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• W4366243075 abstract "Communication between the nervous and immune system is crucial for development, homeostasis and response to injury. Before the onset of neurogenesis, microglia populate the central nervous system, serving as resident immune cells over the course of life. Here, we describe new roles of an uncharacterized transcript upregulated by neurogenic progenitors during mouse corticogenesis: 4931414P19Rik (hereafter named P19). Overexpression of P19 cell-extrinsically inhibited neuronal migration and acted as chemoattractant of microglial cells. Interestingly, effects on neuronal migration were found to result directly from P19 secretion by neural progenitors triggering microglia accumulation within the P19 targeted area. Our findings highlight the crucial role of microglia during brain development and identify P19 as a previously unreported player in the neuro-immune crosstalk." @default.
• W4366243075 created "2023-04-20" @default.
• W4366243075 creator A5002249161 @default.
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• W4366243075 date "2023-04-28" @default.
• W4366243075 modified "2023-09-30" @default.
• W4366243075 title "4931414P19Rik, a microglia chemoattractant secreted by neural progenitors, modulates neuronal migration during corticogenesis" @default.
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• W4366243075 doi "https://doi.org/10.1242/dev.201574" @default.
• W4366243075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37070770" @default.
• W4366243075 hasPublicationYear "2023" @default.
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