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- W4366352810 abstract "The occurrence of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) has been reported since the coronavirus disease 2019 (COVID-19) vaccination, but whether there is a causal relationship or coincidence remains to be verified. We combined the term COVID-19 vaccination with each word of AAV to search for case reports and case series published in PubMed, EMBASE, and Web of Science databases before 13 March 2023. A total of 56 patients who developed AAV after COVID-19 vaccination were identified from 44 research centers. Of the 56 subjects, 43 (76.7%) were vaccinated with the mRNA vaccine, followed by the adenovirus vaccine (14.3%) and inactivated vaccine (9.0%) (P = 0.015). Compared with relapsed AAV, new-onset AAV patients had at least two other diseases previously (P < 0.001). Twenty-five (44.6%) patients presented symptoms after the first injection, and the medium onset time was 12 (1-77) days, while Twenty-eight (50.0%) patients developed symptoms after the second dose, and their medium period was 14 (1-60) days. Forty-four (78.5%) patients achieved remission after immunosuppressive agents, plasma exchange, and hemodialysis. One (1.8%) patient died from progressive respiratory failure and nine (16.1%) did not recover, leaving five patients permanently dependent on hemodialysis. Pathogenic ANCA may be activated by enhanced immune response and epitope spreading after COVID-19 vaccination and induced the occurrence of AAV, especially in genetically susceptible populations." @default.
- W4366352810 created "2023-04-21" @default.
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- W4366352810 date "2023-04-19" @default.
- W4366352810 modified "2023-10-15" @default.
- W4366352810 title "New insights of antineutrophil cytoplasmic antibody-associated vasculitis from the perspective of COVID-19 vaccination" @default.
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- W4366352810 doi "https://doi.org/10.1093/cei/uxad043" @default.
- W4366352810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37074008" @default.
- W4366352810 hasPublicationYear "2023" @default.
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