Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366367910> ?p ?o ?g. }
- W4366367910 abstract "Nucleotide-binding domain and leucine rich repeat family pyrin domain containing 3 (NLRP3) inflammasomes are implicated in diverse inflammatory diseases, so their activation needs to be tightly controlled. Over generation of reactive oxygen species (ROS) is a key factor in NLRP3 inflammasome activation. Consequently, nanozymes with ROS scavenging ability are potential inhibitors of NLRP3 activation and promising therapeutic agents for related inflammatory diseases. Herein, a type of 2D cobalt hydroxide oxide nanosheets (Co NSs), a nanozyme with excellent multienzyme-like activity, possessing peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activities, exhibits superior ROS scavenging properties and protects cells from oxidative damage. Density functional theory (DFT) calculations further reveal these enzyme-like catalytic reactions of ROS eliminating are spontaneous and CAT is dominant under physiological conditions. Performing multienzyme properties, Co NSs present excellent anti-inflammation activity by blocking NLRP3 oligomerization and ASC speck formation, thereby inhibiting NLRP3 inflammasome assembly and activation. Importantly, treatment with Co NSs attenuates the severity of LPS-induced systemic inflammation and DSS-induced colitis. This study highlights a successful strategy for utilizing cobalt-based nanozymes to scavenge ROS and provides valuable insights into the underlying mechanism, demonstrating the potential therapeutic effects of nanozyme for the prevention and treatment of NLRP3-associatied inflammatory diseases." @default.
- W4366367910 created "2023-04-21" @default.
- W4366367910 creator A5005509338 @default.
- W4366367910 creator A5007658109 @default.
- W4366367910 creator A5019825145 @default.
- W4366367910 creator A5021166192 @default.
- W4366367910 creator A5034484688 @default.
- W4366367910 creator A5047223239 @default.
- W4366367910 creator A5049341927 @default.
- W4366367910 creator A5057828117 @default.
- W4366367910 creator A5085176870 @default.
- W4366367910 creator A5087586114 @default.
- W4366367910 date "2023-04-19" @default.
- W4366367910 modified "2023-10-14" @default.
- W4366367910 title "2D Cobalt Oxyhydroxide Nanozymes Inhibit Inflammation by Targeting the NLRP3 Inflammasome" @default.
- W4366367910 cites W1561041814 @default.
- W4366367910 cites W1822745879 @default.
- W4366367910 cites W1905358342 @default.
- W4366367910 cites W1925052883 @default.
- W4366367910 cites W2009435405 @default.
- W4366367910 cites W2016281184 @default.
- W4366367910 cites W2029871153 @default.
- W4366367910 cites W2030023942 @default.
- W4366367910 cites W2050449334 @default.
- W4366367910 cites W2084158898 @default.
- W4366367910 cites W2088254488 @default.
- W4366367910 cites W2115252398 @default.
- W4366367910 cites W2126983544 @default.
- W4366367910 cites W2128190429 @default.
- W4366367910 cites W2145001648 @default.
- W4366367910 cites W2165291607 @default.
- W4366367910 cites W2166209782 @default.
- W4366367910 cites W2232192360 @default.
- W4366367910 cites W2255766754 @default.
- W4366367910 cites W2296523452 @default.
- W4366367910 cites W2339575065 @default.
- W4366367910 cites W2406575179 @default.
- W4366367910 cites W2550440327 @default.
- W4366367910 cites W2558664210 @default.
- W4366367910 cites W2596006789 @default.
- W4366367910 cites W2604756124 @default.
- W4366367910 cites W2608687752 @default.
- W4366367910 cites W2735527928 @default.
- W4366367910 cites W2736346397 @default.
- W4366367910 cites W2786474781 @default.
- W4366367910 cites W2789997601 @default.
- W4366367910 cites W2806573774 @default.
- W4366367910 cites W2887163385 @default.
- W4366367910 cites W2898114337 @default.
- W4366367910 cites W2905296697 @default.
- W4366367910 cites W2915214302 @default.
- W4366367910 cites W2918169297 @default.
- W4366367910 cites W2923350517 @default.
- W4366367910 cites W2943293743 @default.
- W4366367910 cites W2945928565 @default.
- W4366367910 cites W2954569873 @default.
- W4366367910 cites W2954782052 @default.
- W4366367910 cites W2955074241 @default.
- W4366367910 cites W2971095732 @default.
- W4366367910 cites W2971280984 @default.
- W4366367910 cites W2972338204 @default.
- W4366367910 cites W2982045176 @default.
- W4366367910 cites W2997253707 @default.
- W4366367910 cites W3005110988 @default.
- W4366367910 cites W3020246886 @default.
- W4366367910 cites W3023764799 @default.
- W4366367910 cites W3028618163 @default.
- W4366367910 cites W3043481359 @default.
- W4366367910 cites W3090358236 @default.
- W4366367910 cites W3094590694 @default.
- W4366367910 cites W3097930029 @default.
- W4366367910 cites W3110102449 @default.
- W4366367910 cites W3113078272 @default.
- W4366367910 cites W3120248152 @default.
- W4366367910 cites W3123454073 @default.
- W4366367910 cites W3135708842 @default.
- W4366367910 cites W3139332184 @default.
- W4366367910 cites W3156145557 @default.
- W4366367910 cites W3195548726 @default.
- W4366367910 cites W3197159314 @default.
- W4366367910 cites W3200394304 @default.
- W4366367910 cites W3203235953 @default.
- W4366367910 cites W4210527197 @default.
- W4366367910 cites W4210970969 @default.
- W4366367910 cites W4211164755 @default.
- W4366367910 cites W4211217520 @default.
- W4366367910 cites W4283692305 @default.
- W4366367910 cites W4290888478 @default.
- W4366367910 cites W4376849343 @default.
- W4366367910 cites W602304908 @default.
- W4366367910 doi "https://doi.org/10.1002/adfm.202214693" @default.
- W4366367910 hasPublicationYear "2023" @default.
- W4366367910 type Work @default.
- W4366367910 citedByCount "2" @default.
- W4366367910 countsByYear W43663679102023 @default.
- W4366367910 crossrefType "journal-article" @default.
- W4366367910 hasAuthorship W4366367910A5005509338 @default.
- W4366367910 hasAuthorship W4366367910A5007658109 @default.
- W4366367910 hasAuthorship W4366367910A5019825145 @default.
- W4366367910 hasAuthorship W4366367910A5021166192 @default.