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- W4366260013 endingPage "5684" @default.
- W4366260013 startingPage "5669" @default.
- W4366260013 abstract "To develop the next-generation Pt drug with remarkable activity and low toxicity to maximally inhibit tumor growth, we optimized a Pt(II) thiosemicarbazone compound (C4) with remarkable cytotoxicity to SK-N-MC cells and then constructed a new human serum albumin-C4 (HSA-C4) complex delivery system. The in vivo results showed that C4 and the HSA-C4 complex have remarkable therapeutic efficiency and almost no toxicity; they induced apoptosis and inhibited tumor angiogenesis. This system showed potential as a practical Pt drug. This study could pave the way for developing next-generation dual-targeted Pt drugs and achieving their targeting therapy for cancer." @default.
- W4366260013 created "2023-04-20" @default.
- W4366260013 creator A5001016477 @default.
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- W4366260013 creator A5071176922 @default.
- W4366260013 creator A5071243504 @default.
- W4366260013 creator A5078936303 @default.
- W4366260013 date "2023-04-18" @default.
- W4366260013 modified "2023-10-17" @default.
- W4366260013 title "Developing an Anticancer Platinum(II) Compound Based on the Uniqueness of Human Serum Albumin" @default.
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