SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366351661> ?p ?o ?g. }

Showing items 1 to 100 of ±153 with 100 items per page.

W4366351661 abstract "Abstract The biological roles of epithelial–mesenchymal transition (EMT) in the pathogenesis of radiation‐induced lung injury (RILI) have been widely demonstrated, but the mechanisms involved have been incompletely elucidated. N 6 ‐methyladenosine (m 6 A) modification, the most abundant reversible methylation modification in eukaryotic mRNAs, plays vital roles in multiple biological processes. Whether and how m 6 A modification participates in ionizing radiation (IR)‐induced EMT and RILI remain unclear. Here, significantly increased m 6 A levels upon IR‐induced EMT are detected both in vivo and in vitro. Furthermore, upregulated methyltransferase‐like 3 (METTL3) expression and downregulated α ‐ketoglutarate‐dependent dioxygenase AlkB homolog 5 (ALKBH5) expression are detected. In addition, blocking METTL3‐mediated m 6 A modification suppresses IR‐induced EMT both in vivo and in vitro. Mechanistically, forkhead box O1 (FOXO1) is identified as a key target of METTL3 by a methylated RNA immunoprecipitation (MeRIP) assay. FOXO1 expression is downregulated by METTL3‐mediated mRNA m 6 A modification in a YTH‐domain family 2 (YTHDF2)‐dependent manner, which subsequently activates the AKT and ERK signaling pathways. Overall, the present study shows that IR‐responsive METTL3 is involved in IR‐induced EMT, probably by activating the AKT and ERK signaling pathways via YTHDF2‐dependent FOXO1 m 6 A modification, which may be a novel mechanism involved in the occurrence and development of RILI." @default.
W4366351661 created "2023-04-21" @default.
W4366351661 creator A5004173417 @default.
W4366351661 creator A5004517509 @default.
W4366351661 creator A5009099242 @default.
W4366351661 creator A5015727229 @default.
W4366351661 creator A5020075443 @default.
W4366351661 creator A5023492006 @default.
W4366351661 creator A5024440200 @default.
W4366351661 creator A5028317592 @default.
W4366351661 creator A5055865486 @default.
W4366351661 creator A5074359554 @default.
W4366351661 creator A5084723707 @default.
W4366351661 date "2023-04-18" @default.
W4366351661 modified "2023-10-17" @default.
W4366351661 title "METTL3 Mediates Epithelial–Mesenchymal Transition by Modulating FOXO1 mRNA N<sup>6</sup>‐Methyladenosine‐Dependent YTHDF2 Binding: A Novel Mechanism of Radiation‐Induced Lung Injury" @default.
W4366351661 cites W1964847767 @default.
W4366351661 cites W1966635293 @default.
W4366351661 cites W1980325398 @default.
W4366351661 cites W1991807334 @default.
W4366351661 cites W2035843034 @default.
W4366351661 cites W2037100222 @default.
W4366351661 cites W2061722209 @default.
W4366351661 cites W2065847836 @default.
W4366351661 cites W2069075820 @default.
W4366351661 cites W2078964320 @default.
W4366351661 cites W2095534908 @default.
W4366351661 cites W2096335405 @default.
W4366351661 cites W2102278945 @default.
W4366351661 cites W2102872651 @default.
W4366351661 cites W2115038583 @default.
W4366351661 cites W2124261225 @default.
W4366351661 cites W2130974189 @default.
W4366351661 cites W2133485412 @default.
W4366351661 cites W2171808845 @default.
W4366351661 cites W2277787229 @default.
W4366351661 cites W2324098470 @default.
W4366351661 cites W2337353755 @default.
W4366351661 cites W2463708289 @default.
W4366351661 cites W2498125942 @default.
W4366351661 cites W2523076424 @default.
W4366351661 cites W2563912688 @default.
W4366351661 cites W2592240998 @default.
W4366351661 cites W2626342437 @default.
W4366351661 cites W2735092275 @default.
W4366351661 cites W2755866011 @default.
W4366351661 cites W2769400169 @default.
W4366351661 cites W2770747479 @default.
W4366351661 cites W2789490104 @default.
W4366351661 cites W2800471491 @default.
W4366351661 cites W2800678735 @default.
W4366351661 cites W2884965396 @default.
W4366351661 cites W2901322283 @default.
W4366351661 cites W2913645827 @default.
W4366351661 cites W2917695674 @default.
W4366351661 cites W2918414274 @default.
W4366351661 cites W2938870751 @default.
W4366351661 cites W2942683196 @default.
W4366351661 cites W2963951592 @default.
W4366351661 cites W2969658762 @default.
W4366351661 cites W2971661472 @default.
W4366351661 cites W2972725469 @default.
W4366351661 cites W2979436219 @default.
W4366351661 cites W2985843695 @default.
W4366351661 cites W2999740778 @default.
W4366351661 cites W3010006672 @default.
W4366351661 cites W3029046617 @default.
W4366351661 cites W3035600038 @default.
W4366351661 cites W3036255997 @default.
W4366351661 cites W3037862218 @default.
W4366351661 cites W3043123762 @default.
W4366351661 cites W3062435645 @default.
W4366351661 cites W3087655993 @default.
W4366351661 cites W3097534263 @default.
W4366351661 cites W3110909245 @default.
W4366351661 cites W3117551045 @default.
W4366351661 cites W3121051072 @default.
W4366351661 cites W3137762259 @default.
W4366351661 cites W3159494124 @default.
W4366351661 cites W3165331125 @default.
W4366351661 cites W3172002214 @default.
W4366351661 cites W3196919984 @default.
W4366351661 cites W4210645742 @default.
W4366351661 cites W4224015596 @default.
W4366351661 cites W4366351661 @default.
W4366351661 doi "https://doi.org/10.1002/advs.202204784" @default.
W4366351661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37072646" @default.
W4366351661 hasPublicationYear "2023" @default.
W4366351661 type Work @default.
W4366351661 citedByCount "1" @default.
W4366351661 countsByYear W43663516612023 @default.
W4366351661 crossrefType "journal-article" @default.
W4366351661 hasAuthorship W4366351661A5004173417 @default.
W4366351661 hasAuthorship W4366351661A5004517509 @default.
W4366351661 hasAuthorship W4366351661A5009099242 @default.
W4366351661 hasAuthorship W4366351661A5015727229 @default.
W4366351661 hasAuthorship W4366351661A5020075443 @default.
W4366351661 hasAuthorship W4366351661A5023492006 @default.
W4366351661 hasAuthorship W4366351661A5024440200 @default.
W4366351661 hasAuthorship W4366351661A5028317592 @default.