Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366337528> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4366337528 abstract "ABSTRACT Although nucleosome positioning is key to epigenetic regulation, how the DNA sequence contributes to positioning remains elusive, especially in the context of transcription direction. Analysis of nucleotide bases with respect to the nucleosomal DNA coordinates requires precise nucleosomal mapping information on the genome. However, currently available base-pair-resolution nucleosome maps based on cysteine-mediated chemical cleavage do not fully satisfy the requirement due to method-specific cleavage biases. Here, we generated a chimeric nucleosomal DNA model to achieve less-biased prediction. The model revealed that yeast protein-coding sequences have higher affinity for the promoter-proximal half of nucleosomes than for the distal half. Strikingly, peaks of calculated affinity scores for the promoter-proximal half periodically matched the first few nucleosome positions. Detailed analysis of nucleotide bases revealed that the AA dinucleotide in the left side of the top strand contributes to nucleosome detection frequency in intergenic regions, while the complementary dinucleotide TT is preferred in the other side. In contrast, the sense strand is AA-rich throughout the nucleosome coordinate in protein-coding regions, which is consistent with asymmetric affinity. These data suggest that eukaryotes have evolved DNA sequences with asymmetric affinity for nucleosome formation to maintain epigenetic integrity of protein-coding regions." @default.
- W4366337528 created "2023-04-20" @default.
- W4366337528 creator A5001962229 @default.
- W4366337528 creator A5032267670 @default.
- W4366337528 creator A5081546462 @default.
- W4366337528 date "2023-04-18" @default.
- W4366337528 modified "2023-10-17" @default.
- W4366337528 title "Asymmetric patterns of nucleosome positioning sequences in protein-coding regions" @default.
- W4366337528 cites W1971491328 @default.
- W4366337528 cites W1980971292 @default.
- W4366337528 cites W1984085338 @default.
- W4366337528 cites W1988997227 @default.
- W4366337528 cites W1992005588 @default.
- W4366337528 cites W2002197756 @default.
- W4366337528 cites W2018475069 @default.
- W4366337528 cites W2024280474 @default.
- W4366337528 cites W2038645974 @default.
- W4366337528 cites W2061111901 @default.
- W4366337528 cites W2063679723 @default.
- W4366337528 cites W2070273691 @default.
- W4366337528 cites W2083247529 @default.
- W4366337528 cites W2085759022 @default.
- W4366337528 cites W2114803986 @default.
- W4366337528 cites W2115219137 @default.
- W4366337528 cites W2124555115 @default.
- W4366337528 cites W2139548742 @default.
- W4366337528 cites W2144792857 @default.
- W4366337528 cites W2147078566 @default.
- W4366337528 cites W2158177848 @default.
- W4366337528 cites W2158430792 @default.
- W4366337528 cites W2295180956 @default.
- W4366337528 cites W2504339242 @default.
- W4366337528 cites W2522187359 @default.
- W4366337528 cites W2553449527 @default.
- W4366337528 cites W2766631448 @default.
- W4366337528 cites W2795625769 @default.
- W4366337528 cites W2796205786 @default.
- W4366337528 cites W2808216003 @default.
- W4366337528 cites W2894693380 @default.
- W4366337528 cites W2914140608 @default.
- W4366337528 cites W2921302196 @default.
- W4366337528 cites W2972542385 @default.
- W4366337528 cites W2972823446 @default.
- W4366337528 cites W2978726711 @default.
- W4366337528 cites W2990803388 @default.
- W4366337528 cites W2994672877 @default.
- W4366337528 cites W3033211951 @default.
- W4366337528 cites W3082521240 @default.
- W4366337528 cites W3092033798 @default.
- W4366337528 cites W3113121586 @default.
- W4366337528 cites W3128450527 @default.
- W4366337528 cites W3154384473 @default.
- W4366337528 cites W3154797449 @default.
- W4366337528 cites W3155966349 @default.
- W4366337528 cites W3157019717 @default.
- W4366337528 cites W3164493072 @default.
- W4366337528 cites W3168665078 @default.
- W4366337528 cites W3173289591 @default.
- W4366337528 cites W3192911955 @default.
- W4366337528 cites W4206328572 @default.
- W4366337528 cites W4293068298 @default.
- W4366337528 cites W4293569212 @default.
- W4366337528 doi "https://doi.org/10.1101/2023.04.16.537090" @default.
- W4366337528 hasPublicationYear "2023" @default.
- W4366337528 type Work @default.
- W4366337528 citedByCount "0" @default.
- W4366337528 crossrefType "posted-content" @default.
- W4366337528 hasAuthorship W4366337528A5001962229 @default.
- W4366337528 hasAuthorship W4366337528A5032267670 @default.
- W4366337528 hasAuthorship W4366337528A5081546462 @default.
- W4366337528 hasBestOaLocation W43663375281 @default.
- W4366337528 hasConcept C54355233 @default.
- W4366337528 hasConcept C552990157 @default.
- W4366337528 hasConcept C64927066 @default.
- W4366337528 hasConcept C70721500 @default.
- W4366337528 hasConcept C84772758 @default.
- W4366337528 hasConcept C86803240 @default.
- W4366337528 hasConceptScore W4366337528C54355233 @default.
- W4366337528 hasConceptScore W4366337528C552990157 @default.
- W4366337528 hasConceptScore W4366337528C64927066 @default.
- W4366337528 hasConceptScore W4366337528C70721500 @default.
- W4366337528 hasConceptScore W4366337528C84772758 @default.
- W4366337528 hasConceptScore W4366337528C86803240 @default.
- W4366337528 hasLocation W43663375281 @default.
- W4366337528 hasOpenAccess W4366337528 @default.
- W4366337528 hasPrimaryLocation W43663375281 @default.
- W4366337528 hasRelatedWork W103240388 @default.
- W4366337528 hasRelatedWork W1884733595 @default.
- W4366337528 hasRelatedWork W1966176240 @default.
- W4366337528 hasRelatedWork W2005959835 @default.
- W4366337528 hasRelatedWork W2011687492 @default.
- W4366337528 hasRelatedWork W2058695493 @default.
- W4366337528 hasRelatedWork W2064895995 @default.
- W4366337528 hasRelatedWork W2095778761 @default.
- W4366337528 hasRelatedWork W2910270211 @default.
- W4366337528 hasRelatedWork W4231023284 @default.
- W4366337528 isParatext "false" @default.
- W4366337528 isRetracted "false" @default.
- W4366337528 workType "article" @default.