 weeks after correcting for confounding factors 24-h mean SBP and 24-h mean DBP ( P = 0.005). The LVMI, serum TGF-β, α-SMA, and CT-GF remained statistically significant between the two groups after further correcting the factors of age, BMI, and sex hormone levels ( P < 0.05). Conclusion: Sacubitril/valsartan could reverse ventricular remodeling more effectively than valsartan. The different effects of these two therapies on ventricular remodeling in perimenopausal hypertensive women might be because of their different effects on the down-regulation of fibrosis-related factors." @default.
• W4366238949 created "2023-04-20" @default.
• W4366238949 creator A5019243350 @default.
• W4366238949 creator A5031773278 @default.
• W4366238949 creator A5032652571 @default.
• W4366238949 creator A5060792316 @default.
• W4366238949 creator A5061982597 @default.
• W4366238949 creator A5088339142 @default.
• W4366238949 date "2023-04-17" @default.
• W4366238949 modified "2023-10-14" @default.
• W4366238949 title "Effect of sacubitril/valsartan or valsartan on ventricular remodeling and myocardial fibrosis in perimenopausal women with hypertension" @default.
• W4366238949 cites W1993415261 @default.
• W4366238949 cites W2032130572 @default.
• W4366238949 cites W2035822743 @default.
• W4366238949 cites W2042668756 @default.
• W4366238949 cites W2044241375 @default.
• W4366238949 cites W2174618156 @default.
• W4366238949 cites W2335619666 @default.
• W4366238949 cites W2546645949 @default.
• W4366238949 cites W2587590725 @default.
• W4366238949 cites W2733280136 @default.
• W4366238949 cites W2750808153 @default.
• W4366238949 cites W2762821755 @default.
• W4366238949 cites W2787201390 @default.
• W4366238949 cites W2793955071 @default.
• W4366238949 cites W2884840527 @default.
• W4366238949 cites W2887094893 @default.
• W4366238949 cites W2894839648 @default.
• W4366238949 cites W2900330183 @default.
• W4366238949 cites W2941792662 @default.
• W4366238949 cites W2966258804 @default.
• W4366238949 cites W3043390187 @default.
• W4366238949 cites W3056688886 @default.
• W4366238949 cites W3120115072 @default.
• W4366238949 cites W3126955501 @default.
• W4366238949 cites W3128340637 @default.
• W4366238949 cites W3134939470 @default.
• W4366238949 cites W3156828093 @default.
• W4366238949 cites W3157669632 @default.
• W4366238949 cites W4295990640 @default.
• W4366238949 doi "https://doi.org/10.1097/hjh.0000000000003430" @default.
• W4366238949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37071432" @default.
• W4366238949 hasPublicationYear "2023" @default.
• W4366238949 type Work @default.
• W4366238949 citedByCount "1" @default.
• W4366238949 countsByYear W43662389492023 @default.
• W4366238949 crossrefType "journal-article" @default.
• W4366238949 hasAuthorship W4366238949A5019243350 @default.
• W4366238949 hasAuthorship W4366238949A5031773278 @default.
• W4366238949 hasAuthorship W4366238949A5032652571 @default.
• W4366238949 hasAuthorship W4366238949A5060792316 @default.
• W4366238949 hasAuthorship W4366238949A5061982597 @default.
• W4366238949 hasAuthorship W4366238949A5088339142 @default.
• W4366238949 hasBestOaLocation W43662389491 @default.
• W4366238949 hasConcept C126322002 @default.
• W4366238949 hasConcept C164705383 @default.
• W4366238949 hasConcept C2775999527 @default.
• W4366238949 hasConcept C2776754050 @default.
• W4366238949 hasConcept C2777387769 @default.
• W4366238949 hasConcept C71924100 @default.
• W4366238949 hasConcept C84393581 @default.
• W4366238949 hasConceptScore W4366238949C126322002 @default.
• W4366238949 hasConceptScore W4366238949C164705383 @default.
• W4366238949 hasConceptScore W4366238949C2775999527 @default.
• W4366238949 hasConceptScore W4366238949C2776754050 @default.
• W4366238949 hasConceptScore W4366238949C2777387769 @default.
• W4366238949 hasConceptScore W4366238949C71924100 @default.
• W4366238949 hasConceptScore W4366238949C84393581 @default.
• W4366238949 hasIssue "7" @default.
• W4366238949 hasLocation W43662389491 @default.
• W4366238949 hasLocation W43662389492 @default.
• W4366238949 hasLocation W43662389493 @default.
• W4366238949 hasLocation W43662389494 @default.
• W4366238949 hasOpenAccess W4366238949 @default.
• W4366238949 hasPrimaryLocation W43662389491 @default.
• W4366238949 hasRelatedWork W2776335933 @default.
• W4366238949 hasRelatedWork W2904992990 @default.
• W4366238949 hasRelatedWork W2914028752 @default.
• W4366238949 hasRelatedWork W3127460900 @default.
• W4366238949 hasRelatedWork W3152772598 @default.
• W4366238949 hasRelatedWork W3188325112 @default.
• W4366238949 hasRelatedWork W3195938057 @default.
• W4366238949 hasRelatedWork W4210976596 @default.
• W4366238949 hasRelatedWork W4235888460 @default.
• W4366238949 hasRelatedWork W4323356027 @default.
• W4366238949 hasVolume "41" @default.
• W4366238949 isParatext "false" @default.
• W4366238949 isRetracted "false" @default.
• W4366238949 workType "article" @default.