FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366246377> ?p ?o ?g. }

• W4366246377 endingPage "152389" @default.
• W4366246377 startingPage "152389" @default.
• W4366246377 abstract "Despite the clinical success of PD-1/PD-1-ligand immunotherapy in non-small cell lung cancer (NSCLC), the appearance of primary and acquired therapy resistance is a major challenge reflecting that the mechanisms regulating the expression of the PD-1-ligands PD-L1 and PD-L2 are not fully explored. Type I and II interferons (IFNs) induce PD-L1 and PD-L2 expression. Here, we examined if PD-L1 and PD-L2 expression also can be induced by type III IFN, IFN-λ, which is peculiarly important for airway epithelial surfaces. In silico mRNA expression analysis of PD-L1 (CD274), PD-L2 (PDCD1LG2), and IFN- λ signaling signature genes in NSCLC tumors and cell lines was performed using RNA sequencing expression data from TCGA, OncoSG, and DepMap portals. IFN-λ-mediated induction of PD-L1 and PD-L2 expression in NSCLC cell lines was examined by real-time quantitative polymerase chain reaction and flow cytometry. IFNL genes encoding IFN- λ variants are expressed in the majority of NSCLC tumors and cell lines along with the IFNLR1 and IL10R2 genes encoding the IFN-λ receptor subunits. The expression of PD-L1 and PD-L2 mRNA is higher in NSCLC tumors with IFNL mRNA expression compared to tumors without IFNL expression. In the NSCLC cell line HCC827, stimulation with IFN-λ induced both an increase in PD-L1 and PD-L2 mRNA expression and cell surface abundance of the corresponding proteins. In the NSCLC cell line A427, displaying a low basal expression of PD-L1 and PD-L2 mRNA and corresponding proteins, stimulation with IFN-λ resulted in an induction of the former. The type III IFN, IFN- λ, is capable of inducing PD-L1 and PD-L2 expression, at least in some NSCLC cells, and this regulation will need acknowledgment in the development of new diagnostic procedures, such as gene expression signature profiles, to improve PD-1/PD-1-ligand immunotherapy in NSCLC." @default.
• W4366246377 created "2023-04-20" @default.
• W4366246377 creator A5004856453 @default.
• W4366246377 creator A5014585030 @default.
• W4366246377 creator A5018289495 @default.
• W4366246377 creator A5069515486 @default.
• W4366246377 creator A5082107654 @default.
• W4366246377 date "2023-05-01" @default.
• W4366246377 modified "2023-10-14" @default.
• W4366246377 title "PD-L1 and PD-L2 immune checkpoint protein induction by type III interferon in non-small cell lung cancer cells" @default.
• W4366246377 cites W1544174173 @default.
• W4366246377 cites W1547599695 @default.
• W4366246377 cites W1752668680 @default.
• W4366246377 cites W1975923823 @default.
• W4366246377 cites W1982488143 @default.
• W4366246377 cites W1987009823 @default.
• W4366246377 cites W1996432689 @default.
• W4366246377 cites W2013202475 @default.
• W4366246377 cites W2017896938 @default.
• W4366246377 cites W2023942263 @default.
• W4366246377 cites W2032064870 @default.
• W4366246377 cites W2040793402 @default.
• W4366246377 cites W2063264144 @default.
• W4366246377 cites W2068931925 @default.
• W4366246377 cites W2075413744 @default.
• W4366246377 cites W2078844752 @default.
• W4366246377 cites W2083162205 @default.
• W4366246377 cites W2086409213 @default.
• W4366246377 cites W2100396313 @default.
• W4366246377 cites W2103100668 @default.
• W4366246377 cites W2104347254 @default.
• W4366246377 cites W2114843025 @default.
• W4366246377 cites W2121451364 @default.
• W4366246377 cites W2131577873 @default.
• W4366246377 cites W2149441684 @default.
• W4366246377 cites W2154234066 @default.
• W4366246377 cites W2157135427 @default.
• W4366246377 cites W2293531514 @default.
• W4366246377 cites W2527905628 @default.
• W4366246377 cites W2552750859 @default.
• W4366246377 cites W2608165987 @default.
• W4366246377 cites W2655262992 @default.
• W4366246377 cites W2745732448 @default.
• W4366246377 cites W2749553776 @default.
• W4366246377 cites W2752561188 @default.
• W4366246377 cites W2768804444 @default.
• W4366246377 cites W2782007611 @default.
• W4366246377 cites W2792801933 @default.
• W4366246377 cites W2792850129 @default.
• W4366246377 cites W2793835936 @default.
• W4366246377 cites W2794621764 @default.
• W4366246377 cites W2797182287 @default.
• W4366246377 cites W2884237051 @default.
• W4366246377 cites W2901668149 @default.
• W4366246377 cites W2948046941 @default.
• W4366246377 cites W2948374725 @default.
• W4366246377 cites W2999372945 @default.
• W4366246377 cites W3004318979 @default.
• W4366246377 cites W3014320042 @default.
• W4366246377 cites W3017272456 @default.
• W4366246377 cites W3030603206 @default.
• W4366246377 cites W3034398616 @default.
• W4366246377 cites W3080330000 @default.
• W4366246377 cites W3099496572 @default.
• W4366246377 cites W3215593967 @default.
• W4366246377 cites W4253483740 @default.
• W4366246377 cites W4353066330 @default.
• W4366246377 doi "https://doi.org/10.1016/j.imbio.2023.152389" @default.
• W4366246377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37146414" @default.
• W4366246377 hasPublicationYear "2023" @default.
• W4366246377 type Work @default.
• W4366246377 citedByCount "2" @default.
• W4366246377 countsByYear W43662463772023 @default.
• W4366246377 crossrefType "journal-article" @default.
• W4366246377 hasAuthorship W4366246377A5004856453 @default.
• W4366246377 hasAuthorship W4366246377A5014585030 @default.
• W4366246377 hasAuthorship W4366246377A5018289495 @default.
• W4366246377 hasAuthorship W4366246377A5069515486 @default.
• W4366246377 hasAuthorship W4366246377A5082107654 @default.
• W4366246377 hasBestOaLocation W43662463771 @default.
• W4366246377 hasConcept C104317684 @default.
• W4366246377 hasConcept C105580179 @default.
• W4366246377 hasConcept C143998085 @default.
• W4366246377 hasConcept C1491633281 @default.
• W4366246377 hasConcept C150194340 @default.
• W4366246377 hasConcept C153911025 @default.
• W4366246377 hasConcept C203014093 @default.
• W4366246377 hasConcept C2776090121 @default.
• W4366246377 hasConcept C2776178377 @default.
• W4366246377 hasConcept C2776256026 @default.
• W4366246377 hasConcept C2777701055 @default.
• W4366246377 hasConcept C2778326572 @default.
• W4366246377 hasConcept C2781053074 @default.
• W4366246377 hasConcept C502942594 @default.
• W4366246377 hasConcept C54355233 @default.
• W4366246377 hasConcept C553184892 @default.
• W4366246377 hasConcept C55493867 @default.
• W4366246377 hasConcept C71924100 @default.

• next