Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366334928> ?p ?o ?g. }
- W4366334928 abstract "Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and important for targeted delivery of biologics. We describe the design of octahedral non-porous nanoparticles with the three symmetry axes (four-fold, three-fold, and two-fold) occupied by three distinct protein homooligomers: a de novo designed tetramer, an antibody of interest, and a designed trimer programmed to disassemble below a tunable pH transition point. The nanoparticles assemble cooperatively from independently purified components, and a cryo-EM density map reveals that the structure is very close to the computational design model. The designed nanoparticles can package a variety of molecular payloads, are endocytosed following antibody-mediated targeting of cell surface receptors, and undergo tunable pH-dependent disassembly at pH values ranging between to 5.9-6.7. To our knowledge, these are the first designed nanoparticles with more than two structural components and with finely tunable environmental sensitivity, and they provide new routes to antibody-directed targeted delivery." @default.
- W4366334928 created "2023-04-20" @default.
- W4366334928 creator A5000033823 @default.
- W4366334928 creator A5001626969 @default.
- W4366334928 creator A5003066216 @default.
- W4366334928 creator A5013293317 @default.
- W4366334928 creator A5013999795 @default.
- W4366334928 creator A5014711271 @default.
- W4366334928 creator A5014867478 @default.
- W4366334928 creator A5016851342 @default.
- W4366334928 creator A5025168390 @default.
- W4366334928 creator A5038302116 @default.
- W4366334928 creator A5038502208 @default.
- W4366334928 creator A5038946848 @default.
- W4366334928 creator A5044419357 @default.
- W4366334928 creator A5044859694 @default.
- W4366334928 creator A5046648996 @default.
- W4366334928 creator A5046728930 @default.
- W4366334928 creator A5049142440 @default.
- W4366334928 creator A5049998286 @default.
- W4366334928 creator A5053192926 @default.
- W4366334928 creator A5053447291 @default.
- W4366334928 creator A5055284343 @default.
- W4366334928 creator A5060154356 @default.
- W4366334928 creator A5062715025 @default.
- W4366334928 creator A5080942565 @default.
- W4366334928 creator A5087368548 @default.
- W4366334928 date "2023-04-18" @default.
- W4366334928 modified "2023-10-02" @default.
- W4366334928 title "Computational design of non-porous, pH-responsive antibody nanoparticles" @default.
- W4366334928 cites W1964275463 @default.
- W4366334928 cites W1978269713 @default.
- W4366334928 cites W2025592853 @default.
- W4366334928 cites W2041399264 @default.
- W4366334928 cites W2047535887 @default.
- W4366334928 cites W2056034415 @default.
- W4366334928 cites W2073217307 @default.
- W4366334928 cites W2075987376 @default.
- W4366334928 cites W2108791168 @default.
- W4366334928 cites W2113495611 @default.
- W4366334928 cites W2132184418 @default.
- W4366334928 cites W2147537878 @default.
- W4366334928 cites W2152863535 @default.
- W4366334928 cites W2347184327 @default.
- W4366334928 cites W2433987067 @default.
- W4366334928 cites W2491008760 @default.
- W4366334928 cites W2516258544 @default.
- W4366334928 cites W2538859158 @default.
- W4366334928 cites W2559565289 @default.
- W4366334928 cites W2559856762 @default.
- W4366334928 cites W2606565969 @default.
- W4366334928 cites W2772342852 @default.
- W4366334928 cites W2799961143 @default.
- W4366334928 cites W2887243151 @default.
- W4366334928 cites W2913212173 @default.
- W4366334928 cites W2944245644 @default.
- W4366334928 cites W2945776060 @default.
- W4366334928 cites W2981137429 @default.
- W4366334928 cites W3005779939 @default.
- W4366334928 cites W3020461036 @default.
- W4366334928 cites W3109746568 @default.
- W4366334928 cites W3128196163 @default.
- W4366334928 cites W3131093799 @default.
- W4366334928 cites W3148609706 @default.
- W4366334928 cites W3152922933 @default.
- W4366334928 cites W3156929038 @default.
- W4366334928 cites W3158191005 @default.
- W4366334928 cites W3171076461 @default.
- W4366334928 cites W3174963239 @default.
- W4366334928 cites W3188940990 @default.
- W4366334928 cites W3200176065 @default.
- W4366334928 cites W3202931255 @default.
- W4366334928 cites W3207010678 @default.
- W4366334928 cites W4206390074 @default.
- W4366334928 cites W4307446497 @default.
- W4366334928 doi "https://doi.org/10.1101/2023.04.17.537263" @default.
- W4366334928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37131615" @default.
- W4366334928 hasPublicationYear "2023" @default.
- W4366334928 type Work @default.
- W4366334928 citedByCount "0" @default.
- W4366334928 crossrefType "posted-content" @default.
- W4366334928 hasAuthorship W4366334928A5000033823 @default.
- W4366334928 hasAuthorship W4366334928A5001626969 @default.
- W4366334928 hasAuthorship W4366334928A5003066216 @default.
- W4366334928 hasAuthorship W4366334928A5013293317 @default.
- W4366334928 hasAuthorship W4366334928A5013999795 @default.
- W4366334928 hasAuthorship W4366334928A5014711271 @default.
- W4366334928 hasAuthorship W4366334928A5014867478 @default.
- W4366334928 hasAuthorship W4366334928A5016851342 @default.
- W4366334928 hasAuthorship W4366334928A5025168390 @default.
- W4366334928 hasAuthorship W4366334928A5038302116 @default.
- W4366334928 hasAuthorship W4366334928A5038502208 @default.
- W4366334928 hasAuthorship W4366334928A5038946848 @default.
- W4366334928 hasAuthorship W4366334928A5044419357 @default.
- W4366334928 hasAuthorship W4366334928A5044859694 @default.
- W4366334928 hasAuthorship W4366334928A5046648996 @default.
- W4366334928 hasAuthorship W4366334928A5046728930 @default.
- W4366334928 hasAuthorship W4366334928A5049142440 @default.
- W4366334928 hasAuthorship W4366334928A5049998286 @default.
- W4366334928 hasAuthorship W4366334928A5053192926 @default.