FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366246039> ?p ?o ?g. }

• W4366246039 endingPage "9" @default.
• W4366246039 startingPage "1" @default.
• W4366246039 abstract "Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is important for saturated phosphatidylcholine (Sat-PC) production in the lung. Sat-PC is a critical component of pulmonary surfactant, which maintains low alveolar surface tension, facilitating respiration. Previous studies have reported an association between maternal and fetal LPCAT1 levels and neonatal lung function. Using a sheep model of pregnancy, we investigated a potential correlation between glucocorticoid-induced lung maturation and LPCAT1 mRNA and/or protein levels in the fetal lung, the placenta, the fetal plasma, and the maternal plasma.Eighty seven single pregnant ewes received maternal intramuscular injections of betamethasone. A sub-group of five animals had both maternal and fetal catheters installed to allow for sequential sampling from both plasma compartments. Lambs were surgically delivered under terminal anaesthesia between 2 and 8 days after initial ANS treatment, at a gestational age of 121-123 days. Lambs were ventilated for 30 min to determine functional lung maturation before being euthanized for necropsy and sample collection. Fetal lung, placenta, and fetal and maternal plasma samples were used to analyse LPCAT1 gene expression and protein levels.The expression of LPCAT1 mRNA in the fetal lung was significantly corelated to Sat-PC levels at 8 days (R2 = 0.23, p < 0.001) and lung maturation status overall (gas exchange efficiency as determined by measurements of lamb PaCO2 during ventilation, R2 = 0.20, p < 0.001). Similarly, fetal lung LPCAT1 mRNA was also significantly correlated with the individual durability of ANS effects on fetal lung maturation (R2 = 0.20, p < 0.001). Although ANS therapy altered LPCAT1 mRNA expression in the placenta, observed changes were independent of fetal lung maturation outcomes. Neither maternal nor fetal plasma LPCAT1 levels were changed by ANS therapy over the period, including in analysis of serial maternal and fetal samples from chronically catheterised animals.LPCAT1 expression in the fetal lung was associated with the durability of glucocorticoid effects on fetal lung maturation. However, LPCAT1 expression in the placenta, the fetal plasma, and the maternal plasma was neither associated with, nor predictive of fetal lung maturation after glucocorticoid treatment in a sheep model of pregnancy." @default.
• W4366246039 created "2023-04-20" @default.
• W4366246039 creator A5007865918 @default.
• W4366246039 creator A5016816941 @default.
• W4366246039 creator A5034406682 @default.
• W4366246039 creator A5036645819 @default.
• W4366246039 creator A5048997124 @default.
• W4366246039 creator A5053809198 @default.
• W4366246039 creator A5058229455 @default.
• W4366246039 creator A5069942321 @default.
• W4366246039 creator A5072899330 @default.
• W4366246039 creator A5074066396 @default.
• W4366246039 creator A5075249092 @default.
• W4366246039 creator A5089176517 @default.
• W4366246039 date "2023-07-01" @default.
• W4366246039 modified "2023-09-27" @default.
• W4366246039 title "LPCAT1 levels in the placenta, the maternal plasma and the fetal plasma do not predict fetal lung responses to glucocorticoids in a sheep model of pregnancy" @default.
• W4366246039 cites W1538386443 @default.
• W4366246039 cites W1857797615 @default.
• W4366246039 cites W1902039366 @default.
• W4366246039 cites W1967968986 @default.
• W4366246039 cites W1973025253 @default.
• W4366246039 cites W1977911448 @default.
• W4366246039 cites W1982268890 @default.
• W4366246039 cites W2008050730 @default.
• W4366246039 cites W2020552116 @default.
• W4366246039 cites W2023518167 @default.
• W4366246039 cites W2029958712 @default.
• W4366246039 cites W2040348102 @default.
• W4366246039 cites W2054526538 @default.
• W4366246039 cites W2059125534 @default.
• W4366246039 cites W2081989923 @default.
• W4366246039 cites W2086004537 @default.
• W4366246039 cites W2088066293 @default.
• W4366246039 cites W2109016292 @default.
• W4366246039 cites W2115910689 @default.
• W4366246039 cites W2116308534 @default.
• W4366246039 cites W2118790900 @default.
• W4366246039 cites W2129127301 @default.
• W4366246039 cites W2321364247 @default.
• W4366246039 cites W2344528832 @default.
• W4366246039 cites W2623661031 @default.
• W4366246039 cites W2754019839 @default.
• W4366246039 cites W2899384460 @default.
• W4366246039 cites W3027683983 @default.
• W4366246039 cites W3130678433 @default.
• W4366246039 cites W3202347426 @default.
• W4366246039 cites W4295046182 @default.
• W4366246039 doi "https://doi.org/10.1016/j.placenta.2023.04.012" @default.
• W4366246039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37146534" @default.
• W4366246039 hasPublicationYear "2023" @default.
• W4366246039 type Work @default.
• W4366246039 citedByCount "0" @default.
• W4366246039 crossrefType "journal-article" @default.
• W4366246039 hasAuthorship W4366246039A5007865918 @default.
• W4366246039 hasAuthorship W4366246039A5016816941 @default.
• W4366246039 hasAuthorship W4366246039A5034406682 @default.
• W4366246039 hasAuthorship W4366246039A5036645819 @default.
• W4366246039 hasAuthorship W4366246039A5048997124 @default.
• W4366246039 hasAuthorship W4366246039A5053809198 @default.
• W4366246039 hasAuthorship W4366246039A5058229455 @default.
• W4366246039 hasAuthorship W4366246039A5069942321 @default.
• W4366246039 hasAuthorship W4366246039A5072899330 @default.
• W4366246039 hasAuthorship W4366246039A5074066396 @default.
• W4366246039 hasAuthorship W4366246039A5075249092 @default.
• W4366246039 hasAuthorship W4366246039A5089176517 @default.
• W4366246039 hasConcept C126322002 @default.
• W4366246039 hasConcept C134018914 @default.
• W4366246039 hasConcept C16685009 @default.
• W4366246039 hasConcept C172680121 @default.
• W4366246039 hasConcept C2776953305 @default.
• W4366246039 hasConcept C2777714996 @default.
• W4366246039 hasConcept C2779234561 @default.
• W4366246039 hasConcept C2781162121 @default.
• W4366246039 hasConcept C46973012 @default.
• W4366246039 hasConcept C54355233 @default.
• W4366246039 hasConcept C71924100 @default.
• W4366246039 hasConcept C86803240 @default.
• W4366246039 hasConceptScore W4366246039C126322002 @default.
• W4366246039 hasConceptScore W4366246039C134018914 @default.
• W4366246039 hasConceptScore W4366246039C16685009 @default.
• W4366246039 hasConceptScore W4366246039C172680121 @default.
• W4366246039 hasConceptScore W4366246039C2776953305 @default.
• W4366246039 hasConceptScore W4366246039C2777714996 @default.
• W4366246039 hasConceptScore W4366246039C2779234561 @default.
• W4366246039 hasConceptScore W4366246039C2781162121 @default.
• W4366246039 hasConceptScore W4366246039C46973012 @default.
• W4366246039 hasConceptScore W4366246039C54355233 @default.
• W4366246039 hasConceptScore W4366246039C71924100 @default.
• W4366246039 hasConceptScore W4366246039C86803240 @default.
• W4366246039 hasFunder F4320309575 @default.
• W4366246039 hasFunder F4320313326 @default.
• W4366246039 hasFunder F4320320479 @default.
• W4366246039 hasFunder F4320330802 @default.
• W4366246039 hasLocation W43662460391 @default.
• W4366246039 hasLocation W43662460392 @default.
• W4366246039 hasOpenAccess W4366246039 @default.
• W4366246039 hasPrimaryLocation W43662460391 @default.

• next