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- W4366352806 abstract "The transport of transition metal ions by members of the SLC11/NRAMP family constitutes a ubiquitous mechanism for the uptake of Fe 2+ and Mn 2+ across all kingdoms of life. Despite the strong conservation of the family, two of its branches have evolved a distinct substrate preference with one mediating Mg 2+ uptake in prokaryotes and another the transport of Al 3+ into plant cells. Our previous work on the SLC11 transporter from Eggerthella lenta revealed the basis for its Mg 2+ selectivity (Ramanadane et al., 2022). Here, we have addressed the structural and functional properties of a putative Al 3+ transporter from Setaria italica . We show that the protein transports diverse divalent metal ions and binds the trivalent ions Al 3+ and Ga 3+ , which are both presumable substrates. Its cryo-electron microscopy (cryo-EM) structure displays an occluded conformation that is closer to an inward- than an outward-facing state, with a binding site that is remodeled to accommodate the increased charge density of its transported substrate." @default.
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- W4366352806 date "2023-04-19" @default.
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- W4366352806 title "Structural and functional properties of a plant NRAMP-related aluminum transporter" @default.
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- W4366352806 doi "https://doi.org/10.7554/elife.85641" @default.
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