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- W4366278987 abstract "A robust process technology for the manufacture of the active pharmaceutical ingredient (API) amodiaquine dihydrochloride dihydrate (ADQ, 3), an important antimalarial, is reported. The process consists of a three-step synthetic route that involves a Mannich reaction, condensation with 4,7-dichloroquinoline (DCQ, 5) and rehydration. Additionally, a cost-competitive process for the production of DCQ (5) is also reported wherein DCQ (5) was prepared in four steps from meta-chloroaniline (7). 4-Amido-2-(diethylaminomethyl)phenol (14), DCQ (5), and ADQ (3) were obtained in yields of 92, 89 and 90% respectively." @default.
- W4366278987 created "2023-04-20" @default.
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- W4366278987 date "2023-04-18" @default.
- W4366278987 modified "2023-09-25" @default.
- W4366278987 title "Process Development for the Manufacture of the Antimalarial Amodiaquine Dihydrochloride Dihydrate" @default.
- W4366278987 doi "https://doi.org/10.26434/chemrxiv-2023-5sw1f" @default.
- W4366278987 hasPublicationYear "2023" @default.
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