FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366351020> ?p ?o ?g. }

• W4366351020 endingPage "358" @default.
• W4366351020 startingPage "327" @default.
• W4366351020 abstract "Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) are the preferred regimen for patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced or metastatic breast cancer. However, the optimal treatment sequencing for CDK4/6i with other available therapeutic options is unclear. We conducted a targeted literature review to identify the current evidence on CDK4/6i treatment patterns in patients with breast cancer. The search was initially conducted in October 2021 and subsequently updated in October 2022. Biomedical databases and gray literature were searched, and bibliographies of included reviews were screened for relevant studies. The search identified ten reviews published since 2021 and 87 clinical trials or observational studies published since 2015. The included reviews discussed CDK4/6i usage with or without endocrine therapy (ET) in first-line and second-line treatment for patients with HR+/HER2− advanced or metastatic breast cancer, followed by ET, chemotherapy, or targeted therapy with ET. Clinical studies reported similar treatment sequences consisting of ET, chemotherapy, or targeted therapy with ET prior to CDK4/6i with ET, followed by ET monotherapy, chemotherapy, targeted therapy with ET, or continued CDK4/6i with ET. Current evidence suggests CDK4/6i are effective for HR+/HER2− advanced or metastatic breast cancer in earlier lines of therapy. Efficacy of CDK4/6i as measured by progression-free survival and overall survival was similar within a line of therapy regardless of the type of prior therapy. Survival on different post-CDK4/6i treatments was also similar within the same line of therapy. Additional research is needed to investigate the optimal place in therapy of CDK4/6i and the sequencing of treatments following progression on CDK4/6i." @default.
• W4366351020 created "2023-04-21" @default.
• W4366351020 creator A5022090319 @default.
• W4366351020 creator A5023278861 @default.
• W4366351020 creator A5040211938 @default.
• W4366351020 creator A5064545455 @default.
• W4366351020 creator A5077543689 @default.
• W4366351020 date "2023-04-19" @default.
• W4366351020 modified "2023-09-30" @default.
• W4366351020 title "Place in Therapy of Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer: A Targeted Literature Review" @default.
• W4366351020 cites W2082326948 @default.
• W4366351020 cites W2290950904 @default.
• W4366351020 cites W2528767298 @default.
• W4366351020 cites W2552099557 @default.
• W4366351020 cites W2752658156 @default.
• W4366351020 cites W2763875663 @default.
• W4366351020 cites W2772012471 @default.
• W4366351020 cites W2790923252 @default.
• W4366351020 cites W2804105316 @default.
• W4366351020 cites W2891975996 @default.
• W4366351020 cites W2897446380 @default.
• W4366351020 cites W2901270440 @default.
• W4366351020 cites W2905011561 @default.
• W4366351020 cites W2911188781 @default.
• W4366351020 cites W2916875993 @default.
• W4366351020 cites W2924345863 @default.
• W4366351020 cites W2938427670 @default.
• W4366351020 cites W2943438364 @default.
• W4366351020 cites W2944201768 @default.
• W4366351020 cites W2947236477 @default.
• W4366351020 cites W2947245065 @default.
• W4366351020 cites W2947251720 @default.
• W4366351020 cites W2947281735 @default.
• W4366351020 cites W2947864495 @default.
• W4366351020 cites W2947876005 @default.
• W4366351020 cites W2947918745 @default.
• W4366351020 cites W2947984984 @default.
• W4366351020 cites W2948069739 @default.
• W4366351020 cites W2976415870 @default.
• W4366351020 cites W2982289558 @default.
• W4366351020 cites W3001574063 @default.
• W4366351020 cites W3029560485 @default.
• W4366351020 cites W3033000211 @default.
• W4366351020 cites W3036616083 @default.
• W4366351020 cites W3044233866 @default.
• W4366351020 cites W3045133340 @default.
• W4366351020 cites W3048496731 @default.
• W4366351020 cites W3049324184 @default.
• W4366351020 cites W3082552926 @default.
• W4366351020 cites W3092326212 @default.
• W4366351020 cites W3093844978 @default.
• W4366351020 cites W3102390518 @default.
• W4366351020 cites W3104109358 @default.
• W4366351020 cites W3104936322 @default.
• W4366351020 cites W3109881382 @default.
• W4366351020 cites W3110070773 @default.
• W4366351020 cites W3111996377 @default.
• W4366351020 cites W3120241209 @default.
• W4366351020 cites W3121669596 @default.
• W4366351020 cites W3123867938 @default.
• W4366351020 cites W3124652262 @default.
• W4366351020 cites W3128646645 @default.
• W4366351020 cites W3133584322 @default.
• W4366351020 cites W3136702726 @default.
• W4366351020 cites W3137065215 @default.
• W4366351020 cites W3137610496 @default.
• W4366351020 cites W3137868312 @default.
• W4366351020 cites W3146142859 @default.
• W4366351020 cites W3148345241 @default.
• W4366351020 cites W3150678791 @default.
• W4366351020 cites W3158079634 @default.
• W4366351020 cites W3161555469 @default.
• W4366351020 cites W3162093234 @default.
• W4366351020 cites W3164989226 @default.
• W4366351020 cites W3165313225 @default.
• W4366351020 cites W3173788849 @default.
• W4366351020 cites W3175652738 @default.
• W4366351020 cites W3176047471 @default.
• W4366351020 cites W3184390979 @default.
• W4366351020 cites W3185610732 @default.
• W4366351020 cites W3185868618 @default.
• W4366351020 cites W3187471363 @default.
• W4366351020 cites W3189331974 @default.
• W4366351020 cites W3190031952 @default.
• W4366351020 cites W3190838900 @default.
• W4366351020 cites W3198586584 @default.
• W4366351020 cites W3202968750 @default.
• W4366351020 cites W3205289224 @default.
• W4366351020 cites W3207556705 @default.
• W4366351020 cites W3207557929 @default.
• W4366351020 cites W3215920069 @default.
• W4366351020 cites W4200136212 @default.
• W4366351020 cites W4205724345 @default.
• W4366351020 cites W4206349107 @default.
• W4366351020 cites W4206837320 @default.
• W4366351020 cites W4210295521 @default.
• W4366351020 cites W4210922561 @default.
• W4366351020 cites W4220666120 @default.

• next