Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366247952> ?p ?o ?g. }
- W4366247952 abstract "Neuronally orchestrated muscular movement and locomotion are defining faculties of multicellular animals. Due to its simple brain and genetic accessibility, the larva of the fruit fly Drosophila melanogaster allows one to study these processes at tractable levels of complexity. However, although the faculty of locomotion clearly pertains to the individual, most studies of locomotion in larvae use measurements aggregated across animals, or animals tested one by one, an extravagance for larger-scale analyses. This prevents grasping the inter- and intra-individual variability in locomotion and its neurogenetic determinants. Here, we present the IMBA (individual maggot behaviour analyser) for analysing the behaviour of individual larvae within groups, reliably resolving individual identity across collisions. We use the IMBA to systematically describe the inter- and intra-individual variability in locomotion of wild-type animals, and how the variability is reduced by associative learning. We then report a novel locomotion phenotype of an adhesion GPCR mutant. We further investigated the modulation of locomotion across repeated activations of dopamine neurons in individual animals, and the transient backward locomotion induced by brief optogenetic activation of the brain-descending 'mooncrawler' neurons. In summary, the IMBA is an easy-to-use toolbox allowing an unprecedentedly rich view of the behaviour and its variability of individual larvae, with utility in multiple biomedical research contexts." @default.
- W4366247952 created "2023-04-20" @default.
- W4366247952 creator A5009268350 @default.
- W4366247952 creator A5015030892 @default.
- W4366247952 creator A5017415848 @default.
- W4366247952 creator A5055750487 @default.
- W4366247952 creator A5058204291 @default.
- W4366247952 creator A5059567975 @default.
- W4366247952 creator A5063759581 @default.
- W4366247952 creator A5072002450 @default.
- W4366247952 creator A5073921986 @default.
- W4366247952 creator A5080494091 @default.
- W4366247952 date "2023-04-01" @default.
- W4366247952 modified "2023-10-14" @default.
- W4366247952 title "High-resolution analysis of individual <i>Drosophila melanogaster</i> larvae uncovers individual variability in locomotion and its neurogenetic modulation" @default.
- W4366247952 cites W1691107957 @default.
- W4366247952 cites W1925492557 @default.
- W4366247952 cites W1951518548 @default.
- W4366247952 cites W1971074619 @default.
- W4366247952 cites W1973680324 @default.
- W4366247952 cites W1974260937 @default.
- W4366247952 cites W1978157456 @default.
- W4366247952 cites W1981024652 @default.
- W4366247952 cites W1997078804 @default.
- W4366247952 cites W1997883797 @default.
- W4366247952 cites W2001457444 @default.
- W4366247952 cites W2009452670 @default.
- W4366247952 cites W2021777472 @default.
- W4366247952 cites W2029648185 @default.
- W4366247952 cites W2035694260 @default.
- W4366247952 cites W2040631236 @default.
- W4366247952 cites W2051852715 @default.
- W4366247952 cites W2059222243 @default.
- W4366247952 cites W2061260648 @default.
- W4366247952 cites W2068113013 @default.
- W4366247952 cites W2073210804 @default.
- W4366247952 cites W2075468715 @default.
- W4366247952 cites W2077521370 @default.
- W4366247952 cites W2086361749 @default.
- W4366247952 cites W2086653658 @default.
- W4366247952 cites W2091835225 @default.
- W4366247952 cites W2107901821 @default.
- W4366247952 cites W2112474181 @default.
- W4366247952 cites W2117672081 @default.
- W4366247952 cites W2132663430 @default.
- W4366247952 cites W2133059825 @default.
- W4366247952 cites W2137760010 @default.
- W4366247952 cites W2143076704 @default.
- W4366247952 cites W2146835230 @default.
- W4366247952 cites W2158437489 @default.
- W4366247952 cites W2166999914 @default.
- W4366247952 cites W2181199607 @default.
- W4366247952 cites W2253563636 @default.
- W4366247952 cites W2261263381 @default.
- W4366247952 cites W2288653959 @default.
- W4366247952 cites W2313798176 @default.
- W4366247952 cites W2398456342 @default.
- W4366247952 cites W2404584278 @default.
- W4366247952 cites W2414776622 @default.
- W4366247952 cites W2472629575 @default.
- W4366247952 cites W2489134213 @default.
- W4366247952 cites W2531045959 @default.
- W4366247952 cites W2537588712 @default.
- W4366247952 cites W2587890802 @default.
- W4366247952 cites W2605236636 @default.
- W4366247952 cites W2606760007 @default.
- W4366247952 cites W2606986849 @default.
- W4366247952 cites W2613328654 @default.
- W4366247952 cites W2617763707 @default.
- W4366247952 cites W2619970632 @default.
- W4366247952 cites W2728178741 @default.
- W4366247952 cites W2732575184 @default.
- W4366247952 cites W2742439855 @default.
- W4366247952 cites W2775091018 @default.
- W4366247952 cites W2793333536 @default.
- W4366247952 cites W2800560189 @default.
- W4366247952 cites W2885496356 @default.
- W4366247952 cites W2886372032 @default.
- W4366247952 cites W2901208536 @default.
- W4366247952 cites W2901489210 @default.
- W4366247952 cites W2911964244 @default.
- W4366247952 cites W2920308385 @default.
- W4366247952 cites W2942930317 @default.
- W4366247952 cites W2953259704 @default.
- W4366247952 cites W2969835374 @default.
- W4366247952 cites W2972100596 @default.
- W4366247952 cites W2981550286 @default.
- W4366247952 cites W2996545132 @default.
- W4366247952 cites W3007366222 @default.
- W4366247952 cites W3009773645 @default.
- W4366247952 cites W3012591046 @default.
- W4366247952 cites W3037636358 @default.
- W4366247952 cites W3043319222 @default.
- W4366247952 cites W3088731613 @default.
- W4366247952 cites W3097287971 @default.
- W4366247952 cites W3131145322 @default.
- W4366247952 cites W3161181060 @default.
- W4366247952 cites W3181455983 @default.
- W4366247952 cites W3183622323 @default.
- W4366247952 cites W3188628968 @default.