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- W4366333073 abstract "Abstract The murine bone marrow has a central role in immune function and health as the primary source of leukocytes in adult mice. Laboratory mice provide a human-homologous, genetically manipulable and reproducible model that has enabled an immeasurable volume of high-quality immunological research. However, recent research has questioned the translatability of laboratory mouse research into humans and proposed that the exposure of mice to their wild and natural environment may hold the key to further immunological breakthroughs. To date there have been no studies providing an in-depth cellular analysis of the wild mouse bone marrow. This study utilised wild mice from an isolated island population (Isle of May, Scotland, United Kingdom) and performed flow cytometric and histological analysis to characterise the myeloid, lymphoid, hematopoietic progenitor, and adipocyte compartments within the wild mouse bone marrow. We find that, compared to laboratory mouse bone marrow, the wild mouse bone marrow differs in every cell type assessed. Some of the major distinctions include; a smaller B cell compartment with an enriched presence of plasma cells, increased proportions of KLRG1+ CD8+ T cells, diminished CD11b expression in the myeloid lineage and a five-fold enlargement of the eosinophil compartment. We conclude that the wild mouse bone marrow is dramatically distinct from its laboratory counterparts, with multiple phenotypes that to our knowledge have never been observed in laboratory models. Further research into these unique features may uncover novel immunological mechanisms and grant a greater understanding of the role of the immune system in a natural setting." @default.
- W4366333073 created "2023-04-20" @default.
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- W4366333073 date "2023-04-18" @default.
- W4366333073 modified "2023-09-30" @default.
- W4366333073 title "The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype" @default.
- W4366333073 doi "https://doi.org/10.1093/discim/kyad005" @default.
- W4366333073 hasPublicationYear "2023" @default.
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