Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366352738> ?p ?o ?g. }
- W4366352738 abstract "CD8+ T cell recognition of Mycobacterium tuberculosis (Mtb)-specific peptides presented on major histocompatibility complex class I (MHC-I) contributes to immunity to tuberculosis (TB), but the principles that govern presentation of Mtb antigens on MHC-I are incompletely understood. In this study, mass spectrometry (MS) analysis of the MHC-I repertoire of Mtb-infected primary human macrophages reveals that substrates of Mtb's type VII secretion systems (T7SS) are overrepresented among Mtb-derived peptides presented on MHC-I. Quantitative, targeted MS shows that ESX-1 activity is required for presentation of Mtb peptides derived from both ESX-1 substrates and ESX-5 substrates on MHC-I, consistent with a model in which proteins secreted by multiple T7SSs access a cytosolic antigen processing pathway via ESX-1-mediated phagosome permeabilization. Chemical inhibition of proteasome activity, lysosomal acidification, or cysteine cathepsin activity did not block presentation of Mtb antigens on MHC-I, suggesting involvement of other proteolytic pathways or redundancy among multiple pathways. Our study identifies Mtb antigens presented on MHC-I that could serve as targets for TB vaccines, and reveals how the activity of multiple T7SSs interacts to contribute to presentation of Mtb antigens on MHC-I." @default.
- W4366352738 created "2023-04-21" @default.
- W4366352738 creator A5032078195 @default.
- W4366352738 creator A5063430862 @default.
- W4366352738 creator A5076061881 @default.
- W4366352738 date "2023-04-19" @default.
- W4366352738 modified "2023-10-18" @default.
- W4366352738 title "Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I" @default.
- W4366352738 cites W1485263312 @default.
- W4366352738 cites W1542682521 @default.
- W4366352738 cites W1553697637 @default.
- W4366352738 cites W1662338722 @default.
- W4366352738 cites W1908004152 @default.
- W4366352738 cites W1920434477 @default.
- W4366352738 cites W1940294549 @default.
- W4366352738 cites W1974012392 @default.
- W4366352738 cites W1985004048 @default.
- W4366352738 cites W1993796017 @default.
- W4366352738 cites W1998755383 @default.
- W4366352738 cites W2006252982 @default.
- W4366352738 cites W2018937143 @default.
- W4366352738 cites W2023234633 @default.
- W4366352738 cites W2023774776 @default.
- W4366352738 cites W2023874344 @default.
- W4366352738 cites W2025250293 @default.
- W4366352738 cites W2028920074 @default.
- W4366352738 cites W2029904937 @default.
- W4366352738 cites W2033232488 @default.
- W4366352738 cites W2035256770 @default.
- W4366352738 cites W2040558306 @default.
- W4366352738 cites W2040650178 @default.
- W4366352738 cites W2045080821 @default.
- W4366352738 cites W2051792510 @default.
- W4366352738 cites W2056748088 @default.
- W4366352738 cites W2056975050 @default.
- W4366352738 cites W2057740405 @default.
- W4366352738 cites W2068051174 @default.
- W4366352738 cites W2076539366 @default.
- W4366352738 cites W2077530579 @default.
- W4366352738 cites W2089114270 @default.
- W4366352738 cites W2089777523 @default.
- W4366352738 cites W2097481253 @default.
- W4366352738 cites W2102692786 @default.
- W4366352738 cites W2104612877 @default.
- W4366352738 cites W2104847655 @default.
- W4366352738 cites W2106195012 @default.
- W4366352738 cites W2106942635 @default.
- W4366352738 cites W2110132503 @default.
- W4366352738 cites W2116206670 @default.
- W4366352738 cites W2116619718 @default.
- W4366352738 cites W2117736684 @default.
- W4366352738 cites W2121449107 @default.
- W4366352738 cites W2123036801 @default.
- W4366352738 cites W2130206397 @default.
- W4366352738 cites W2130906551 @default.
- W4366352738 cites W2131715198 @default.
- W4366352738 cites W2141681443 @default.
- W4366352738 cites W2148274459 @default.
- W4366352738 cites W2157559696 @default.
- W4366352738 cites W2158035277 @default.
- W4366352738 cites W2161842856 @default.
- W4366352738 cites W2162596168 @default.
- W4366352738 cites W2225338927 @default.
- W4366352738 cites W2283857467 @default.
- W4366352738 cites W2345284488 @default.
- W4366352738 cites W2405978957 @default.
- W4366352738 cites W2525950393 @default.
- W4366352738 cites W2556833369 @default.
- W4366352738 cites W2580358075 @default.
- W4366352738 cites W2603447764 @default.
- W4366352738 cites W2605830019 @default.
- W4366352738 cites W2615239704 @default.
- W4366352738 cites W2748060490 @default.
- W4366352738 cites W2793859699 @default.
- W4366352738 cites W2801827592 @default.
- W4366352738 cites W2902814816 @default.
- W4366352738 cites W2952724804 @default.
- W4366352738 cites W2996703088 @default.
- W4366352738 cites W3010069454 @default.
- W4366352738 cites W3022647289 @default.
- W4366352738 cites W3024570138 @default.
- W4366352738 cites W3031716951 @default.
- W4366352738 cites W3125681153 @default.
- W4366352738 cites W3133923741 @default.
- W4366352738 cites W3173082674 @default.
- W4366352738 cites W3196945974 @default.
- W4366352738 cites W3208691473 @default.
- W4366352738 cites W334851005 @default.
- W4366352738 cites W4206950245 @default.
- W4366352738 cites W4223551334 @default.
- W4366352738 cites W4281781469 @default.
- W4366352738 cites W4281992815 @default.
- W4366352738 cites W4308658038 @default.
- W4366352738 cites W4310089599 @default.
- W4366352738 doi "https://doi.org/10.7554/elife.84070" @default.
- W4366352738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37073954" @default.
- W4366352738 hasPublicationYear "2023" @default.
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