Matches in SemOpenAlex for { <https://semopenalex.org/work/W43663324> ?p ?o ?g. }
- W43663324 endingPage "1082" @default.
- W43663324 startingPage "1072" @default.
- W43663324 abstract "The addition of microbial beta-galactosidases directly to milk at mealtime represents a potential enzyme replacement therapy for primary lactase deficiency. We used the hydrogen breath test as the index of incomplete carbohydrate absorption to assess the efficacy of two enzymes--one from yeast, Kluyveromyces lactis (LactAid), and the other from the fungus Aspergillus niger (Lactase N)--to assist in the hydrolysis of 18 g of lactose in 360 ml (12 oz) of whole milk when consumed by an adult lactose malabsorber. Graded amounts of Lactase N produced, at best, a 53% relative reduction in breath hydrogen excretion, whereas quantitative elimination of excess hydrogen excretion was produced by 1 and 1.5 g of LactAid. A double-blind, controlled, crossover trial was subsequently performed in 50 healthy, unselected Mexican adults, to whom 360 ml of cow's milk was presented in the three forms in a randomized order: intact milk, prehydrolyzed milk, and milk to which 1 g of LactAid was added immediately before consumption. Among the 25 subjects with incomplete carbohydrate absorption with intact milk, adding enzyme 5-min before consumption produced a 62% reduction in breath hydrogen excretion, and symptoms of intolerance were significantly reduced. The feasibility of effective enzyme replacement therapy with a beta-galactosidase from K. lactis is demonstrated." @default.
- W43663324 created "2016-06-24" @default.
- W43663324 creator A5014698720 @default.
- W43663324 creator A5027972901 @default.
- W43663324 creator A5031335334 @default.
- W43663324 creator A5034532946 @default.
- W43663324 date "1984-11-01" @default.
- W43663324 modified "2023-10-16" @default.
- W43663324 title "Enzyme Replacement Therapy for Primary Adult Lactase Deficiency" @default.
- W43663324 cites W12706981 @default.
- W43663324 cites W1528056035 @default.
- W43663324 cites W1603838400 @default.
- W43663324 cites W1649051875 @default.
- W43663324 cites W1758875560 @default.
- W43663324 cites W1771390547 @default.
- W43663324 cites W1783761218 @default.
- W43663324 cites W1793460836 @default.
- W43663324 cites W1817529529 @default.
- W43663324 cites W1833578135 @default.
- W43663324 cites W1889713250 @default.
- W43663324 cites W1911730375 @default.
- W43663324 cites W1933480563 @default.
- W43663324 cites W1959862500 @default.
- W43663324 cites W1974603862 @default.
- W43663324 cites W1980411008 @default.
- W43663324 cites W1993100251 @default.
- W43663324 cites W2003735595 @default.
- W43663324 cites W2021725546 @default.
- W43663324 cites W2024104003 @default.
- W43663324 cites W2028778170 @default.
- W43663324 cites W2042363530 @default.
- W43663324 cites W2054028187 @default.
- W43663324 cites W2069339312 @default.
- W43663324 cites W2070752353 @default.
- W43663324 cites W2080794790 @default.
- W43663324 cites W2086263688 @default.
- W43663324 cites W2087432801 @default.
- W43663324 cites W2092542992 @default.
- W43663324 cites W2105799984 @default.
- W43663324 cites W2118914429 @default.
- W43663324 cites W2130525821 @default.
- W43663324 cites W2144128717 @default.
- W43663324 cites W2147604986 @default.
- W43663324 cites W2159234713 @default.
- W43663324 cites W2166150498 @default.
- W43663324 cites W2176113649 @default.
- W43663324 cites W2205094789 @default.
- W43663324 cites W2259694022 @default.
- W43663324 cites W2263130223 @default.
- W43663324 cites W2285069465 @default.
- W43663324 cites W2323372612 @default.
- W43663324 cites W2332352723 @default.
- W43663324 cites W2340048307 @default.
- W43663324 doi "https://doi.org/10.1016/s0016-5085(84)80067-0" @default.
- W43663324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6434367" @default.
- W43663324 hasPublicationYear "1984" @default.
- W43663324 type Work @default.
- W43663324 sameAs 43663324 @default.
- W43663324 citedByCount "85" @default.
- W43663324 countsByYear W436633242012 @default.
- W43663324 countsByYear W436633242013 @default.
- W43663324 countsByYear W436633242014 @default.
- W43663324 countsByYear W436633242015 @default.
- W43663324 countsByYear W436633242016 @default.
- W43663324 countsByYear W436633242017 @default.
- W43663324 countsByYear W436633242019 @default.
- W43663324 countsByYear W436633242020 @default.
- W43663324 countsByYear W436633242021 @default.
- W43663324 countsByYear W436633242022 @default.
- W43663324 crossrefType "journal-article" @default.
- W43663324 hasAuthorship W43663324A5014698720 @default.
- W43663324 hasAuthorship W43663324A5027972901 @default.
- W43663324 hasAuthorship W43663324A5031335334 @default.
- W43663324 hasAuthorship W43663324A5034532946 @default.
- W43663324 hasBestOaLocation W436633241 @default.
- W43663324 hasConcept C10146269 @default.
- W43663324 hasConcept C126322002 @default.
- W43663324 hasConcept C134018914 @default.
- W43663324 hasConcept C181199279 @default.
- W43663324 hasConcept C185592680 @default.
- W43663324 hasConcept C2777432071 @default.
- W43663324 hasConcept C2778724459 @default.
- W43663324 hasConcept C2778974006 @default.
- W43663324 hasConcept C2778977261 @default.
- W43663324 hasConcept C31903555 @default.
- W43663324 hasConcept C55493867 @default.
- W43663324 hasConcept C71924100 @default.
- W43663324 hasConceptScore W43663324C10146269 @default.
- W43663324 hasConceptScore W43663324C126322002 @default.
- W43663324 hasConceptScore W43663324C134018914 @default.
- W43663324 hasConceptScore W43663324C181199279 @default.
- W43663324 hasConceptScore W43663324C185592680 @default.
- W43663324 hasConceptScore W43663324C2777432071 @default.
- W43663324 hasConceptScore W43663324C2778724459 @default.
- W43663324 hasConceptScore W43663324C2778974006 @default.
- W43663324 hasConceptScore W43663324C2778977261 @default.
- W43663324 hasConceptScore W43663324C31903555 @default.
- W43663324 hasConceptScore W43663324C55493867 @default.