FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366281433> ?p ?o ?g. }

• W4366281433 endingPage "2927" @default.
• W4366281433 startingPage "2927" @default.
• W4366281433 abstract "Doxycycline is a drug that has been proposed to modify osteoarthritis (OA) progression, in addition to its role as an antibiotic. However, available evidence thus far comprises sporadic reports, with no consensus on its benefits. Hence, this review attempts to analyze the evidence available thus far on the role of doxycycline as a disease-modifying osteoarthritis drug (DMOAD) in knee osteoarthritis. The earliest evidence of doxycycline in OA appeared in 1991 when doxycycline was found to inhibit the type XI collagenolytic activity of extracts from the human osteoarthritic cartilage, and gelatinase and tetracycline were found to inhibit this metalloproteinase activity in articular cartilage in vivo, which could modify cartilage breakdown in osteoarthritis. Apart from the inhibition of cartilage damage by metalloproteinases (MMPs) and other cartilage-related mechanisms, doxycycline also affects the bone and interferes with many enzyme systems. The most significant finding after reviewing various studies was that doxycycline has a definitive role in structural changes in osteoarthritis progression and radiological joint space width, but its role in the improvement of clinical outcomes as a DMOAD has not been established. However, there is much of a gap and lack of evidence in this regard. Doxycycline, as an MMP inhibitor, has theoretical advantages for clinical outcomes, but the present studies reveal only beneficial structural changes in osteoarthritis and very minimal or nonexistent advantages in clinical outcomes. Current evidence does not favor the regular use of doxycycline for the treatment of osteoarthritis as an individual treatment option or in combination with others. However, multicenter large cohort studies are warranted to determine the long-term benefits of doxycycline." @default.
• W4366281433 created "2023-04-20" @default.
• W4366281433 creator A5008502871 @default.
• W4366281433 creator A5049197837 @default.
• W4366281433 creator A5060028695 @default.
• W4366281433 creator A5063345999 @default.
• W4366281433 creator A5076909871 @default.
• W4366281433 date "2023-04-18" @default.
• W4366281433 modified "2023-09-26" @default.
• W4366281433 title "Role of Doxycycline as an Osteoarthritis Disease-Modifying Drug" @default.
• W4366281433 cites W1919122356 @default.
• W4366281433 cites W1932105426 @default.
• W4366281433 cites W1970735329 @default.
• W4366281433 cites W1972001109 @default.
• W4366281433 cites W2005381591 @default.
• W4366281433 cites W2023427354 @default.
• W4366281433 cites W2038981906 @default.
• W4366281433 cites W2050805899 @default.
• W4366281433 cites W2070087168 @default.
• W4366281433 cites W2070906225 @default.
• W4366281433 cites W2080843845 @default.
• W4366281433 cites W2081574718 @default.
• W4366281433 cites W2095852110 @default.
• W4366281433 cites W2103013342 @default.
• W4366281433 cites W2106921431 @default.
• W4366281433 cites W2119527637 @default.
• W4366281433 cites W2121686006 @default.
• W4366281433 cites W2126170959 @default.
• W4366281433 cites W2144966336 @default.
• W4366281433 cites W2149579818 @default.
• W4366281433 cites W2157930142 @default.
• W4366281433 cites W2239705084 @default.
• W4366281433 cites W2248431402 @default.
• W4366281433 cites W2340390214 @default.
• W4366281433 cites W2405309273 @default.
• W4366281433 cites W2414640364 @default.
• W4366281433 cites W2466377444 @default.
• W4366281433 cites W2791615560 @default.
• W4366281433 cites W2946885772 @default.
• W4366281433 cites W2969810988 @default.
• W4366281433 cites W2988845547 @default.
• W4366281433 cites W2996774074 @default.
• W4366281433 cites W2998486834 @default.
• W4366281433 cites W3002710359 @default.
• W4366281433 cites W3128044437 @default.
• W4366281433 cites W3128879566 @default.
• W4366281433 cites W3157256415 @default.
• W4366281433 cites W3214563279 @default.
• W4366281433 cites W4213290578 @default.
• W4366281433 cites W4224278302 @default.
• W4366281433 cites W4292707820 @default.
• W4366281433 cites W4295529515 @default.
• W4366281433 cites W4308958744 @default.
• W4366281433 cites W4310085954 @default.
• W4366281433 doi "https://doi.org/10.3390/jcm12082927" @default.
• W4366281433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37109263" @default.
• W4366281433 hasPublicationYear "2023" @default.
• W4366281433 type Work @default.
• W4366281433 citedByCount "1" @default.
• W4366281433 countsByYear W43662814332023 @default.
• W4366281433 crossrefType "journal-article" @default.
• W4366281433 hasAuthorship W4366281433A5008502871 @default.
• W4366281433 hasAuthorship W4366281433A5049197837 @default.
• W4366281433 hasAuthorship W4366281433A5060028695 @default.
• W4366281433 hasAuthorship W4366281433A5063345999 @default.
• W4366281433 hasAuthorship W4366281433A5076909871 @default.
• W4366281433 hasBestOaLocation W43662814331 @default.
• W4366281433 hasConcept C105702510 @default.
• W4366281433 hasConcept C109523444 @default.
• W4366281433 hasConcept C126322002 @default.
• W4366281433 hasConcept C142724271 @default.
• W4366281433 hasConcept C204787440 @default.
• W4366281433 hasConcept C2776164576 @default.
• W4366281433 hasConcept C2776232661 @default.
• W4366281433 hasConcept C2777179404 @default.
• W4366281433 hasConcept C2779134260 @default.
• W4366281433 hasConcept C2780035454 @default.
• W4366281433 hasConcept C2780550940 @default.
• W4366281433 hasConcept C501593827 @default.
• W4366281433 hasConcept C60644358 @default.
• W4366281433 hasConcept C71924100 @default.
• W4366281433 hasConcept C86803240 @default.
• W4366281433 hasConcept C89423630 @default.
• W4366281433 hasConcept C98274493 @default.
• W4366281433 hasConceptScore W4366281433C105702510 @default.
• W4366281433 hasConceptScore W4366281433C109523444 @default.
• W4366281433 hasConceptScore W4366281433C126322002 @default.
• W4366281433 hasConceptScore W4366281433C142724271 @default.
• W4366281433 hasConceptScore W4366281433C204787440 @default.
• W4366281433 hasConceptScore W4366281433C2776164576 @default.
• W4366281433 hasConceptScore W4366281433C2776232661 @default.
• W4366281433 hasConceptScore W4366281433C2777179404 @default.
• W4366281433 hasConceptScore W4366281433C2779134260 @default.
• W4366281433 hasConceptScore W4366281433C2780035454 @default.
• W4366281433 hasConceptScore W4366281433C2780550940 @default.
• W4366281433 hasConceptScore W4366281433C501593827 @default.
• W4366281433 hasConceptScore W4366281433C60644358 @default.
• W4366281433 hasConceptScore W4366281433C71924100 @default.

• next