Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366335781> ?p ?o ?g. }
- W4366335781 abstract "The utility of spatial immunobiomarker quantitation in prognostication and therapeutic prediction is actively being investigated in triple-negative breast cancer (TNBC). Here, with high-plex quantitative digital spatial profiling, we map and quantitate intraepithelial and adjacent stromal tumor immune protein microenvironments in systemic treatment-naïve (female only) TNBC to assess the spatial context in immunobiomarker-based prediction of outcome. Immune protein profiles of CD45-rich and CD68-rich stromal microenvironments differ significantly. While they typically mirror adjacent, intraepithelial microenvironments, this is not uniformly true. In two TNBC cohorts, intraepithelial CD40 or HLA-DR enrichment associates with better outcomes, independently of stromal immune protein profiles or stromal TILs and other established prognostic variables. In contrast, intraepithelial or stromal microenvironment enrichment with IDO1 associates with improved survival irrespective of its spatial location. Antigen-presenting and T-cell activation states are inferred from eigenprotein scores. Such scores within the intraepithelial compartment interact with PD-L1 and IDO1 in ways that suggest prognostic and/or therapeutic potential. This characterization of the intrinsic spatial immunobiology of treatment-naïve TNBC highlights the importance of spatial microenvironments for biomarker quantitation to resolve intrinsic prognostic and predictive immune features and ultimately inform therapeutic strategies for clinically actionable immune biomarkers." @default.
- W4366335781 created "2023-04-20" @default.
- W4366335781 creator A5005801602 @default.
- W4366335781 creator A5006782806 @default.
- W4366335781 creator A5008659449 @default.
- W4366335781 creator A5008665323 @default.
- W4366335781 creator A5015019391 @default.
- W4366335781 creator A5016908886 @default.
- W4366335781 creator A5022850305 @default.
- W4366335781 creator A5026692399 @default.
- W4366335781 creator A5027858713 @default.
- W4366335781 creator A5031005364 @default.
- W4366335781 creator A5033544737 @default.
- W4366335781 creator A5047094317 @default.
- W4366335781 creator A5052187738 @default.
- W4366335781 creator A5059897100 @default.
- W4366335781 creator A5061360566 @default.
- W4366335781 creator A5065306642 @default.
- W4366335781 creator A5065433718 @default.
- W4366335781 creator A5069569795 @default.
- W4366335781 creator A5072734589 @default.
- W4366335781 creator A5082913203 @default.
- W4366335781 creator A5083904553 @default.
- W4366335781 creator A5085014608 @default.
- W4366335781 creator A5085436504 @default.
- W4366335781 creator A5086768069 @default.
- W4366335781 creator A5087508472 @default.
- W4366335781 creator A5090618504 @default.
- W4366335781 date "2023-04-18" @default.
- W4366335781 modified "2023-10-18" @default.
- W4366335781 title "Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer" @default.
- W4366335781 cites W1498931318 @default.
- W4366335781 cites W1596515083 @default.
- W4366335781 cites W1982488143 @default.
- W4366335781 cites W1985987855 @default.
- W4366335781 cites W2007916488 @default.
- W4366335781 cites W2039123767 @default.
- W4366335781 cites W2071204159 @default.
- W4366335781 cites W2096864872 @default.
- W4366335781 cites W2098683355 @default.
- W4366335781 cites W2100413206 @default.
- W4366335781 cites W2120431466 @default.
- W4366335781 cites W2124427232 @default.
- W4366335781 cites W2125885282 @default.
- W4366335781 cites W2134878729 @default.
- W4366335781 cites W2154879572 @default.
- W4366335781 cites W2266303842 @default.
- W4366335781 cites W2296828141 @default.
- W4366335781 cites W2320044125 @default.
- W4366335781 cites W2337944657 @default.
- W4366335781 cites W2560367415 @default.
- W4366335781 cites W2561597485 @default.
- W4366335781 cites W2572174216 @default.
- W4366335781 cites W2578528809 @default.
- W4366335781 cites W2745547213 @default.
- W4366335781 cites W2754821104 @default.
- W4366335781 cites W2762153201 @default.
- W4366335781 cites W2788142646 @default.
- W4366335781 cites W2790198255 @default.
- W4366335781 cites W2883806089 @default.
- W4366335781 cites W2890156321 @default.
- W4366335781 cites W2897014915 @default.
- W4366335781 cites W2897422388 @default.
- W4366335781 cites W2906851567 @default.
- W4366335781 cites W2909218971 @default.
- W4366335781 cites W2909799373 @default.
- W4366335781 cites W2910968383 @default.
- W4366335781 cites W2943298986 @default.
- W4366335781 cites W2949315168 @default.
- W4366335781 cites W2972816610 @default.
- W4366335781 cites W2994697502 @default.
- W4366335781 cites W3005471253 @default.
- W4366335781 cites W3006930853 @default.
- W4366335781 cites W3014675490 @default.
- W4366335781 cites W3014749569 @default.
- W4366335781 cites W3015118245 @default.
- W4366335781 cites W3017039519 @default.
- W4366335781 cites W3023701177 @default.
- W4366335781 cites W3093154039 @default.
- W4366335781 cites W3109853980 @default.
- W4366335781 cites W3132615309 @default.
- W4366335781 cites W3134382826 @default.
- W4366335781 cites W3147027586 @default.
- W4366335781 cites W3160460588 @default.
- W4366335781 cites W3171226246 @default.
- W4366335781 cites W3198493858 @default.
- W4366335781 cites W4214728613 @default.
- W4366335781 cites W4229079181 @default.
- W4366335781 cites W4281889146 @default.
- W4366335781 cites W4285992810 @default.
- W4366335781 doi "https://doi.org/10.1038/s41467-023-37806-0" @default.
- W4366335781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37072398" @default.
- W4366335781 hasPublicationYear "2023" @default.
- W4366335781 type Work @default.
- W4366335781 citedByCount "2" @default.
- W4366335781 countsByYear W43663357812023 @default.
- W4366335781 crossrefType "journal-article" @default.
- W4366335781 hasAuthorship W4366335781A5005801602 @default.
- W4366335781 hasAuthorship W4366335781A5006782806 @default.
- W4366335781 hasAuthorship W4366335781A5008659449 @default.