Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366281314> ?p ?o ?g. }
- W4366281314 abstract "Tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) are essential for pigmentation. They are generally classified as type-3 copper proteins, with binuclear copper active sites. Although there is experimental evidence for a copper cofactor in TYR, delivered via the copper transporter, ATP7A, the presence of copper in TYRP1 and TYRP2 has not been demonstrated. Here, we report that the expression and function of TYRP1 requires zinc, mediated by ZNT5-ZNT6 heterodimers (ZNT5-6) or ZNT7-ZNT7 homodimers (ZNT7). Loss of ZNT5-6 and ZNT7 function results in hypopigmentation in medaka fish and human melanoma cells, and is accompanied by immature melanosomes and reduced melanin content, as observed in TYRP1 dysfunction. The requirement of ZNT5-6 and ZNT7 for TYRP1 expression is conserved in human, mouse, and chicken orthologs. Our results provide novel insights into the pigmentation process and address questions regarding metalation in tyrosinase protein family." @default.
- W4366281314 created "2023-04-20" @default.
- W4366281314 creator A5006739692 @default.
- W4366281314 creator A5023576389 @default.
- W4366281314 creator A5024867640 @default.
- W4366281314 creator A5028588562 @default.
- W4366281314 creator A5029057531 @default.
- W4366281314 creator A5067447552 @default.
- W4366281314 creator A5074398856 @default.
- W4366281314 creator A5076876397 @default.
- W4366281314 creator A5080070548 @default.
- W4366281314 creator A5083163427 @default.
- W4366281314 date "2023-04-18" @default.
- W4366281314 modified "2023-10-14" @default.
- W4366281314 title "Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins" @default.
- W4366281314 cites W1498389773 @default.
- W4366281314 cites W1514187524 @default.
- W4366281314 cites W1514582998 @default.
- W4366281314 cites W1536967003 @default.
- W4366281314 cites W1561410732 @default.
- W4366281314 cites W1582410083 @default.
- W4366281314 cites W1867320313 @default.
- W4366281314 cites W1882262859 @default.
- W4366281314 cites W1969999847 @default.
- W4366281314 cites W1971851698 @default.
- W4366281314 cites W1972557284 @default.
- W4366281314 cites W1973691524 @default.
- W4366281314 cites W1977434402 @default.
- W4366281314 cites W1979335914 @default.
- W4366281314 cites W1980725201 @default.
- W4366281314 cites W1983872945 @default.
- W4366281314 cites W1984529171 @default.
- W4366281314 cites W1985176813 @default.
- W4366281314 cites W1985696079 @default.
- W4366281314 cites W1985729602 @default.
- W4366281314 cites W1998216476 @default.
- W4366281314 cites W1999633852 @default.
- W4366281314 cites W2006054644 @default.
- W4366281314 cites W2012480020 @default.
- W4366281314 cites W2026392783 @default.
- W4366281314 cites W2027161175 @default.
- W4366281314 cites W2029729041 @default.
- W4366281314 cites W2034657285 @default.
- W4366281314 cites W2037159956 @default.
- W4366281314 cites W2065228191 @default.
- W4366281314 cites W2086749440 @default.
- W4366281314 cites W2087537136 @default.
- W4366281314 cites W2091391415 @default.
- W4366281314 cites W2107989274 @default.
- W4366281314 cites W2124272755 @default.
- W4366281314 cites W2137122394 @default.
- W4366281314 cites W2140424083 @default.
- W4366281314 cites W2154734157 @default.
- W4366281314 cites W2155933736 @default.
- W4366281314 cites W2158113006 @default.
- W4366281314 cites W2158152050 @default.
- W4366281314 cites W2162306347 @default.
- W4366281314 cites W2164947531 @default.
- W4366281314 cites W2166118277 @default.
- W4366281314 cites W2170832451 @default.
- W4366281314 cites W2324398051 @default.
- W4366281314 cites W2373868424 @default.
- W4366281314 cites W2565559032 @default.
- W4366281314 cites W2724407422 @default.
- W4366281314 cites W2761163803 @default.
- W4366281314 cites W2766588016 @default.
- W4366281314 cites W2767029153 @default.
- W4366281314 cites W2794294250 @default.
- W4366281314 cites W2885393602 @default.
- W4366281314 cites W2891675306 @default.
- W4366281314 cites W2901903386 @default.
- W4366281314 cites W2930463924 @default.
- W4366281314 cites W2970869050 @default.
- W4366281314 cites W2972340943 @default.
- W4366281314 cites W2984408637 @default.
- W4366281314 cites W3011983115 @default.
- W4366281314 cites W3022833266 @default.
- W4366281314 cites W3094515313 @default.
- W4366281314 cites W3124535662 @default.
- W4366281314 cites W4221111582 @default.
- W4366281314 cites W4225377331 @default.
- W4366281314 cites W4229037930 @default.
- W4366281314 doi "https://doi.org/10.1038/s42003-023-04640-5" @default.
- W4366281314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37072620" @default.
- W4366281314 hasPublicationYear "2023" @default.
- W4366281314 type Work @default.
- W4366281314 citedByCount "1" @default.
- W4366281314 countsByYear W43662813142023 @default.
- W4366281314 crossrefType "journal-article" @default.
- W4366281314 hasAuthorship W4366281314A5006739692 @default.
- W4366281314 hasAuthorship W4366281314A5023576389 @default.
- W4366281314 hasAuthorship W4366281314A5024867640 @default.
- W4366281314 hasAuthorship W4366281314A5028588562 @default.
- W4366281314 hasAuthorship W4366281314A5029057531 @default.
- W4366281314 hasAuthorship W4366281314A5067447552 @default.
- W4366281314 hasAuthorship W4366281314A5074398856 @default.
- W4366281314 hasAuthorship W4366281314A5076876397 @default.
- W4366281314 hasAuthorship W4366281314A5080070548 @default.
- W4366281314 hasAuthorship W4366281314A5083163427 @default.
- W4366281314 hasBestOaLocation W43662813141 @default.