Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366365526> ?p ?o ?g. }
- W4366365526 abstract "Abstract Photothermal immunotherapy, the combination of photothermal hyperthermia and immunotherapy, is a noninvasive and desirable therapeutic strategy to address the deficiency of traditional photothermal ablation for tumor treatment. However, insufficient T‐cell activation following photothermal treatment is a bottleneck to achieve satisfactory therapeutic effectiveness. In this work, a multifunctional nanoplatform is rationally designed and engineered on the basis of polypyrrole‐based magnetic nanomedicine modified by T‐cell activators of anti‐CD3 and anti‐CD28 monoclonal antibodies, which have achieved robust near infrared laser‐triggered photothermal ablation and long‐lasting T‐cell activation, realizing diagnostic imaging‐guided immunosuppressive tumor microenvironment regulation following photothermal hyperthermia by reinvigorating tumor‐infiltrating lymphocytes. By virtue of high‐efficient immunogenic cell death and dendritic cell maturation combined with T‐cell activation, this nanosystem markedly restrains primary and abscopal tumors as well as metastatic tumors with negligible side effects in vivo, exerting the specific function for suppressing tumor recurrence and metastasis by establishing a long‐term memory immune response." @default.
- W4366365526 created "2023-04-21" @default.
- W4366365526 creator A5040425226 @default.
- W4366365526 creator A5052225808 @default.
- W4366365526 creator A5055849155 @default.
- W4366365526 creator A5071615431 @default.
- W4366365526 creator A5074509186 @default.
- W4366365526 creator A5075247746 @default.
- W4366365526 creator A5077169247 @default.
- W4366365526 creator A5088430120 @default.
- W4366365526 creator A5035910544 @default.
- W4366365526 date "2023-04-19" @default.
- W4366365526 modified "2023-10-15" @default.
- W4366365526 title "Photonic Hyperthermia Synergizes with Immune‐Activators to Augment Tumor‐Localized Immunotherapy" @default.
- W4366365526 cites W1583432150 @default.
- W4366365526 cites W1981480494 @default.
- W4366365526 cites W1992384164 @default.
- W4366365526 cites W1992950391 @default.
- W4366365526 cites W1996608695 @default.
- W4366365526 cites W1997843836 @default.
- W4366365526 cites W1998844140 @default.
- W4366365526 cites W2055942373 @default.
- W4366365526 cites W2095554214 @default.
- W4366365526 cites W2115726554 @default.
- W4366365526 cites W2144908002 @default.
- W4366365526 cites W2159694425 @default.
- W4366365526 cites W2292286849 @default.
- W4366365526 cites W2333975681 @default.
- W4366365526 cites W2772063315 @default.
- W4366365526 cites W2774214122 @default.
- W4366365526 cites W2791655169 @default.
- W4366365526 cites W2799307831 @default.
- W4366365526 cites W2889140301 @default.
- W4366365526 cites W2890587360 @default.
- W4366365526 cites W2905252880 @default.
- W4366365526 cites W2913970879 @default.
- W4366365526 cites W2942900492 @default.
- W4366365526 cites W2951186801 @default.
- W4366365526 cites W2970536272 @default.
- W4366365526 cites W2976327711 @default.
- W4366365526 cites W2991257559 @default.
- W4366365526 cites W2998673845 @default.
- W4366365526 cites W3012159221 @default.
- W4366365526 cites W3039693333 @default.
- W4366365526 cites W3041040828 @default.
- W4366365526 cites W3163204015 @default.
- W4366365526 cites W4282833163 @default.
- W4366365526 cites W4310078338 @default.
- W4366365526 cites W4313423580 @default.
- W4366365526 doi "https://doi.org/10.1002/smtd.202300116" @default.
- W4366365526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37075769" @default.
- W4366365526 hasPublicationYear "2023" @default.
- W4366365526 type Work @default.
- W4366365526 citedByCount "1" @default.
- W4366365526 crossrefType "journal-article" @default.
- W4366365526 hasAuthorship W4366365526A5035910544 @default.
- W4366365526 hasAuthorship W4366365526A5040425226 @default.
- W4366365526 hasAuthorship W4366365526A5052225808 @default.
- W4366365526 hasAuthorship W4366365526A5055849155 @default.
- W4366365526 hasAuthorship W4366365526A5071615431 @default.
- W4366365526 hasAuthorship W4366365526A5074509186 @default.
- W4366365526 hasAuthorship W4366365526A5075247746 @default.
- W4366365526 hasAuthorship W4366365526A5077169247 @default.
- W4366365526 hasAuthorship W4366365526A5088430120 @default.
- W4366365526 hasConcept C126322002 @default.
- W4366365526 hasConcept C171250308 @default.
- W4366365526 hasConcept C182606246 @default.
- W4366365526 hasConcept C192562407 @default.
- W4366365526 hasConcept C203014093 @default.
- W4366365526 hasConcept C2776090121 @default.
- W4366365526 hasConcept C2776107976 @default.
- W4366365526 hasConcept C2777701055 @default.
- W4366365526 hasConcept C2777877232 @default.
- W4366365526 hasConcept C2779949491 @default.
- W4366365526 hasConcept C502942594 @default.
- W4366365526 hasConcept C71924100 @default.
- W4366365526 hasConcept C8891405 @default.
- W4366365526 hasConceptScore W4366365526C126322002 @default.
- W4366365526 hasConceptScore W4366365526C171250308 @default.
- W4366365526 hasConceptScore W4366365526C182606246 @default.
- W4366365526 hasConceptScore W4366365526C192562407 @default.
- W4366365526 hasConceptScore W4366365526C203014093 @default.
- W4366365526 hasConceptScore W4366365526C2776090121 @default.
- W4366365526 hasConceptScore W4366365526C2776107976 @default.
- W4366365526 hasConceptScore W4366365526C2777701055 @default.
- W4366365526 hasConceptScore W4366365526C2777877232 @default.
- W4366365526 hasConceptScore W4366365526C2779949491 @default.
- W4366365526 hasConceptScore W4366365526C502942594 @default.
- W4366365526 hasConceptScore W4366365526C71924100 @default.
- W4366365526 hasConceptScore W4366365526C8891405 @default.
- W4366365526 hasFunder F4320321001 @default.
- W4366365526 hasFunder F4320336620 @default.
- W4366365526 hasIssue "5" @default.
- W4366365526 hasLocation W43663655261 @default.
- W4366365526 hasLocation W43663655262 @default.
- W4366365526 hasOpenAccess W4366365526 @default.
- W4366365526 hasPrimaryLocation W43663655261 @default.
- W4366365526 hasRelatedWork W2073541380 @default.
- W4366365526 hasRelatedWork W2898379310 @default.
- W4366365526 hasRelatedWork W2938706471 @default.