FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366292014> ?p ?o ?g. }

• W4366292014 abstract "Introduction The H5N8 influenza virus is a highly pathogenic pathogen for poultry and human. Vaccination is the most effective method to control the spread of the virus right now. The traditional inactivated vaccine, though well developed and used widely, is laborious during application and more interests are stimulated in developing alternative approaches. Methods In this study, we developed three hemagglutinin (HA) gene-based yeast vaccine. In order to explore the protective efficacy of the vaccines, the gene expression level in the bursa of Fabricius and the structure of intestinal microflora in immunized animals were analyzed by RNA seq and 16SrRNA sequencing, and the regulatory mechanism of yeast vaccine was evaluated. Results All of these vaccines elicited the humoral immunity, inhibited viral load in the chicken tissues, and provided partial protective efficacy due to the high dose of the H5N8 virus. Molecular mechanism studies suggested that, compared to the traditional inactivated vaccine, our engineered yeast vaccine reshaped the immune cell microenvironment in bursa of Fabricius to promote the defense and immune responses. Analysis of gut microbiota further suggested that oral administration of engineered ST1814G/H5HA yeast vaccine increased the diversity of gut microbiota and the increasement of Reuteri and Muciniphila might benefit the recovery from influenza virus infection. These results provide strong evidence for further clinical use of these engineered yeast vaccine in poultry." @default.
• W4366292014 created "2023-04-20" @default.
• W4366292014 creator A5024605090 @default.
• W4366292014 creator A5046720938 @default.
• W4366292014 creator A5050852420 @default.
• W4366292014 creator A5063424279 @default.
• W4366292014 creator A5068547661 @default.
• W4366292014 creator A5071540643 @default.
• W4366292014 creator A5071547862 @default.
• W4366292014 creator A5075745968 @default.
• W4366292014 creator A5091626862 @default.
• W4366292014 date "2023-04-18" @default.
• W4366292014 modified "2023-10-10" @default.
• W4366292014 title "Hemagglutinin expressed by yeast reshapes immune microenvironment and gut microbiota to trigger diverse anti-infection response in infected birds" @default.
• W4366292014 cites W1004619708 @default.
• W4366292014 cites W1692592874 @default.
• W4366292014 cites W1861787140 @default.
• W4366292014 cites W1964968781 @default.
• W4366292014 cites W1987052745 @default.
• W4366292014 cites W1990386476 @default.
• W4366292014 cites W2013230062 @default.
• W4366292014 cites W2014474007 @default.
• W4366292014 cites W2024699776 @default.
• W4366292014 cites W2027352386 @default.
• W4366292014 cites W2028935045 @default.
• W4366292014 cites W2064922270 @default.
• W4366292014 cites W2149074973 @default.
• W4366292014 cites W2159024015 @default.
• W4366292014 cites W2488049993 @default.
• W4366292014 cites W2566086857 @default.
• W4366292014 cites W2750825815 @default.
• W4366292014 cites W2888812509 @default.
• W4366292014 cites W2889461683 @default.
• W4366292014 cites W2913977796 @default.
• W4366292014 cites W2938410397 @default.
• W4366292014 cites W2946761187 @default.
• W4366292014 cites W3041664448 @default.
• W4366292014 cites W3090178764 @default.
• W4366292014 cites W3099469601 @default.
• W4366292014 cites W3102967988 @default.
• W4366292014 cites W3120584823 @default.
• W4366292014 cites W3128867972 @default.
• W4366292014 cites W3136123769 @default.
• W4366292014 cites W3156509878 @default.
• W4366292014 cites W3167600642 @default.
• W4366292014 cites W3187774023 @default.
• W4366292014 cites W4206124525 @default.
• W4366292014 cites W4210499809 @default.
• W4366292014 cites W4226076950 @default.
• W4366292014 cites W4282832958 @default.
• W4366292014 cites W4289397589 @default.
• W4366292014 cites W4296036191 @default.
• W4366292014 cites W4304190075 @default.
• W4366292014 cites W4306406986 @default.
• W4366292014 cites W4306728737 @default.
• W4366292014 cites W4308955898 @default.
• W4366292014 cites W4309725014 @default.
• W4366292014 cites W4310964715 @default.
• W4366292014 doi "https://doi.org/10.3389/fimmu.2023.1125190" @default.
• W4366292014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37143654" @default.
• W4366292014 hasPublicationYear "2023" @default.
• W4366292014 type Work @default.
• W4366292014 citedByCount "1" @default.
• W4366292014 countsByYear W43662920142023 @default.
• W4366292014 crossrefType "journal-article" @default.
• W4366292014 hasAuthorship W4366292014A5024605090 @default.
• W4366292014 hasAuthorship W4366292014A5046720938 @default.
• W4366292014 hasAuthorship W4366292014A5050852420 @default.
• W4366292014 hasAuthorship W4366292014A5063424279 @default.
• W4366292014 hasAuthorship W4366292014A5068547661 @default.
• W4366292014 hasAuthorship W4366292014A5071540643 @default.
• W4366292014 hasAuthorship W4366292014A5071547862 @default.
• W4366292014 hasAuthorship W4366292014A5075745968 @default.
• W4366292014 hasAuthorship W4366292014A5091626862 @default.
• W4366292014 hasBestOaLocation W43662920141 @default.
• W4366292014 hasConcept C159047783 @default.
• W4366292014 hasConcept C196978929 @default.
• W4366292014 hasConcept C203014093 @default.
• W4366292014 hasConcept C22070199 @default.
• W4366292014 hasConcept C2522874641 @default.
• W4366292014 hasConcept C2778692840 @default.
• W4366292014 hasConcept C2779341262 @default.
• W4366292014 hasConcept C539455810 @default.
• W4366292014 hasConcept C86803240 @default.
• W4366292014 hasConcept C8891405 @default.
• W4366292014 hasConcept C89423630 @default.
• W4366292014 hasConceptScore W4366292014C159047783 @default.
• W4366292014 hasConceptScore W4366292014C196978929 @default.
• W4366292014 hasConceptScore W4366292014C203014093 @default.
• W4366292014 hasConceptScore W4366292014C22070199 @default.
• W4366292014 hasConceptScore W4366292014C2522874641 @default.
• W4366292014 hasConceptScore W4366292014C2778692840 @default.
• W4366292014 hasConceptScore W4366292014C2779341262 @default.
• W4366292014 hasConceptScore W4366292014C539455810 @default.
• W4366292014 hasConceptScore W4366292014C86803240 @default.
• W4366292014 hasConceptScore W4366292014C8891405 @default.
• W4366292014 hasConceptScore W4366292014C89423630 @default.
• W4366292014 hasFunder F4320328964 @default.
• W4366292014 hasLocation W43662920141 @default.
• W4366292014 hasLocation W43662920142 @default.

• next