Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366352004> ?p ?o ?g. }
- W4366352004 endingPage "720" @default.
- W4366352004 startingPage "708" @default.
- W4366352004 abstract "Autophagy plays an important role in plant antiviral defense. Several plant viruses are reported to encode viral suppressor of autophagy (VSA) to prevent autophagy for effective virus infection. However, whether and how other viruses, in particular DNA viruses, also encode VSAs to affect viral infection in plants is unknown. Here, we report that the C4 protein encoded by Cotton leaf curl Multan geminivirus (CLCuMuV) inhibits autophagy by binding to the autophagy negative regulator eukaryotic translation initiation factor 4A (eIF4A) to enhance the eIF4A-Autophagy-related protein 5 (ATG5) interaction. By contrast, the R54A or R54K mutation in C4 abolishes its capacity to interact with eIF4A, and neither C4R54A nor C4R54K can suppress autophagy. However, the R54 residue is not essential for C4 to interfere with transcriptional gene silencing or post-transcriptional gene silencing. Moreover, plants infected with mutated CLCuMuV-C4R54K develop less severe symptoms with decreased levels of viral DNA. These findings reveal a molecular mechanism underlying how the DNA virus CLCuMuV deploys a VSA to subdue host cellular antiviral autophagy defense and uphold viral infection in plants." @default.
- W4366352004 created "2023-04-21" @default.
- W4366352004 creator A5000826301 @default.
- W4366352004 creator A5013210720 @default.
- W4366352004 creator A5020457527 @default.
- W4366352004 creator A5046983645 @default.
- W4366352004 creator A5047574725 @default.
- W4366352004 creator A5059269600 @default.
- W4366352004 creator A5066986885 @default.
- W4366352004 creator A5086770052 @default.
- W4366352004 creator A5087530295 @default.
- W4366352004 creator A5088721652 @default.
- W4366352004 creator A5088824616 @default.
- W4366352004 date "2023-04-19" @default.
- W4366352004 modified "2023-10-17" @default.
- W4366352004 title "<i>Cotton Leaf Curl Multan virus</i> C4 protein suppresses autophagy to facilitate viral infection" @default.
- W4366352004 cites W1666195836 @default.
- W4366352004 cites W1973731551 @default.
- W4366352004 cites W1974787148 @default.
- W4366352004 cites W1977955723 @default.
- W4366352004 cites W2034144108 @default.
- W4366352004 cites W2037268784 @default.
- W4366352004 cites W2087563350 @default.
- W4366352004 cites W2089711178 @default.
- W4366352004 cites W2120557852 @default.
- W4366352004 cites W2130307437 @default.
- W4366352004 cites W2150249283 @default.
- W4366352004 cites W2157514051 @default.
- W4366352004 cites W2172069625 @default.
- W4366352004 cites W2344574739 @default.
- W4366352004 cites W2534638628 @default.
- W4366352004 cites W2588149486 @default.
- W4366352004 cites W2590407045 @default.
- W4366352004 cites W2592515550 @default.
- W4366352004 cites W2604396651 @default.
- W4366352004 cites W2618270695 @default.
- W4366352004 cites W2769524157 @default.
- W4366352004 cites W2774863101 @default.
- W4366352004 cites W2785077527 @default.
- W4366352004 cites W2789450022 @default.
- W4366352004 cites W2794765381 @default.
- W4366352004 cites W2805940011 @default.
- W4366352004 cites W2889451554 @default.
- W4366352004 cites W2892514092 @default.
- W4366352004 cites W2898527413 @default.
- W4366352004 cites W2911489051 @default.
- W4366352004 cites W2924243305 @default.
- W4366352004 cites W2980387609 @default.
- W4366352004 cites W2980455366 @default.
- W4366352004 cites W2981589307 @default.
- W4366352004 cites W3005869083 @default.
- W4366352004 cites W3029398702 @default.
- W4366352004 cites W3035049742 @default.
- W4366352004 cites W3047845158 @default.
- W4366352004 cites W3080579926 @default.
- W4366352004 cites W3084205505 @default.
- W4366352004 cites W3091607698 @default.
- W4366352004 cites W3108936441 @default.
- W4366352004 cites W3137470262 @default.
- W4366352004 cites W3202549510 @default.
- W4366352004 cites W3204188836 @default.
- W4366352004 cites W3211023506 @default.
- W4366352004 cites W4200014155 @default.
- W4366352004 cites W4200550798 @default.
- W4366352004 cites W4206945255 @default.
- W4366352004 cites W4223488378 @default.
- W4366352004 cites W4292181080 @default.
- W4366352004 doi "https://doi.org/10.1093/plphys/kiad235" @default.
- W4366352004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37073495" @default.
- W4366352004 hasPublicationYear "2023" @default.
- W4366352004 type Work @default.
- W4366352004 citedByCount "2" @default.
- W4366352004 countsByYear W43663520042023 @default.
- W4366352004 crossrefType "journal-article" @default.
- W4366352004 hasAuthorship W4366352004A5000826301 @default.
- W4366352004 hasAuthorship W4366352004A5013210720 @default.
- W4366352004 hasAuthorship W4366352004A5020457527 @default.
- W4366352004 hasAuthorship W4366352004A5046983645 @default.
- W4366352004 hasAuthorship W4366352004A5047574725 @default.
- W4366352004 hasAuthorship W4366352004A5059269600 @default.
- W4366352004 hasAuthorship W4366352004A5066986885 @default.
- W4366352004 hasAuthorship W4366352004A5086770052 @default.
- W4366352004 hasAuthorship W4366352004A5087530295 @default.
- W4366352004 hasAuthorship W4366352004A5088721652 @default.
- W4366352004 hasAuthorship W4366352004A5088824616 @default.
- W4366352004 hasBestOaLocation W43663520041 @default.
- W4366352004 hasConcept C104317684 @default.
- W4366352004 hasConcept C119056186 @default.
- W4366352004 hasConcept C141231307 @default.
- W4366352004 hasConcept C159047783 @default.
- W4366352004 hasConcept C166703698 @default.
- W4366352004 hasConcept C173396325 @default.
- W4366352004 hasConcept C190283241 @default.
- W4366352004 hasConcept C203522944 @default.
- W4366352004 hasConcept C2191507 @default.
- W4366352004 hasConcept C2522874641 @default.
- W4366352004 hasConcept C25602115 @default.
- W4366352004 hasConcept C2779758228 @default.