Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366240178> ?p ?o ?g. }
- W4366240178 abstract "Muscular dystrophies make up a group of genetic neuromuscular disorders that involve severe muscle wasting. TGF-β-activated kinase 1 (TAK1) is an important signaling protein that regulates cell survival, growth, and inflammation. TAK1 has been recently found to promote myofiber growth in the skeletal muscle of adult mice. However, the role of TAK1 in muscle diseases remains poorly understood. In the present study, we have investigated how TAK1 affects the progression of dystrophic phenotype in the mdx mouse model of Duchenne muscular dystrophy (DMD). TAK1 is highly activated in the dystrophic muscle of mdx mice during the peak necrotic phase. While targeted inducible inactivation of TAK1 inhibits myofiber injury in young mdx mice, it results in reduced muscle mass and contractile function. TAK1 inactivation also causes loss of muscle mass in adult mdx mice. By contrast, forced activation of TAK1 through overexpression of TAK1 and TAB1 induces myofiber growth without having any deleterious effect on muscle histopathology. Collectively, our results suggest that TAK1 is a positive regulator of skeletal muscle mass and that targeted regulation of TAK1 can suppress myonecrosis and ameliorate disease progression in DMD." @default.
- W4366240178 created "2023-04-20" @default.
- W4366240178 creator A5022184500 @default.
- W4366240178 creator A5024469424 @default.
- W4366240178 creator A5030189037 @default.
- W4366240178 creator A5077366004 @default.
- W4366240178 creator A5078552586 @default.
- W4366240178 creator A5087234088 @default.
- W4366240178 creator A5090043278 @default.
- W4366240178 date "2023-05-22" @default.
- W4366240178 modified "2023-10-18" @default.
- W4366240178 title "Targeted regulation of TAK1 counteracts dystrophinopathy in a DMD mouse model" @default.
- W4366240178 cites W1600472471 @default.
- W4366240178 cites W1850477203 @default.
- W4366240178 cites W1968854849 @default.
- W4366240178 cites W1981924512 @default.
- W4366240178 cites W1985266648 @default.
- W4366240178 cites W1996249363 @default.
- W4366240178 cites W2011211995 @default.
- W4366240178 cites W2014237487 @default.
- W4366240178 cites W2027221381 @default.
- W4366240178 cites W2031279614 @default.
- W4366240178 cites W2036787961 @default.
- W4366240178 cites W2047015778 @default.
- W4366240178 cites W2050388013 @default.
- W4366240178 cites W2052991849 @default.
- W4366240178 cites W2055254549 @default.
- W4366240178 cites W2059969460 @default.
- W4366240178 cites W2066180106 @default.
- W4366240178 cites W2078993601 @default.
- W4366240178 cites W2084665190 @default.
- W4366240178 cites W2087864381 @default.
- W4366240178 cites W2096964097 @default.
- W4366240178 cites W2098016509 @default.
- W4366240178 cites W2098874403 @default.
- W4366240178 cites W2101302162 @default.
- W4366240178 cites W2119957365 @default.
- W4366240178 cites W2147469412 @default.
- W4366240178 cites W2148202298 @default.
- W4366240178 cites W2148527632 @default.
- W4366240178 cites W2153217835 @default.
- W4366240178 cites W2154318907 @default.
- W4366240178 cites W2167512318 @default.
- W4366240178 cites W2167935306 @default.
- W4366240178 cites W2169836157 @default.
- W4366240178 cites W2264591140 @default.
- W4366240178 cites W2265782222 @default.
- W4366240178 cites W2746696507 @default.
- W4366240178 cites W2763718005 @default.
- W4366240178 cites W2787073674 @default.
- W4366240178 cites W2885014087 @default.
- W4366240178 cites W2891123677 @default.
- W4366240178 cites W3004626801 @default.
- W4366240178 cites W3013689262 @default.
- W4366240178 cites W3038353261 @default.
- W4366240178 cites W3038773011 @default.
- W4366240178 cites W3092216066 @default.
- W4366240178 cites W3108764799 @default.
- W4366240178 cites W3120605017 @default.
- W4366240178 cites W3121032204 @default.
- W4366240178 cites W3126137123 @default.
- W4366240178 cites W3130661172 @default.
- W4366240178 cites W3131782536 @default.
- W4366240178 cites W3141396499 @default.
- W4366240178 cites W3144275831 @default.
- W4366240178 cites W3164273203 @default.
- W4366240178 cites W3173478779 @default.
- W4366240178 cites W3173900383 @default.
- W4366240178 cites W3198440540 @default.
- W4366240178 cites W3199999033 @default.
- W4366240178 cites W4210297588 @default.
- W4366240178 cites W4220838245 @default.
- W4366240178 cites W4224215148 @default.
- W4366240178 cites W4281572722 @default.
- W4366240178 doi "https://doi.org/10.1172/jci.insight.164768" @default.
- W4366240178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37071470" @default.
- W4366240178 hasPublicationYear "2023" @default.
- W4366240178 type Work @default.
- W4366240178 citedByCount "0" @default.
- W4366240178 crossrefType "journal-article" @default.
- W4366240178 hasAuthorship W4366240178A5022184500 @default.
- W4366240178 hasAuthorship W4366240178A5024469424 @default.
- W4366240178 hasAuthorship W4366240178A5030189037 @default.
- W4366240178 hasAuthorship W4366240178A5077366004 @default.
- W4366240178 hasAuthorship W4366240178A5078552586 @default.
- W4366240178 hasAuthorship W4366240178A5087234088 @default.
- W4366240178 hasAuthorship W4366240178A5090043278 @default.
- W4366240178 hasBestOaLocation W43662401781 @default.
- W4366240178 hasConcept C118131993 @default.
- W4366240178 hasConcept C126322002 @default.
- W4366240178 hasConcept C134018914 @default.
- W4366240178 hasConcept C181709278 @default.
- W4366240178 hasConcept C207200792 @default.
- W4366240178 hasConcept C2776914184 @default.
- W4366240178 hasConcept C2778750056 @default.
- W4366240178 hasConcept C2778943923 @default.
- W4366240178 hasConcept C2779030066 @default.
- W4366240178 hasConcept C2779764123 @default.
- W4366240178 hasConcept C2779959927 @default.
- W4366240178 hasConcept C2780394045 @default.