Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366338950> ?p ?o ?g. }
- W4366338950 abstract "Limited numbers of available hematopoietic stem cells (HSCs) limit the widespread use of HSC-based therapies. Expansion systems for functional heterogenous HSCs remain to be optimized. Here, we present a convenient strategy for human HSC expansion based on a biomimetic Microniche. After demonstrating the expansion of HSC from different sources, we find that our Microniche-based system expands the therapeutically attractive megakaryocyte-biased HSC. We demonstrate scalable HSC expansion by applying this strategy in a stirred bioreactor. Moreover, we identify that the functional human megakaryocyte-biased HSCs are enriched in the CD34+CD38-CD45RA-CD90+CD49f lowCD62L-CD133+ subpopulation. Specifically, the expansion of megakaryocyte-biased HSCs is supported by a biomimetic niche-like microenvironment, which generates a suitable cytokine milieu and supplies the appropriate physical scaffolding. Thus, beyond clarifying the existence and immuno-phenotype of human megakaryocyte-biased HSC, our study demonstrates a flexible human HSC expansion strategy that could help realize the strong clinical promise of HSC-based therapies." @default.
- W4366338950 created "2023-04-20" @default.
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- W4366338950 date "2023-04-18" @default.
- W4366338950 modified "2023-10-14" @default.
- W4366338950 title "Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche" @default.
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- W4366338950 doi "https://doi.org/10.1038/s41467-023-37954-3" @default.
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- W4366338950 hasPublicationYear "2023" @default.
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