FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366351444> ?p ?o ?g. }

• W4366351444 endingPage "723" @default.
• W4366351444 startingPage "715" @default.
• W4366351444 abstract "Microbial biofilms are resilient, immune-evasive, often antibiotic-resistant health challenges, and increasingly the target for research into novel therapeutic strategies. We evaluated the effects of a nutraceutical enzyme and botanical blend (NEBB) on established biofilm. Five microbial strains with known implications in chronic human illnesses were tested: Candida albicans, Staphylococcus aureus, Staphylococcus simulans (coagulase-negative, penicillin-resistant), Borrelia burgdorferi, and Pseudomonas aeruginosa. The strains were allowed to form biofilm in vitro. Biofilm cultures were treated with NEBB containing enzymes targeted at lipids, proteins, and sugars, also containing the mucolytic compound N-acetyl cysteine, along with antimicrobial extracts from cranberry, berberine, rosemary, and peppermint. The post-treatment biofilm mass was evaluated by crystal-violet staining, and metabolic activity was measured using the MTT assay. Average biofilm mass and metabolic activity for NEBB-treated biofilms were compared to the average of untreated control cultures. Treatment of established biofilm with NEBB resulted in biofilm-disruption, involving significant reductions in biofilm mass and metabolic activity for Candida and both Staphylococcus species. For B. burgdorferi, we observed reduced biofilm mass, but the remaining residual biofilm showed a mild increase in metabolic activity, suggesting a shift from metabolically quiescent, treatment-resistant persister forms of B. burgdorferi to a more active form, potentially more recognizable by the host immune system. For P. aeruginosa, low doses of NEBB significantly reduced biofilm mass and metabolic activity while higher doses of NEBB increased biofilm mass and metabolic activity. The results suggest that targeted nutraceutical support may help disrupt biofilm communities, offering new facets for integrative combinational treatment strategies." @default.
• W4366351444 created "2023-04-21" @default.
• W4366351444 creator A5009845784 @default.
• W4366351444 creator A5013293506 @default.
• W4366351444 creator A5027204272 @default.
• W4366351444 date "2023-03-10" @default.
• W4366351444 modified "2023-09-29" @default.
• W4366351444 title "Disruption of Established Bacterial and Fungal Biofilms by a Blend of Enzymes and Botanical Extracts" @default.
• W4366351444 cites W1206216030 @default.
• W4366351444 cites W128080686 @default.
• W4366351444 cites W1530551343 @default.
• W4366351444 cites W1543474898 @default.
• W4366351444 cites W1576277845 @default.
• W4366351444 cites W1937566680 @default.
• W4366351444 cites W1954672268 @default.
• W4366351444 cites W1964709263 @default.
• W4366351444 cites W1971932304 @default.
• W4366351444 cites W1989661679 @default.
• W4366351444 cites W1996103101 @default.
• W4366351444 cites W2007140323 @default.
• W4366351444 cites W2011596188 @default.
• W4366351444 cites W2033978225 @default.
• W4366351444 cites W2036126384 @default.
• W4366351444 cites W2052152456 @default.
• W4366351444 cites W2063405659 @default.
• W4366351444 cites W2079698171 @default.
• W4366351444 cites W2105703412 @default.
• W4366351444 cites W2123191494 @default.
• W4366351444 cites W2136310274 @default.
• W4366351444 cites W2137123557 @default.
• W4366351444 cites W2144440398 @default.
• W4366351444 cites W2145219823 @default.
• W4366351444 cites W2163463398 @default.
• W4366351444 cites W2163970869 @default.
• W4366351444 cites W2170764510 @default.
• W4366351444 cites W2214330682 @default.
• W4366351444 cites W2252911663 @default.
• W4366351444 cites W2315324126 @default.
• W4366351444 cites W2419164965 @default.
• W4366351444 cites W2462524555 @default.
• W4366351444 cites W2527743647 @default.
• W4366351444 cites W2548907591 @default.
• W4366351444 cites W2586086300 @default.
• W4366351444 cites W2600121819 @default.
• W4366351444 cites W2601920651 @default.
• W4366351444 cites W2609019415 @default.
• W4366351444 cites W2756763970 @default.
• W4366351444 cites W2756935148 @default.
• W4366351444 cites W2761783016 @default.
• W4366351444 cites W2766914417 @default.
• W4366351444 cites W2800171049 @default.
• W4366351444 cites W2807183240 @default.
• W4366351444 cites W2893806986 @default.
• W4366351444 cites W2896326261 @default.
• W4366351444 cites W2903280404 @default.
• W4366351444 cites W2944747949 @default.
• W4366351444 cites W2993487502 @default.
• W4366351444 cites W3000246374 @default.
• W4366351444 cites W3004354762 @default.
• W4366351444 cites W3008550637 @default.
• W4366351444 cites W3011178712 @default.
• W4366351444 cites W3034994749 @default.
• W4366351444 cites W3035734451 @default.
• W4366351444 cites W3036802965 @default.
• W4366351444 cites W3089328117 @default.
• W4366351444 cites W3094160313 @default.
• W4366351444 cites W3102032040 @default.
• W4366351444 cites W3123326375 @default.
• W4366351444 cites W3127508413 @default.
• W4366351444 cites W3132796409 @default.
• W4366351444 cites W3136504419 @default.
• W4366351444 cites W3155096563 @default.
• W4366351444 cites W3159610237 @default.
• W4366351444 cites W3173403511 @default.
• W4366351444 cites W3178078788 @default.
• W4366351444 cites W3178904793 @default.
• W4366351444 cites W4200341743 @default.
• W4366351444 cites W4200533375 @default.
• W4366351444 cites W4210311501 @default.
• W4366351444 cites W4211076612 @default.
• W4366351444 cites W4211108359 @default.
• W4366351444 cites W4213353716 @default.
• W4366351444 cites W4220758284 @default.
• W4366351444 cites W4281400251 @default.
• W4366351444 cites W4288041632 @default.
• W4366351444 cites W4315782831 @default.
• W4366351444 cites W52611150 @default.
• W4366351444 cites W2766538523 @default.
• W4366351444 doi "https://doi.org/10.4014/jmb.2212.12010" @default.
• W4366351444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37072676" @default.
• W4366351444 hasPublicationYear "2023" @default.
• W4366351444 type Work @default.
• W4366351444 citedByCount "0" @default.
• W4366351444 crossrefType "journal-article" @default.
• W4366351444 hasAuthorship W4366351444A5009845784 @default.
• W4366351444 hasAuthorship W4366351444A5013293506 @default.
• W4366351444 hasAuthorship W4366351444A5027204272 @default.
• W4366351444 hasBestOaLocation W43663514442 @default.

• next