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• W4366351427 endingPage "2759" @default.
• W4366351427 startingPage "2743" @default.
• W4366351427 abstract "Parkinson's disease (PD) is one of the most common degenerative brain disorders caused by the loss of dopaminergic neurons in the substantia nigra (SN). Lewy bodies and -synuclein accumulation in the SN are hallmarks of the neuropathology of PD. Due to lifestyle changes and prolonged L-dopa administration, patients with PD frequently have vitamin deficiencies, especially folate, vitamin B6, and vitamin B12. These disorders augment circulating levels of Homocysteine with the development of hyperhomocysteinemia, which may contribute to the pathogenesis of PD. Therefore, this review aimed to ascertain if hyperhomocysteinemia may play a part in oxidative and inflammatory signaling pathways that contribute to PD development. Hyperhomocysteinemia is implicated in the pathogenesis of neurodegenerative disorders, including PD. Hyperhomocysteinemia triggers the development and progression of PD by different mechanisms, including oxidative stress, mitochondrial dysfunction, apoptosis, and endothelial dysfunction. Particularly, the progression of PD is linked with high inflammatory changes and systemic inflammatory disorders. Hyperhomocysteinemia induces immune activation and oxidative stress. In turn, activated immune response promotes the development and progression of hyperhomocysteinemia. Therefore, hyperhomocysteinemia-induced immunoinflammatory disorders and abnormal immune response may aggravate abnormal immunoinflammatory in PD, leading to more progression of PD severity. Also, inflammatory signaling pathways like nuclear factor kappa B (NF-κB) and nod-like receptor pyrin 3 (NLRP3) inflammasome and other signaling pathways are intricate in the pathogenesis of PD. In conclusion, hyperhomocysteinemia is involved in the development and progression of PD neuropathology either directly via induction degeneration of dopaminergic neurons or indirectly via activation of inflammatory signaling pathways." @default.
• W4366351427 created "2023-04-21" @default.
• W4366351427 creator A5018176085 @default.
• W4366351427 creator A5019363285 @default.
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• W4366351427 creator A5053035419 @default.
• W4366351427 creator A5068241143 @default.
• W4366351427 creator A5090665178 @default.
• W4366351427 date "2023-04-19" @default.
• W4366351427 modified "2023-10-18" @default.
• W4366351427 title "Parkinson’s Disease Risk and Hyperhomocysteinemia: The Possible Link" @default.
• W4366351427 cites W1595038777 @default.
• W4366351427 cites W1825896320 @default.
• W4366351427 cites W1967934984 @default.
• W4366351427 cites W1969999276 @default.
• W4366351427 cites W1972483153 @default.
• W4366351427 cites W1975460771 @default.
• W4366351427 cites W1977407292 @default.
• W4366351427 cites W1979689847 @default.
• W4366351427 cites W1984169640 @default.
• W4366351427 cites W1986288479 @default.
• W4366351427 cites W1990007701 @default.
• W4366351427 cites W1991729739 @default.
• W4366351427 cites W2000111650 @default.
• W4366351427 cites W2001610698 @default.
• W4366351427 cites W2015283405 @default.
• W4366351427 cites W2017498013 @default.
• W4366351427 cites W2029085167 @default.
• W4366351427 cites W2034048630 @default.
• W4366351427 cites W2052588755 @default.
• W4366351427 cites W2057765028 @default.
• W4366351427 cites W2058421824 @default.
• W4366351427 cites W2060903223 @default.
• W4366351427 cites W2062953927 @default.
• W4366351427 cites W2063504429 @default.
• W4366351427 cites W2064290559 @default.
• W4366351427 cites W2065168778 @default.
• W4366351427 cites W2066762007 @default.
• W4366351427 cites W2074602389 @default.
• W4366351427 cites W2074768230 @default.
• W4366351427 cites W2075501574 @default.
• W4366351427 cites W2081216630 @default.
• W4366351427 cites W2081953468 @default.
• W4366351427 cites W2086084865 @default.
• W4366351427 cites W2086997247 @default.
• W4366351427 cites W2090138962 @default.
• W4366351427 cites W2095975236 @default.
• W4366351427 cites W2106709323 @default.
• W4366351427 cites W2108212314 @default.
• W4366351427 cites W2109594309 @default.
• W4366351427 cites W2110299170 @default.
• W4366351427 cites W2125123256 @default.
• W4366351427 cites W2126230337 @default.
• W4366351427 cites W2131668091 @default.
• W4366351427 cites W2134479104 @default.
• W4366351427 cites W2134605929 @default.
• W4366351427 cites W2139942606 @default.
• W4366351427 cites W2146934684 @default.
• W4366351427 cites W2149154883 @default.
• W4366351427 cites W2149612111 @default.
• W4366351427 cites W2154642316 @default.
• W4366351427 cites W2159532698 @default.
• W4366351427 cites W2163446898 @default.
• W4366351427 cites W2167100109 @default.
• W4366351427 cites W2183404009 @default.
• W4366351427 cites W2269860308 @default.
• W4366351427 cites W2292114276 @default.
• W4366351427 cites W2305031077 @default.
• W4366351427 cites W2326309657 @default.
• W4366351427 cites W2337420034 @default.
• W4366351427 cites W2472547513 @default.
• W4366351427 cites W2522054313 @default.
• W4366351427 cites W2531058430 @default.
• W4366351427 cites W2580817364 @default.
• W4366351427 cites W2592727629 @default.
• W4366351427 cites W2606314063 @default.
• W4366351427 cites W2737715512 @default.
• W4366351427 cites W2770200990 @default.
• W4366351427 cites W2792925662 @default.
• W4366351427 cites W2793462203 @default.
• W4366351427 cites W2810320898 @default.
• W4366351427 cites W2831688134 @default.
• W4366351427 cites W2861203326 @default.
• W4366351427 cites W2873344332 @default.
• W4366351427 cites W2893547774 @default.
• W4366351427 cites W2897212299 @default.
• W4366351427 cites W2897298828 @default.
• W4366351427 cites W2897810330 @default.
• W4366351427 cites W2898353408 @default.
• W4366351427 cites W2899082089 @default.
• W4366351427 cites W2906325447 @default.
• W4366351427 cites W2907424910 @default.
• W4366351427 cites W2911271268 @default.
• W4366351427 cites W2912023154 @default.
• W4366351427 cites W2912830999 @default.
• W4366351427 cites W2914058883 @default.
• W4366351427 cites W2915018933 @default.

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