FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366333653> ?p ?o ?g. }

• W4366333653 endingPage "000" @default.
• W4366333653 startingPage "000" @default.
• W4366333653 abstract "Prolyl endopeptidase (PREP) is a serine endopeptidase that participates in many pathological processes including inflammation, oxidative stress, and autophagy. Our previous studies found that PREP knockout exhibited multiple benefits in high-fat diet (HFD) or methionine choline-deficient diet-induced metabolic dysfunction-associated fatty liver disease (MAFLD). However, cumulative studies have suggested that PREP performs complex functions during disease development. Therefore, further understanding the role of PREP in MAFLD development is the foundation of PREP intervention.In this study, an HFD-induced MAFLD model at different time points (4, 8, 12, and 16 weeks) was used to explore dynamic changes in the PREP proline-glycine-proline (PGP)/N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) system. To explore its potential value in MAFLD treatment, saline, or the PREP inhibitor, KYP-2047, was administered to HFD-induced MAFLD mice from the 10th to 16th weeks.PREP activity and expression were increased in HFD-mice compared with control mice from the 12th week onwards, and increased PREP mainly resulted in the activation of the matrix metalloproteinase 8/9 (MMP8/9)-PREP-PGP axis rather than the thymosin β4-meprin α/PREP-AcSDKP axis. In addition, KYP-2047 reduced HFD-induced liver injury and oxidative stress, improved lipid metabolism through the suppression of lipogenic genes and the induction of β-oxidation-related genes, and attenuated hepatic inflammation by decreasing MMP8/9 and PGP. Moreover, KYP2047 restored HFD-induced impaired autophagy and this was verified in HepG2 cells.These findings suggest that increased PREP activity/expression during MAFLD development might be a key factor in the transition from simple steatosis to steatohepatitis, and KYP-2047 might possess therapeutic potential for MAFLD treatment." @default.
• W4366333653 created "2023-04-20" @default.
• W4366333653 creator A5007978364 @default.
• W4366333653 creator A5008388493 @default.
• W4366333653 creator A5012714371 @default.
• W4366333653 creator A5046201209 @default.
• W4366333653 creator A5065853314 @default.
• W4366333653 creator A5075064007 @default.
• W4366333653 date "2023-04-19" @default.
• W4366333653 modified "2023-10-14" @default.
• W4366333653 title "Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty Liver Disease" @default.
• W4366333653 cites W1910308666 @default.
• W4366333653 cites W1944935837 @default.
• W4366333653 cites W1992500134 @default.
• W4366333653 cites W2011574523 @default.
• W4366333653 cites W2013524886 @default.
• W4366333653 cites W2029295535 @default.
• W4366333653 cites W2052067496 @default.
• W4366333653 cites W2054036316 @default.
• W4366333653 cites W2067740038 @default.
• W4366333653 cites W2074246682 @default.
• W4366333653 cites W2086657936 @default.
• W4366333653 cites W2091297212 @default.
• W4366333653 cites W2091651967 @default.
• W4366333653 cites W2103661983 @default.
• W4366333653 cites W2112399469 @default.
• W4366333653 cites W2121065389 @default.
• W4366333653 cites W2146124002 @default.
• W4366333653 cites W2160234571 @default.
• W4366333653 cites W2166562100 @default.
• W4366333653 cites W2204688218 @default.
• W4366333653 cites W2288087911 @default.
• W4366333653 cites W2295127138 @default.
• W4366333653 cites W2502991882 @default.
• W4366333653 cites W2514570945 @default.
• W4366333653 cites W2537544611 @default.
• W4366333653 cites W2560138349 @default.
• W4366333653 cites W2571212804 @default.
• W4366333653 cites W2607031541 @default.
• W4366333653 cites W2801929531 @default.
• W4366333653 cites W2803123594 @default.
• W4366333653 cites W2804042740 @default.
• W4366333653 cites W2811264456 @default.
• W4366333653 cites W2871293796 @default.
• W4366333653 cites W2909135489 @default.
• W4366333653 cites W2940749702 @default.
• W4366333653 cites W2981129394 @default.
• W4366333653 cites W2981374393 @default.
• W4366333653 cites W2991513562 @default.
• W4366333653 cites W3013616343 @default.
• W4366333653 cites W3015579983 @default.
• W4366333653 cites W3022505015 @default.
• W4366333653 cites W3031976336 @default.
• W4366333653 cites W3126344921 @default.
• W4366333653 cites W3170875479 @default.
• W4366333653 cites W3183166775 @default.
• W4366333653 cites W3213204186 @default.
• W4366333653 cites W4200612130 @default.
• W4366333653 cites W4229440535 @default.
• W4366333653 cites W4255712601 @default.
• W4366333653 cites W3009242290 @default.
• W4366333653 doi "https://doi.org/10.14218/jcth.2022.00110" @default.
• W4366333653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37577240" @default.
• W4366333653 hasPublicationYear "2023" @default.
• W4366333653 type Work @default.
• W4366333653 citedByCount "0" @default.
• W4366333653 crossrefType "journal-article" @default.
• W4366333653 hasAuthorship W4366333653A5007978364 @default.
• W4366333653 hasAuthorship W4366333653A5008388493 @default.
• W4366333653 hasAuthorship W4366333653A5012714371 @default.
• W4366333653 hasAuthorship W4366333653A5046201209 @default.
• W4366333653 hasAuthorship W4366333653A5065853314 @default.
• W4366333653 hasAuthorship W4366333653A5075064007 @default.
• W4366333653 hasBestOaLocation W43663336531 @default.
• W4366333653 hasConcept C126322002 @default.
• W4366333653 hasConcept C134018914 @default.
• W4366333653 hasConcept C181199279 @default.
• W4366333653 hasConcept C185592680 @default.
• W4366333653 hasConcept C2776151105 @default.
• W4366333653 hasConcept C2776775109 @default.
• W4366333653 hasConcept C2776914184 @default.
• W4366333653 hasConcept C2778772119 @default.
• W4366333653 hasConcept C2779134260 @default.
• W4366333653 hasConcept C2780912031 @default.
• W4366333653 hasConcept C515207424 @default.
• W4366333653 hasConcept C55493867 @default.
• W4366333653 hasConcept C71924100 @default.
• W4366333653 hasConcept C98274493 @default.
• W4366333653 hasConceptScore W4366333653C126322002 @default.
• W4366333653 hasConceptScore W4366333653C134018914 @default.
• W4366333653 hasConceptScore W4366333653C181199279 @default.
• W4366333653 hasConceptScore W4366333653C185592680 @default.
• W4366333653 hasConceptScore W4366333653C2776151105 @default.
• W4366333653 hasConceptScore W4366333653C2776775109 @default.
• W4366333653 hasConceptScore W4366333653C2776914184 @default.
• W4366333653 hasConceptScore W4366333653C2778772119 @default.
• W4366333653 hasConceptScore W4366333653C2779134260 @default.
• W4366333653 hasConceptScore W4366333653C2780912031 @default.

• next