Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366273357> ?p ?o ?g. }
- W4366273357 endingPage "113777" @default.
- W4366273357 startingPage "113777" @default.
- W4366273357 abstract "P: radix is a perennial herb, and its extracts have various biological properties that make it a potential candidate for the treatment of tumors, edema, and lymphatic stasis. However, the main factor contributing to its toxicity are not clear. Here, we used a zebrafish toxicological model to study the main toxicity factor of P. radix and explore the potential mechanisms involved. The results revealed that Esculentoside B was the major toxic factor of P. radix. Exposure of zebrafish larvae to Esculentoside B caused developmental abnormalities, neurotoxicity and altered locomotor behavior. The combination of AChE activity and the expression levels of genes relevant to CNS development demonstrated that Esculentoside B is neurotoxic to zebrafish larvae, impairs their CNS development, and that AChE may be a toxic target of Esculentoside B. Metabolomic analysis has revealed that Esculentoside B exposure can disrupt D-Amino acid metabolism, protein export, autophagy, and mTOR signaling pathways in zebrafish larvae. These findings provide insights into the molecular mechanisms underlying EsB-induced neurotoxicity in zebrafish, which can facilitate further research and development of P. radix for safe consumption." @default.
- W4366273357 created "2023-04-20" @default.
- W4366273357 creator A5010842883 @default.
- W4366273357 creator A5018395784 @default.
- W4366273357 creator A5028856871 @default.
- W4366273357 creator A5044852325 @default.
- W4366273357 creator A5061666008 @default.
- W4366273357 creator A5065425238 @default.
- W4366273357 creator A5068325671 @default.
- W4366273357 date "2023-06-01" @default.
- W4366273357 modified "2023-10-18" @default.
- W4366273357 title "Metabolic exploration of the developmental abnormalities and neurotoxicity of Esculentoside B, the main toxic factor in Phytolaccae radix" @default.
- W4366273357 cites W1536770861 @default.
- W4366273357 cites W1543068333 @default.
- W4366273357 cites W1615535881 @default.
- W4366273357 cites W1971173167 @default.
- W4366273357 cites W1977163370 @default.
- W4366273357 cites W1978811170 @default.
- W4366273357 cites W1979742015 @default.
- W4366273357 cites W1981239255 @default.
- W4366273357 cites W1983940209 @default.
- W4366273357 cites W2009973632 @default.
- W4366273357 cites W2037753888 @default.
- W4366273357 cites W2068638855 @default.
- W4366273357 cites W2080984829 @default.
- W4366273357 cites W2085185786 @default.
- W4366273357 cites W2101113365 @default.
- W4366273357 cites W2109645417 @default.
- W4366273357 cites W2111444310 @default.
- W4366273357 cites W2135710940 @default.
- W4366273357 cites W2138586407 @default.
- W4366273357 cites W2148989249 @default.
- W4366273357 cites W2168301488 @default.
- W4366273357 cites W2187903924 @default.
- W4366273357 cites W2325648398 @default.
- W4366273357 cites W2346677630 @default.
- W4366273357 cites W2507588877 @default.
- W4366273357 cites W2553119477 @default.
- W4366273357 cites W2742646427 @default.
- W4366273357 cites W2752409045 @default.
- W4366273357 cites W2758320018 @default.
- W4366273357 cites W2760631915 @default.
- W4366273357 cites W2762435278 @default.
- W4366273357 cites W2789319500 @default.
- W4366273357 cites W2793637392 @default.
- W4366273357 cites W2807959602 @default.
- W4366273357 cites W2885538937 @default.
- W4366273357 cites W2904693503 @default.
- W4366273357 cites W2911204448 @default.
- W4366273357 cites W2937662637 @default.
- W4366273357 cites W2971804265 @default.
- W4366273357 cites W2971880881 @default.
- W4366273357 cites W2976715062 @default.
- W4366273357 cites W2980503164 @default.
- W4366273357 cites W2986398204 @default.
- W4366273357 cites W2997491262 @default.
- W4366273357 cites W3014860409 @default.
- W4366273357 cites W3016124517 @default.
- W4366273357 cites W3019913929 @default.
- W4366273357 cites W3037257180 @default.
- W4366273357 cites W3040732672 @default.
- W4366273357 cites W3087995600 @default.
- W4366273357 cites W3094898874 @default.
- W4366273357 cites W3096915326 @default.
- W4366273357 cites W3099937361 @default.
- W4366273357 cites W3120566400 @default.
- W4366273357 cites W3133229261 @default.
- W4366273357 cites W3149885324 @default.
- W4366273357 cites W3180347673 @default.
- W4366273357 cites W3194841450 @default.
- W4366273357 cites W3201464819 @default.
- W4366273357 cites W3202292984 @default.
- W4366273357 cites W3205881985 @default.
- W4366273357 cites W3209062257 @default.
- W4366273357 cites W3209071718 @default.
- W4366273357 cites W3209545512 @default.
- W4366273357 cites W3216994527 @default.
- W4366273357 cites W4206447491 @default.
- W4366273357 cites W4220654741 @default.
- W4366273357 cites W4223653664 @default.
- W4366273357 cites W4225117087 @default.
- W4366273357 cites W4229058991 @default.
- W4366273357 cites W4294845636 @default.
- W4366273357 cites W4307161868 @default.
- W4366273357 doi "https://doi.org/10.1016/j.fct.2023.113777" @default.
- W4366273357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37080526" @default.
- W4366273357 hasPublicationYear "2023" @default.
- W4366273357 type Work @default.
- W4366273357 citedByCount "1" @default.
- W4366273357 crossrefType "journal-article" @default.
- W4366273357 hasAuthorship W4366273357A5010842883 @default.
- W4366273357 hasAuthorship W4366273357A5018395784 @default.
- W4366273357 hasAuthorship W4366273357A5028856871 @default.
- W4366273357 hasAuthorship W4366273357A5044852325 @default.
- W4366273357 hasAuthorship W4366273357A5061666008 @default.
- W4366273357 hasAuthorship W4366273357A5065425238 @default.
- W4366273357 hasAuthorship W4366273357A5068325671 @default.
- W4366273357 hasConcept C104317684 @default.