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• W4366277582 abstract "Introduction Hereditary angioedema due to C1-inhibitor deficiency is influenced by hormonal factors, with a more severe course of disease in women. Our study aims to deepen the impact of puberty on onset, frequency, location and severity of attacks. Methods Retrospective data were collected through a semi-structured questionnaire and shared by 10 Italian reference centers of the Italian Network for Hereditary and Acquired Angioedema (ITACA). Results The proportion of symptomatic patients increased significantly after puberty (98.2% vs 83.9%, p =0.002 in males; 96.3% vs 68,4%, p &lt;0.001 in females); the monthly mean of acute attacks was significantly higher after puberty, and this occurred both in females (median (IQR) = 0.41(2) in the three years before puberty vs 2(2.17) in the three years after, p &lt;0.001) and in males (1(1.92) vs 1.25(1.56) respectively, p &lt;0.001). The increase was greater in females. No significant differences were detected in attack location before and after puberty. Discussion Overall, our study confirms previous reports on a more severe phenotype in the female gender. Puberty predisposes to increased numbers of angioedema attacks, in particular in female patients." @default.
• W4366277582 created "2023-04-20" @default.
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• W4366277582 date "2023-04-18" @default.
• W4366277582 modified "2023-10-14" @default.
• W4366277582 title "The impact of puberty on the onset, frequency, location, and severity of attacks in hereditary angioedema due to C1-inhibitor deficiency: A survey from the Italian Network for Hereditary and Acquired Angioedema (ITACA)" @default.
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• W4366277582 doi "https://doi.org/10.3389/fped.2023.1141073" @default.
• W4366277582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37144145" @default.
• W4366277582 hasPublicationYear "2023" @default.
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