Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366351852> ?p ?o ?g. }
- W4366351852 endingPage "3496" @default.
- W4366351852 startingPage "3483" @default.
- W4366351852 abstract "Phenotypic plasticity can play an important role in the ability of animals to tolerate environmental stress, but the nature and magnitude of plastic responses are often specific to the developmental timing of exposure. Here, we examine changes in gene expression in the diaphragm of highland deer mice (Peromyscus maniculatus) in response to hypoxia exposure at different stages of development. In highland deer mice, developmental plasticity in diaphragm function may mediate changes in several respiratory traits that influence aerobic metabolism and performance under hypoxia. We generated RNAseq data from diaphragm tissue of adult deer mice exposed to (1) life-long hypoxia (before conception to adulthood), (2) post-natal hypoxia (birth to adulthood), (3) adult hypoxia (6-8 weeks only during adulthood) or (4) normoxia. We found five suites of co-regulated genes that are differentially expressed in response to hypoxia, but the patterns of differential expression depend on the developmental timing of exposure. We also identified four transcriptional modules that are associated with important respiratory traits. Many of the genes in these transcriptional modules bear signatures of altitude-related selection, providing an indirect line of evidence that observed changes in gene expression may be adaptive in hypoxic environments. Our results demonstrate the importance of developmental stage in determining the phenotypic response to environmental stressors." @default.
- W4366351852 created "2023-04-21" @default.
- W4366351852 creator A5026872382 @default.
- W4366351852 creator A5042785646 @default.
- W4366351852 creator A5047378296 @default.
- W4366351852 creator A5057615859 @default.
- W4366351852 creator A5070118734 @default.
- W4366351852 creator A5074069112 @default.
- W4366351852 date "2023-04-19" @default.
- W4366351852 modified "2023-10-17" @default.
- W4366351852 title "Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice" @default.
- W4366351852 cites W1068492584 @default.
- W4366351852 cites W1567686877 @default.
- W4366351852 cites W1864583189 @default.
- W4366351852 cites W1900781559 @default.
- W4366351852 cites W1966327575 @default.
- W4366351852 cites W1969353942 @default.
- W4366351852 cites W1983322076 @default.
- W4366351852 cites W1991880826 @default.
- W4366351852 cites W2001509111 @default.
- W4366351852 cites W2011557706 @default.
- W4366351852 cites W2043148626 @default.
- W4366351852 cites W2045828014 @default.
- W4366351852 cites W2047286003 @default.
- W4366351852 cites W2055721828 @default.
- W4366351852 cites W2057776289 @default.
- W4366351852 cites W2071653800 @default.
- W4366351852 cites W2071941077 @default.
- W4366351852 cites W2074457825 @default.
- W4366351852 cites W2078576043 @default.
- W4366351852 cites W2084284232 @default.
- W4366351852 cites W2089107511 @default.
- W4366351852 cites W2093585592 @default.
- W4366351852 cites W2098487556 @default.
- W4366351852 cites W2101465285 @default.
- W4366351852 cites W2114104545 @default.
- W4366351852 cites W2117763311 @default.
- W4366351852 cites W2123415055 @default.
- W4366351852 cites W2128699525 @default.
- W4366351852 cites W2131271579 @default.
- W4366351852 cites W2138207763 @default.
- W4366351852 cites W2147575903 @default.
- W4366351852 cites W2172078283 @default.
- W4366351852 cites W2314775476 @default.
- W4366351852 cites W2443693435 @default.
- W4366351852 cites W2541670562 @default.
- W4366351852 cites W2719752442 @default.
- W4366351852 cites W2748830422 @default.
- W4366351852 cites W2774486220 @default.
- W4366351852 cites W2896278544 @default.
- W4366351852 cites W2937384895 @default.
- W4366351852 cites W2943900631 @default.
- W4366351852 cites W2944545583 @default.
- W4366351852 cites W2946261672 @default.
- W4366351852 cites W2963518035 @default.
- W4366351852 cites W2970892914 @default.
- W4366351852 cites W2972171258 @default.
- W4366351852 cites W2988019802 @default.
- W4366351852 cites W3001602420 @default.
- W4366351852 cites W3005705246 @default.
- W4366351852 cites W3014708574 @default.
- W4366351852 cites W3027867936 @default.
- W4366351852 cites W3092476993 @default.
- W4366351852 cites W3109395447 @default.
- W4366351852 cites W3110552932 @default.
- W4366351852 cites W3111788405 @default.
- W4366351852 cites W3165482233 @default.
- W4366351852 cites W3170143789 @default.
- W4366351852 cites W3189666073 @default.
- W4366351852 cites W3208285666 @default.
- W4366351852 doi "https://doi.org/10.1111/mec.16953" @default.
- W4366351852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37073620" @default.
- W4366351852 hasPublicationYear "2023" @default.
- W4366351852 type Work @default.
- W4366351852 citedByCount "0" @default.
- W4366351852 crossrefType "journal-article" @default.
- W4366351852 hasAuthorship W4366351852A5026872382 @default.
- W4366351852 hasAuthorship W4366351852A5042785646 @default.
- W4366351852 hasAuthorship W4366351852A5047378296 @default.
- W4366351852 hasAuthorship W4366351852A5057615859 @default.
- W4366351852 hasAuthorship W4366351852A5070118734 @default.
- W4366351852 hasAuthorship W4366351852A5074069112 @default.
- W4366351852 hasBestOaLocation W43663518522 @default.
- W4366351852 hasConcept C104317684 @default.
- W4366351852 hasConcept C105702510 @default.
- W4366351852 hasConcept C121332964 @default.
- W4366351852 hasConcept C125370674 @default.
- W4366351852 hasConcept C127716648 @default.
- W4366351852 hasConcept C150194340 @default.
- W4366351852 hasConcept C162317418 @default.
- W4366351852 hasConcept C169760540 @default.
- W4366351852 hasConcept C178790620 @default.
- W4366351852 hasConcept C182215343 @default.
- W4366351852 hasConcept C185592680 @default.
- W4366351852 hasConcept C18903297 @default.
- W4366351852 hasConcept C2780157289 @default.
- W4366351852 hasConcept C2781401430 @default.
- W4366351852 hasConcept C540031477 @default.