Matches in SemOpenAlex for { <https://semopenalex.org/work/W43662486> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W43662486 endingPage "15" @default.
- W43662486 startingPage "108" @default.
- W43662486 abstract "Eicosanoids, in particular prostaglandin E2 (PGE2), are potent inhibitors of a number of immune responses, including lymphocyte proliferation. We have previously shown that fatty acids, especially polyunsaturated fatty acids (PUFA), inhibit mitogen-stimulated proliferation of lymphocytes. One mechanism by which fatty acids could exert their inhibitory effect is via modulation of eicosanoid synthesis. This possibility was investigated in the present study. PGE2 concentrations in the medium taken from lymphocytes cultured in the presence of a range of different fatty acids did not correlate with the inhibitory effects of the fatty acids upon lymphocyte proliferation. Although PGE2 at concentrations above 10 nM caused inhibition of lymphocyte proliferation, PGE2 at the concentration measured in lymphocyte culture medium (0.3-4 nM) was not inhibitory. PGE3 did not inhibit lymphocyte proliferation, except at high concentrations (greater than 250 nM). The maximal inhibition of proliferation caused by PGE2 or PGE3 was less than the inhibition caused by each of the fatty acids except myristic or palmitic acids. Inclusion of inhibitors of phospholipase A2, cyclo-oxygenase or lipoxygenase in the culture medium did not prevent the fatty acids from exerting their inhibitory effect on lymphocyte proliferation. The eicosanoids present in lymph node cell cultures originate from macrophages rather than lymphocytes. Depletion of macrophages from the cell preparation by adherence did not prevent fatty acids from inhibiting proliferation. Proliferation of thoracic duct lymphocytes, which are devoid of macrophages, is inhibited by fatty acids to a similar extent as proliferation of lymph node lymphocytes. These observations provide convincing evidence that the inhibition of lymphocyte proliferation by fatty acids is independent of the production of eicosanoids. Therefore, other mechanisms must be investigated if the effect of fatty acids upon lymphocyte proliferation is to be understood at a biochemical level." @default.
- W43662486 created "2016-06-24" @default.
- W43662486 creator A5037364494 @default.
- W43662486 creator A5052054400 @default.
- W43662486 creator A5069550530 @default.
- W43662486 date "1992-01-01" @default.
- W43662486 modified "2023-10-16" @default.
- W43662486 title "The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism." @default.
- W43662486 cites W1411490118 @default.
- W43662486 cites W1506916331 @default.
- W43662486 cites W1546214748 @default.
- W43662486 cites W1563827978 @default.
- W43662486 cites W1590040857 @default.
- W43662486 cites W1595306598 @default.
- W43662486 cites W186629198 @default.
- W43662486 cites W1911021899 @default.
- W43662486 cites W1971661892 @default.
- W43662486 cites W1989825919 @default.
- W43662486 cites W1990487867 @default.
- W43662486 cites W1991260449 @default.
- W43662486 cites W1993743334 @default.
- W43662486 cites W1995854222 @default.
- W43662486 cites W2059595776 @default.
- W43662486 cites W208010477 @default.
- W43662486 cites W2087650137 @default.
- W43662486 cites W2106928217 @default.
- W43662486 cites W2119835942 @default.
- W43662486 cites W2151129289 @default.
- W43662486 cites W2151379250 @default.
- W43662486 cites W2152472326 @default.
- W43662486 cites W2166987756 @default.
- W43662486 cites W2307813201 @default.
- W43662486 cites W2410595353 @default.
- W43662486 cites W2417238432 @default.
- W43662486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1384811" @default.
- W43662486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1537586" @default.
- W43662486 hasPublicationYear "1992" @default.
- W43662486 type Work @default.
- W43662486 sameAs 43662486 @default.
- W43662486 citedByCount "48" @default.
- W43662486 countsByYear W436624862012 @default.
- W43662486 countsByYear W436624862013 @default.
- W43662486 countsByYear W436624862016 @default.
- W43662486 countsByYear W436624862017 @default.
- W43662486 countsByYear W436624862018 @default.
- W43662486 countsByYear W436624862022 @default.
- W43662486 countsByYear W436624862023 @default.
- W43662486 crossrefType "journal-article" @default.
- W43662486 hasAuthorship W43662486A5037364494 @default.
- W43662486 hasAuthorship W43662486A5052054400 @default.
- W43662486 hasAuthorship W43662486A5069550530 @default.
- W43662486 hasConcept C181199279 @default.
- W43662486 hasConcept C19038510 @default.
- W43662486 hasConcept C203014093 @default.
- W43662486 hasConcept C2776352991 @default.
- W43662486 hasConcept C2776551241 @default.
- W43662486 hasConcept C2777198256 @default.
- W43662486 hasConcept C2777761686 @default.
- W43662486 hasConcept C2778078955 @default.
- W43662486 hasConcept C2780664492 @default.
- W43662486 hasConcept C2780857362 @default.
- W43662486 hasConcept C543025807 @default.
- W43662486 hasConcept C55493867 @default.
- W43662486 hasConcept C62112901 @default.
- W43662486 hasConcept C86803240 @default.
- W43662486 hasConceptScore W43662486C181199279 @default.
- W43662486 hasConceptScore W43662486C19038510 @default.
- W43662486 hasConceptScore W43662486C203014093 @default.
- W43662486 hasConceptScore W43662486C2776352991 @default.
- W43662486 hasConceptScore W43662486C2776551241 @default.
- W43662486 hasConceptScore W43662486C2777198256 @default.
- W43662486 hasConceptScore W43662486C2777761686 @default.
- W43662486 hasConceptScore W43662486C2778078955 @default.
- W43662486 hasConceptScore W43662486C2780664492 @default.
- W43662486 hasConceptScore W43662486C2780857362 @default.
- W43662486 hasConceptScore W43662486C543025807 @default.
- W43662486 hasConceptScore W43662486C55493867 @default.
- W43662486 hasConceptScore W43662486C62112901 @default.
- W43662486 hasConceptScore W43662486C86803240 @default.
- W43662486 hasIssue "1" @default.
- W43662486 hasLocation W436624861 @default.
- W43662486 hasOpenAccess W43662486 @default.
- W43662486 hasPrimaryLocation W436624861 @default.
- W43662486 hasRelatedWork W131142795 @default.
- W43662486 hasRelatedWork W165895597 @default.
- W43662486 hasRelatedWork W1965548460 @default.
- W43662486 hasRelatedWork W2060195701 @default.
- W43662486 hasRelatedWork W2086410927 @default.
- W43662486 hasRelatedWork W2097771772 @default.
- W43662486 hasRelatedWork W2124445187 @default.
- W43662486 hasRelatedWork W2171416397 @default.
- W43662486 hasRelatedWork W227397471 @default.
- W43662486 hasRelatedWork W2416415888 @default.
- W43662486 hasVolume "75" @default.
- W43662486 isParatext "false" @default.
- W43662486 isRetracted "false" @default.
- W43662486 magId "43662486" @default.
- W43662486 workType "article" @default.