Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366239916> ?p ?o ?g. }
- W4366239916 abstract "Proinflammatory agonists provoke the expression of cell surface adhesion molecules on endothelium in order to facilitate leukocyte infiltration into tissues. Rigorous control over this process is important to prevent unwanted inflammation and organ damage. Protein L-isoaspartyl O-methyltransferase (PIMT) converts isoaspartyl residues to conventional methylated forms in cells undergoing stress-induced protein damage. The purpose of this study was to determine the role of PIMT in vascular homeostasis. PIMT is abundantly expressed in mouse lung endothelium and PIMT deficiency in mice exacerbated pulmonary inflammation and vascular leakage to LPS(lipopolysaccharide). Furthermore, we found that PIMT inhibited LPS-induced toll-like receptor signaling through its interaction with TNF receptor-associated factor 6 (TRAF6) and its ability to methylate asparagine residues in the coiled-coil domain. This interaction was found to inhibit TRAF6 oligomerization and autoubiquitination, which prevented NF-κB transactivation and subsequent expression of endothelial adhesion molecules. Separately, PIMT also suppressed ICAM-1 expression by inhibiting its N-glycosylation, causing effects on protein stability that ultimately translated into reduced EC(endothelial cell)-leukocyte interactions. Our study has identified PIMT as a novel and potent suppressor of endothelial activation. Taken together, these findings suggest that therapeutic targeting of PIMT may be effective in limiting organ injury in inflammatory vascular diseases." @default.
- W4366239916 created "2023-04-20" @default.
- W4366239916 creator A5005794101 @default.
- W4366239916 creator A5016848836 @default.
- W4366239916 creator A5020161414 @default.
- W4366239916 creator A5023972117 @default.
- W4366239916 creator A5034547272 @default.
- W4366239916 creator A5049797241 @default.
- W4366239916 creator A5062519157 @default.
- W4366239916 creator A5065484323 @default.
- W4366239916 creator A5069489291 @default.
- W4366239916 creator A5069971376 @default.
- W4366239916 creator A5071919868 @default.
- W4366239916 creator A5080757739 @default.
- W4366239916 date "2023-04-18" @default.
- W4366239916 modified "2023-10-18" @default.
- W4366239916 title "PIMT is a novel and potent suppressor of endothelial activation" @default.
- W4366239916 cites W1504914687 @default.
- W4366239916 cites W1568582789 @default.
- W4366239916 cites W1600472471 @default.
- W4366239916 cites W1929659759 @default.
- W4366239916 cites W1944789189 @default.
- W4366239916 cites W1967098315 @default.
- W4366239916 cites W1967790997 @default.
- W4366239916 cites W1972653445 @default.
- W4366239916 cites W1975201485 @default.
- W4366239916 cites W1985171924 @default.
- W4366239916 cites W1988678004 @default.
- W4366239916 cites W2004465286 @default.
- W4366239916 cites W2006035377 @default.
- W4366239916 cites W2006502788 @default.
- W4366239916 cites W2007027096 @default.
- W4366239916 cites W2008680963 @default.
- W4366239916 cites W2011230502 @default.
- W4366239916 cites W2016146035 @default.
- W4366239916 cites W2019166246 @default.
- W4366239916 cites W2030740278 @default.
- W4366239916 cites W2031797010 @default.
- W4366239916 cites W2032972084 @default.
- W4366239916 cites W2037454778 @default.
- W4366239916 cites W2037672200 @default.
- W4366239916 cites W2043801813 @default.
- W4366239916 cites W2046764302 @default.
- W4366239916 cites W2056402897 @default.
- W4366239916 cites W2056565413 @default.
- W4366239916 cites W2061016075 @default.
- W4366239916 cites W2063015454 @default.
- W4366239916 cites W2063559096 @default.
- W4366239916 cites W2072787000 @default.
- W4366239916 cites W2072932481 @default.
- W4366239916 cites W2074508734 @default.
- W4366239916 cites W2081477919 @default.
- W4366239916 cites W2099675490 @default.
- W4366239916 cites W2108868980 @default.
- W4366239916 cites W2113355655 @default.
- W4366239916 cites W2116101489 @default.
- W4366239916 cites W2128148038 @default.
- W4366239916 cites W2131496660 @default.
- W4366239916 cites W2135919238 @default.
- W4366239916 cites W2136969158 @default.
- W4366239916 cites W2142687288 @default.
- W4366239916 cites W2146047003 @default.
- W4366239916 cites W2147005308 @default.
- W4366239916 cites W2154758223 @default.
- W4366239916 cites W2155304716 @default.
- W4366239916 cites W2156066970 @default.
- W4366239916 cites W2157160136 @default.
- W4366239916 cites W2169384786 @default.
- W4366239916 cites W2170107603 @default.
- W4366239916 cites W2171783221 @default.
- W4366239916 cites W2224499788 @default.
- W4366239916 cites W2291307835 @default.
- W4366239916 cites W2402841042 @default.
- W4366239916 cites W2581605534 @default.
- W4366239916 cites W2593262554 @default.
- W4366239916 cites W2620241325 @default.
- W4366239916 cites W2739174192 @default.
- W4366239916 cites W2762013385 @default.
- W4366239916 cites W2766221641 @default.
- W4366239916 cites W2803941007 @default.
- W4366239916 cites W2897108882 @default.
- W4366239916 cites W2946385077 @default.
- W4366239916 cites W2970989334 @default.
- W4366239916 cites W3020644521 @default.
- W4366239916 cites W3034404517 @default.
- W4366239916 cites W3043796081 @default.
- W4366239916 cites W4210953040 @default.
- W4366239916 cites W4313347899 @default.
- W4366239916 doi "https://doi.org/10.7554/elife.85754" @default.
- W4366239916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37070640" @default.
- W4366239916 hasPublicationYear "2023" @default.
- W4366239916 type Work @default.
- W4366239916 citedByCount "0" @default.
- W4366239916 crossrefType "journal-article" @default.
- W4366239916 hasAuthorship W4366239916A5005794101 @default.
- W4366239916 hasAuthorship W4366239916A5016848836 @default.
- W4366239916 hasAuthorship W4366239916A5020161414 @default.
- W4366239916 hasAuthorship W4366239916A5023972117 @default.
- W4366239916 hasAuthorship W4366239916A5034547272 @default.
- W4366239916 hasAuthorship W4366239916A5049797241 @default.