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• W4366336215 abstract "Abstract Aim [123I]-Ioflupane (DaTSCAN) has a high binding affinity to the dopamine (DA) transporter (DaT) and tenfold less affinity to serotonin (5-HT) transporter (SERT). Both neurotransmitters are considered to contribute to body weight regulation. This study assesses the association between Body Mass Index (BMI) and DaTSCAN availability in brain. Method Scans from 74 consecutive patients who had undergone DaTSCAN single-photon computed tomography-computed tomography (SPECT-CT were used to obtain semi and absolute quantitative data in several volumes of interest (VOIs). Relative semi-quantitative specific binding ratios (SBRs) from Chang attenuated SPECT were obtained from GE DaTQUANT. Absolute normalised concentration (NC) was calculated from attenuation/scatter corrected SPECT-CT images, using an adapted version of the EARL Ltd (European Association of Nuclear Medicine (EANM) Research 4 Life) template. Results SBRs did not correlate with BMI. However, NC values correlated negatively in the entire cohort, with the strongest correlation in the frontal (r= -0.649. p = 0.000), occipital (r= -0.555, p = 0.000) regions and pons (r= -0.555, p = 0.000). In the abnormal (n = 49) and SWEDD group (n = 11), NC of the frontal region was the most correlated with BMI (r= -0.570, p = 0.000; r=-0.813, p = 0.002, respectively). In the borderline group (n = 14), the left posterior putamen displayed the strongest correlation (r=-0.765, p = 0.001). Conclusion Absolute NC values demonstrate a strong inverse correlation with BMI, strongest in the extrastriatal regions. Due to the predominately non-overlapping distribution of DaT and SERT, this study suggests greater involvement of SERT in obesity with possible interplay with DA transmission." @default.
• W4366336215 created "2023-04-20" @default.
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• W4366336215 date "2023-04-18" @default.
• W4366336215 modified "2023-09-24" @default.
• W4366336215 title "Association between Body Mass Index (BMI) and [123I]-Ioflupane (DaTSCAN) availabilities in patients with parkinsonism using single-photon computed tomography-computed tomography (SPECT-CT)" @default.
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• W4366336215 doi "https://doi.org/10.21203/rs.3.rs-2780817/v1" @default.
• W4366336215 hasPublicationYear "2023" @default.
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