Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366333060> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W4366333060 endingPage "9" @default.
- W4366333060 startingPage "6" @default.
- W4366333060 abstract "Annotation. The decisive place in the synthesis and subsequent metabolism of homocysteine (Hcy) belongs to the liver, where, in particular, transsulfation and remethylation processes take place. It has been proven that organ tissue damage can cause hyperhomocysteinemia (HHcy). Changes in the structural and functional parameters of the liver tissue under the conditions of a significant and long-term increase in blood serum Hcy are still insufficiently studied. Modeling the state of chronic HHcy and studying the features of histological changes in liver tissue at different levels of structural organization is an urgent task. The aim of the research is to study morphological and histochemical changes in the liver tissue of young rats with HHcy. The experiment was carried out on 22 white non-linear young – aged 1-2 months, male rats. During the study, the animals were divided into two groups – control and experimental. Chronic persistent HHcy was modeled by administering thiolactone Hcy in a dose of 200 mg/kg of body weight intragastrically for 60 days to the rats of the experimental group. Histological preparations were studied using a SEO SСAN light microscope and photo-documented using a Vision CCD Camera. Succinate dehydrogenase was detected histochemically according to the Nakhlas method. To study the specifics of glycogen accumulation in hepatocytes, sections were stained using Schiff's reagent, after preliminary treatment with iodic acid (PAS reaction) in the Shabadash modification. It was established that the administration of thiolactone Hcy to young rats at a dose of 200 mg/kg led to impaired blood supply, destructive changes and growth of connective tissue in the liver. Moderate changes in the hepatocyte plates organization, a decrease in the mitotic activity of hepatocytes, and the development of fatty and vacuole-hydropic dystrophy were recorded. Histochemical studies of the liver of animals of the research group established a decrease in the activity of the succinate dehydrogenase enzyme and glycogen content in hepatocytes." @default.
- W4366333060 created "2023-04-20" @default.
- W4366333060 creator A5091900369 @default.
- W4366333060 date "2023-02-25" @default.
- W4366333060 modified "2023-09-26" @default.
- W4366333060 title "Histological and histochemical changes in liver tissue of young rats with hyperhomocysteinemia" @default.
- W4366333060 doi "https://doi.org/10.31393/reports-vnmedical-2023-27(1)-01" @default.
- W4366333060 hasPublicationYear "2023" @default.
- W4366333060 type Work @default.
- W4366333060 citedByCount "0" @default.
- W4366333060 crossrefType "journal-article" @default.
- W4366333060 hasAuthorship W4366333060A5091900369 @default.
- W4366333060 hasBestOaLocation W43663330601 @default.
- W4366333060 hasConcept C126322002 @default.
- W4366333060 hasConcept C134018914 @default.
- W4366333060 hasConcept C142724271 @default.
- W4366333060 hasConcept C2776523773 @default.
- W4366333060 hasConcept C2777090595 @default.
- W4366333060 hasConcept C2777499176 @default.
- W4366333060 hasConcept C2780912031 @default.
- W4366333060 hasConcept C2992176824 @default.
- W4366333060 hasConcept C515207424 @default.
- W4366333060 hasConcept C55493867 @default.
- W4366333060 hasConcept C71924100 @default.
- W4366333060 hasConcept C86803240 @default.
- W4366333060 hasConceptScore W4366333060C126322002 @default.
- W4366333060 hasConceptScore W4366333060C134018914 @default.
- W4366333060 hasConceptScore W4366333060C142724271 @default.
- W4366333060 hasConceptScore W4366333060C2776523773 @default.
- W4366333060 hasConceptScore W4366333060C2777090595 @default.
- W4366333060 hasConceptScore W4366333060C2777499176 @default.
- W4366333060 hasConceptScore W4366333060C2780912031 @default.
- W4366333060 hasConceptScore W4366333060C2992176824 @default.
- W4366333060 hasConceptScore W4366333060C515207424 @default.
- W4366333060 hasConceptScore W4366333060C55493867 @default.
- W4366333060 hasConceptScore W4366333060C71924100 @default.
- W4366333060 hasConceptScore W4366333060C86803240 @default.
- W4366333060 hasIssue "1" @default.
- W4366333060 hasLocation W43663330601 @default.
- W4366333060 hasOpenAccess W4366333060 @default.
- W4366333060 hasPrimaryLocation W43663330601 @default.
- W4366333060 hasRelatedWork W1974827801 @default.
- W4366333060 hasRelatedWork W1980253981 @default.
- W4366333060 hasRelatedWork W2000228184 @default.
- W4366333060 hasRelatedWork W2011446445 @default.
- W4366333060 hasRelatedWork W2026634254 @default.
- W4366333060 hasRelatedWork W2051592475 @default.
- W4366333060 hasRelatedWork W2078769171 @default.
- W4366333060 hasRelatedWork W2153998249 @default.
- W4366333060 hasRelatedWork W2355150080 @default.
- W4366333060 hasRelatedWork W2758750505 @default.
- W4366333060 hasVolume "27" @default.
- W4366333060 isParatext "false" @default.
- W4366333060 isRetracted "false" @default.
- W4366333060 workType "article" @default.