Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366292570> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4366292570 abstract "The outbreak of Bacterial blight (BB) caused by Xanthomonas oryzae (Xoo) generates substantial economic losses to agricultural production. Antibiotics application is a valuable measure to control this bacterial disease. However, microbial antibiotic resistance dramatically reduced antibiotic effectiveness. Identifying the resistance mechanism of Xoo to antibiotics and restoring antibiotic susceptibility is one of the crucial ways to solve this problem. This study employed a GC-MS-based metabolomic approach to reveal the differential metabolomics between a kasugamycin-susceptible Xoo strain (Z173-S) and a kasugamycin-resistant strain (Z173-R KA ). The metabolic mechanism of kasugamycin (KA) resistance in Xoo by GC–MS showed that the downregulation of the pyruvate cycle (P cycle) is a crucial feature of Z173-R KA resistance to KA. This conclusion was confirmed by the decreased enzyme activities and the related gene transcriptional level in the P cycle. Furfural (an inhibitor of pyruvate dehydrogenase) can effectively inhibit the P cycle and increase the resistance of Z173-R KA to KA. Moreover, exogenous alanine can reduce the resistance of Z173-R KA to KA by promoting the P cycle. Our work seems to be the first exploration of the mechanism of KA resistance in Xoo by GC–MS-based metabonomics approach. These results provide a new idea for developing metabolic regulation to address KA resistance in Xoo." @default.
- W4366292570 created "2023-04-20" @default.
- W4366292570 creator A5008400068 @default.
- W4366292570 creator A5010788737 @default.
- W4366292570 creator A5082869787 @default.
- W4366292570 creator A5089267363 @default.
- W4366292570 date "2023-04-18" @default.
- W4366292570 modified "2023-09-25" @default.
- W4366292570 title "Alanine-mediated P cycle boosting enhances the killing efficiency of kasugamycin on antibiotic-resistant Xanthomonas oryzae" @default.
- W4366292570 cites W1554321287 @default.
- W4366292570 cites W169088908 @default.
- W4366292570 cites W1974529123 @default.
- W4366292570 cites W2014573465 @default.
- W4366292570 cites W2024475468 @default.
- W4366292570 cites W2046385870 @default.
- W4366292570 cites W2062222093 @default.
- W4366292570 cites W2075423625 @default.
- W4366292570 cites W2088091096 @default.
- W4366292570 cites W2101700812 @default.
- W4366292570 cites W2102258368 @default.
- W4366292570 cites W2127909959 @default.
- W4366292570 cites W2136379371 @default.
- W4366292570 cites W2159607805 @default.
- W4366292570 cites W2178817454 @default.
- W4366292570 cites W2282048358 @default.
- W4366292570 cites W2411684155 @default.
- W4366292570 cites W2596515345 @default.
- W4366292570 cites W2792624183 @default.
- W4366292570 cites W2793325503 @default.
- W4366292570 cites W2797291475 @default.
- W4366292570 cites W2897747897 @default.
- W4366292570 cites W2913045108 @default.
- W4366292570 cites W2936130335 @default.
- W4366292570 cites W2961533280 @default.
- W4366292570 cites W2965743053 @default.
- W4366292570 cites W2980278431 @default.
- W4366292570 cites W2983898447 @default.
- W4366292570 cites W3016065047 @default.
- W4366292570 cites W3022981546 @default.
- W4366292570 cites W3025905296 @default.
- W4366292570 cites W3092245843 @default.
- W4366292570 cites W3099543505 @default.
- W4366292570 cites W3100208577 @default.
- W4366292570 cites W3110746711 @default.
- W4366292570 cites W3165719405 @default.
- W4366292570 cites W3178850866 @default.
- W4366292570 cites W3193905534 @default.
- W4366292570 cites W3200595954 @default.
- W4366292570 cites W3204896659 @default.
- W4366292570 cites W3206914213 @default.
- W4366292570 cites W4213193736 @default.
- W4366292570 cites W4214942203 @default.
- W4366292570 cites W4220921413 @default.
- W4366292570 cites W4246413700 @default.
- W4366292570 cites W4283795075 @default.
- W4366292570 cites W4284697247 @default.
- W4366292570 doi "https://doi.org/10.3389/fmicb.2023.1160702" @default.
- W4366292570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37143533" @default.
- W4366292570 hasPublicationYear "2023" @default.
- W4366292570 type Work @default.
- W4366292570 citedByCount "0" @default.
- W4366292570 crossrefType "journal-article" @default.
- W4366292570 hasAuthorship W4366292570A5008400068 @default.
- W4366292570 hasAuthorship W4366292570A5010788737 @default.
- W4366292570 hasAuthorship W4366292570A5082869787 @default.
- W4366292570 hasAuthorship W4366292570A5089267363 @default.
- W4366292570 hasBestOaLocation W43662925701 @default.
- W4366292570 hasConcept C2776460866 @default.
- W4366292570 hasConcept C2776964914 @default.
- W4366292570 hasConcept C501593827 @default.
- W4366292570 hasConcept C86803240 @default.
- W4366292570 hasConcept C89423630 @default.
- W4366292570 hasConcept C94665300 @default.
- W4366292570 hasConceptScore W4366292570C2776460866 @default.
- W4366292570 hasConceptScore W4366292570C2776964914 @default.
- W4366292570 hasConceptScore W4366292570C501593827 @default.
- W4366292570 hasConceptScore W4366292570C86803240 @default.
- W4366292570 hasConceptScore W4366292570C89423630 @default.
- W4366292570 hasConceptScore W4366292570C94665300 @default.
- W4366292570 hasFunder F4320321001 @default.
- W4366292570 hasLocation W43662925701 @default.
- W4366292570 hasLocation W43662925702 @default.
- W4366292570 hasLocation W43662925703 @default.
- W4366292570 hasOpenAccess W4366292570 @default.
- W4366292570 hasPrimaryLocation W43662925701 @default.
- W4366292570 hasRelatedWork W2029063045 @default.
- W4366292570 hasRelatedWork W2076505260 @default.
- W4366292570 hasRelatedWork W2401291924 @default.
- W4366292570 hasRelatedWork W2507683919 @default.
- W4366292570 hasRelatedWork W2955020749 @default.
- W4366292570 hasRelatedWork W4205293155 @default.
- W4366292570 hasRelatedWork W4226193097 @default.
- W4366292570 hasRelatedWork W4229455480 @default.
- W4366292570 hasRelatedWork W4285542024 @default.
- W4366292570 hasRelatedWork W4320037900 @default.
- W4366292570 hasVolume "14" @default.
- W4366292570 isParatext "false" @default.
- W4366292570 isRetracted "false" @default.
- W4366292570 workType "article" @default.