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- W4366285812 endingPage "106683" @default.
- W4366285812 startingPage "106683" @default.
- W4366285812 abstract "CD4+ T cells are critical for adaptive immunity, differentiating into distinct effector and regulatory subsets. Although the transcriptional programs underlying their differentiation are known, recent research has highlighted the importance of mRNA translation in determining protein abundance. We previously conducted genome-wide analysis of translation in CD4+ T cells revealing distinct translational signatures distinguishing these subsets, identifying eIF4E as a central differentially translated transcript. As eIF4E is vital for eukaryotic translation, we examined how altered eIF4E activity affected T cell function using mice lacking eIF4E-binding proteins (BP-/-). BP-/- effector T cells showed elevated Th1 responses ex vivo and upon viral challenge with enhanced Th1 differentiation observed in vitro. This was accompanied by increased TCR activation and elevated glycolytic activity. This study highlights how regulating T cell-intrinsic eIF4E activity can influence T cell activation and differentiation, suggesting the eIF4EBP-eIF4E axis as a potential therapeutic target for controlling aberrant T cell responses." @default.
- W4366285812 created "2023-04-20" @default.
- W4366285812 creator A5012183033 @default.
- W4366285812 creator A5016827615 @default.
- W4366285812 creator A5037823807 @default.
- W4366285812 creator A5038114180 @default.
- W4366285812 creator A5039121080 @default.
- W4366285812 creator A5055669445 @default.
- W4366285812 date "2023-05-01" @default.
- W4366285812 modified "2023-09-30" @default.
- W4366285812 title "The eIF4EBP-eIF4E axis regulates CD4+ T cell differentiation through modulation of T cell activation and metabolism" @default.
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