FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366346972> ?p ?o ?g. }

• W4366346972 endingPage "624" @default.
• W4366346972 startingPage "615" @default.
• W4366346972 abstract "The acid–base equilibria of six ACE inhibitors (ACEIs), captopril, cilazapril, enalapril, lisinopril, quinapril, and ramipril, were investigated in the presence of micelles of nonionic surfactant Brij 35. The pKa values were potentiometrically determined at 25 °C and at a constant ionic strength (0.1 M NaCl). The obtained potentiometric data were evaluated in the computer program Hyperquad. On the basis of the shift in the pKa values (ΔpKa) determined in micellar media in relation to the pKa values previously determined in “pure” water, the effect of Brij 35 micelles on ACEIs ionization was estimated. The presence of nonionic Brij 35 micelles caused a shift in the pKa values of all ionizable groups of the investigated ACEIs (ΔpKa from − 3.44 to + 1.9) while shifting the protolytic equilibria of both acidic and basic groups toward the molecular form. The Brij 35 micelles expressed the most pronounced effect on the ionization of captopril among the investigated ACEIs and stronger effect on the ionization of amino than on the ionization of carboxyl groups. The obtained results suggest that ionizable functional groups of ACEIs are involved in interactions with palisade layer of nonionic Brij 35 micelles, which potentially can be considered in physiological conditions. Distribution diagrams of the investigated ACEIs equilibrium forms as a function of pH indicate that the change in distribution is most strongly expressed in pH range 4–8, which includes biopharmaceutically important pH values." @default.
• W4366346972 created "2023-04-21" @default.
• W4366346972 creator A5030700214 @default.
• W4366346972 creator A5060632603 @default.
• W4366346972 creator A5074831593 @default.
• W4366346972 date "2023-04-18" @default.
• W4366346972 modified "2023-10-15" @default.
• W4366346972 title "Protolytic equilibria of ACE inhibitors in micellar solution of nonionic surfactant Brij 35" @default.
• W4366346972 cites W1978170982 @default.
• W4366346972 cites W1990069910 @default.
• W4366346972 cites W1991101882 @default.
• W4366346972 cites W2002996832 @default.
• W4366346972 cites W2018493376 @default.
• W4366346972 cites W2019129194 @default.
• W4366346972 cites W2023131478 @default.
• W4366346972 cites W2041427844 @default.
• W4366346972 cites W2045063255 @default.
• W4366346972 cites W2074066467 @default.
• W4366346972 cites W2077516301 @default.
• W4366346972 cites W2082769420 @default.
• W4366346972 cites W2086806820 @default.
• W4366346972 cites W2122970206 @default.
• W4366346972 cites W2138520198 @default.
• W4366346972 cites W2332110449 @default.
• W4366346972 cites W2332122397 @default.
• W4366346972 cites W2339191362 @default.
• W4366346972 cites W2462105175 @default.
• W4366346972 cites W2485283686 @default.
• W4366346972 cites W2492101850 @default.
• W4366346972 cites W2551896739 @default.
• W4366346972 cites W2561373907 @default.
• W4366346972 cites W2617956525 @default.
• W4366346972 cites W2755247557 @default.
• W4366346972 cites W2895820176 @default.
• W4366346972 cites W3012184818 @default.
• W4366346972 cites W3025972797 @default.
• W4366346972 cites W4242372416 @default.
• W4366346972 doi "https://doi.org/10.1007/s00706-023-03059-2" @default.
• W4366346972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37193115" @default.
• W4366346972 hasPublicationYear "2023" @default.
• W4366346972 type Work @default.
• W4366346972 citedByCount "0" @default.
• W4366346972 crossrefType "journal-article" @default.
• W4366346972 hasAuthorship W4366346972A5030700214 @default.
• W4366346972 hasAuthorship W4366346972A5060632603 @default.
• W4366346972 hasAuthorship W4366346972A5074831593 @default.
• W4366346972 hasBestOaLocation W43663469721 @default.
• W4366346972 hasConcept C11268172 @default.
• W4366346972 hasConcept C124614425 @default.
• W4366346972 hasConcept C126838900 @default.
• W4366346972 hasConcept C145148216 @default.
• W4366346972 hasConcept C178790620 @default.
• W4366346972 hasConcept C179104552 @default.
• W4366346972 hasConcept C184651966 @default.
• W4366346972 hasConcept C185592680 @default.
• W4366346972 hasConcept C187428577 @default.
• W4366346972 hasConcept C198291218 @default.
• W4366346972 hasConcept C22163223 @default.
• W4366346972 hasConcept C27016395 @default.
• W4366346972 hasConcept C2776992270 @default.
• W4366346972 hasConcept C2777880890 @default.
• W4366346972 hasConcept C2779611605 @default.
• W4366346972 hasConcept C2781352967 @default.
• W4366346972 hasConcept C55493867 @default.
• W4366346972 hasConcept C58226133 @default.
• W4366346972 hasConcept C71924100 @default.
• W4366346972 hasConcept C84393581 @default.
• W4366346972 hasConceptScore W4366346972C11268172 @default.
• W4366346972 hasConceptScore W4366346972C124614425 @default.
• W4366346972 hasConceptScore W4366346972C126838900 @default.
• W4366346972 hasConceptScore W4366346972C145148216 @default.
• W4366346972 hasConceptScore W4366346972C178790620 @default.
• W4366346972 hasConceptScore W4366346972C179104552 @default.
• W4366346972 hasConceptScore W4366346972C184651966 @default.
• W4366346972 hasConceptScore W4366346972C185592680 @default.
• W4366346972 hasConceptScore W4366346972C187428577 @default.
• W4366346972 hasConceptScore W4366346972C198291218 @default.
• W4366346972 hasConceptScore W4366346972C22163223 @default.
• W4366346972 hasConceptScore W4366346972C27016395 @default.
• W4366346972 hasConceptScore W4366346972C2776992270 @default.
• W4366346972 hasConceptScore W4366346972C2777880890 @default.
• W4366346972 hasConceptScore W4366346972C2779611605 @default.
• W4366346972 hasConceptScore W4366346972C2781352967 @default.
• W4366346972 hasConceptScore W4366346972C55493867 @default.
• W4366346972 hasConceptScore W4366346972C58226133 @default.
• W4366346972 hasConceptScore W4366346972C71924100 @default.
• W4366346972 hasConceptScore W4366346972C84393581 @default.
• W4366346972 hasFunder F4320322729 @default.
• W4366346972 hasIssue "6" @default.
• W4366346972 hasLocation W43663469721 @default.
• W4366346972 hasLocation W43663469722 @default.
• W4366346972 hasLocation W43663469723 @default.
• W4366346972 hasOpenAccess W4366346972 @default.
• W4366346972 hasPrimaryLocation W43663469721 @default.
• W4366346972 hasRelatedWork W1967771310 @default.
• W4366346972 hasRelatedWork W1983060123 @default.
• W4366346972 hasRelatedWork W2035685754 @default.
• W4366346972 hasRelatedWork W2082956760 @default.

• next