Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366277558> ?p ?o ?g. }
- W4366277558 endingPage "686" @default.
- W4366277558 startingPage "686" @default.
- W4366277558 abstract "Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest. Senescent cells are characterized by their senescence-associated secretory phenotype that overproduces inflammatory and catabolic factors that hamper normal tissue homeostasis. Chronic accumulation of senescent cells is thought to be associated with intervertebral disc degeneration (IDD) in an aging population. This IDD is one of the largest age-dependent chronic disorders, often associated with neurological dysfunctions such as, low back pain, radiculopathy, and myelopathy. Senescent cells (SnCs) increase in number in the aged, degenerated discs, and have a causative role in driving age-related IDD. This review summarizes current evidence supporting the role of CS on onset and progression of age-related IDD. The discussion includes molecular pathways involved in CS such as p53-p21CIP1, p16INK4a, NF-κB, and MAPK, and the potential therapeutic value of targeting these pathways. We propose several mechanisms of CS in IDD including mechanical stress, oxidative stress, genotoxic stress, nutritional deprivation, and inflammatory stress. There are still large knowledge gaps in disc CS research, an understanding of which will provide opportunities to develop therapeutic interventions to treat age-related IDD." @default.
- W4366277558 created "2023-04-20" @default.
- W4366277558 creator A5024885498 @default.
- W4366277558 creator A5026929130 @default.
- W4366277558 creator A5031034301 @default.
- W4366277558 creator A5033101463 @default.
- W4366277558 creator A5040467127 @default.
- W4366277558 creator A5049327895 @default.
- W4366277558 creator A5080116611 @default.
- W4366277558 date "2023-04-18" @default.
- W4366277558 modified "2023-10-15" @default.
- W4366277558 title "Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities" @default.
- W4366277558 cites W1790117378 @default.
- W4366277558 cites W1823374409 @default.
- W4366277558 cites W1964059126 @default.
- W4366277558 cites W1971036564 @default.
- W4366277558 cites W1974047233 @default.
- W4366277558 cites W1975790148 @default.
- W4366277558 cites W1978992462 @default.
- W4366277558 cites W1994540097 @default.
- W4366277558 cites W1994867329 @default.
- W4366277558 cites W2027885447 @default.
- W4366277558 cites W2033289742 @default.
- W4366277558 cites W2043752417 @default.
- W4366277558 cites W2048376025 @default.
- W4366277558 cites W2065246790 @default.
- W4366277558 cites W2067682644 @default.
- W4366277558 cites W2069519394 @default.
- W4366277558 cites W2085012640 @default.
- W4366277558 cites W2087835012 @default.
- W4366277558 cites W2089401029 @default.
- W4366277558 cites W2095299803 @default.
- W4366277558 cites W2101410699 @default.
- W4366277558 cites W2105521212 @default.
- W4366277558 cites W2112458458 @default.
- W4366277558 cites W2128807350 @default.
- W4366277558 cites W2130458932 @default.
- W4366277558 cites W2140930678 @default.
- W4366277558 cites W2158969445 @default.
- W4366277558 cites W2162057862 @default.
- W4366277558 cites W2164879283 @default.
- W4366277558 cites W2310326609 @default.
- W4366277558 cites W2342684152 @default.
- W4366277558 cites W2346306153 @default.
- W4366277558 cites W2395207553 @default.
- W4366277558 cites W2415916782 @default.
- W4366277558 cites W2519035758 @default.
- W4366277558 cites W2534715239 @default.
- W4366277558 cites W2544998112 @default.
- W4366277558 cites W2545116789 @default.
- W4366277558 cites W2557122684 @default.
- W4366277558 cites W2576428133 @default.
- W4366277558 cites W2585432400 @default.
- W4366277558 cites W2588793253 @default.
- W4366277558 cites W2591114726 @default.
- W4366277558 cites W2600591883 @default.
- W4366277558 cites W2608191330 @default.
- W4366277558 cites W2608899726 @default.
- W4366277558 cites W2696350131 @default.
- W4366277558 cites W2739790966 @default.
- W4366277558 cites W2750509325 @default.
- W4366277558 cites W2751831991 @default.
- W4366277558 cites W2754286293 @default.
- W4366277558 cites W2757416034 @default.
- W4366277558 cites W2761032015 @default.
- W4366277558 cites W2772570065 @default.
- W4366277558 cites W2773643222 @default.
- W4366277558 cites W2779546462 @default.
- W4366277558 cites W2787823766 @default.
- W4366277558 cites W2790085571 @default.
- W4366277558 cites W2790888505 @default.
- W4366277558 cites W2791201946 @default.
- W4366277558 cites W2792444892 @default.
- W4366277558 cites W2793622197 @default.
- W4366277558 cites W2793958146 @default.
- W4366277558 cites W2795875233 @default.
- W4366277558 cites W2796202687 @default.
- W4366277558 cites W2803346805 @default.
- W4366277558 cites W2804373912 @default.
- W4366277558 cites W2809899663 @default.
- W4366277558 cites W2810204953 @default.
- W4366277558 cites W2811313118 @default.
- W4366277558 cites W2811447564 @default.
- W4366277558 cites W2890376302 @default.
- W4366277558 cites W2895518858 @default.
- W4366277558 cites W2895969593 @default.
- W4366277558 cites W2897612893 @default.
- W4366277558 cites W2897698831 @default.
- W4366277558 cites W2898423146 @default.
- W4366277558 cites W2899178822 @default.
- W4366277558 cites W2899967263 @default.
- W4366277558 cites W2901679280 @default.
- W4366277558 cites W2908664203 @default.
- W4366277558 cites W2914013234 @default.
- W4366277558 cites W2916615397 @default.
- W4366277558 cites W2917378099 @default.
- W4366277558 cites W2924714478 @default.
- W4366277558 cites W2934209063 @default.