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- W4366282672 abstract "Actin networks undergo rearrangements that influence cell and tissue shape. Actin network assembly and organization is regulated in space and time by a host of actin binding proteins. The Drosophila Synaptotagmin-like protein, Bitesize (Btsz), is known to organize actin at epithelial cell apical junctions in a manner that depends on its interaction with the actin-binding protein, Moesin. Here, we showed that Btsz functions in actin reorganization at earlier, syncytial stages of Drosophila embryo development. Btsz was required for the formation of stable metaphase pseudocleavage furrows that prevented spindle collisions and nuclear fallout prior to cellularization. While previous studies focused on Btsz isoforms containing the Moesin Binding Domain (MBD), we found that isoforms lacking the MBD also function in actin remodeling. Consistent with this, we found that the C-terminal half of BtszB cooperatively binds to and bundles F-actin, suggesting a direct mechanism for Synaptotagmin-like proteins regulating actin organization during animal development." @default.
- W4366282672 created "2023-04-20" @default.
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- W4366282672 date "2023-04-18" @default.
- W4366282672 modified "2023-09-27" @default.
- W4366282672 title "Bitesize bundles F-actin and influences actin remodeling in syncytial<i>Drosophila</i>embryo development" @default.
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- W4366282672 doi "https://doi.org/10.1101/2023.04.17.537198" @default.
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