Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366368392> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4366368392 endingPage "186" @default.
- W4366368392 startingPage "180" @default.
- W4366368392 abstract "Abstract Chitin is a highly abundant N-acetylglucosamine polysaccharide that has been linked to immune responses in the context of fungal infections and allergic asthma, especially to T helper 2 immune responses. Unfortunately, due to the frequent use of crude chitin preparations of unknown purity and degree of polymerization, there is still great uncertainty about how chitin activates different parts of the human immune system. We recently identified chitin oligomers of 6 N-acetylglucosamine units as the smallest immunologically active chitin motif and the innate immune receptor TLR2 as a primary chitin sensor on human and murine myeloid cells, but the response of further immune cells (e.g. lymphoid cells) to oligomeric chitin has not been investigated. Our analysis of primary human immune cells now shows that chitin oligomers activate immune responses of both innate and adaptive lymphocytes: notably, chitin oligomers activated natural killer cells but not B lymphocytes. Moreover, chitin oligomers induced maturation of dendritic cells and enabled potent CD8+ T-cell recall responses. Our results suggest that chitin oligomers not only trigger immediate innate responses in a limited range of myeloid cells but also exert critical activities across the entire human immune system. This highlights chitin oligomer immune activation as an interesting and broadly applicable potential target for both adjuvant development and therapeutic interference in chitin-mediated pathologies." @default.
- W4366368392 created "2023-04-21" @default.
- W4366368392 creator A5003613132 @default.
- W4366368392 creator A5013341298 @default.
- W4366368392 creator A5025281782 @default.
- W4366368392 creator A5027231761 @default.
- W4366368392 creator A5034428036 @default.
- W4366368392 creator A5037039372 @default.
- W4366368392 creator A5040507303 @default.
- W4366368392 creator A5066068373 @default.
- W4366368392 creator A5071617604 @default.
- W4366368392 creator A5073964958 @default.
- W4366368392 date "2023-04-19" @default.
- W4366368392 modified "2023-09-25" @default.
- W4366368392 title "Chitin oligomers promote lymphoid innate and adaptive immune cell activation" @default.
- W4366368392 cites W1963741247 @default.
- W4366368392 cites W2004659460 @default.
- W4366368392 cites W2031643800 @default.
- W4366368392 cites W2035662671 @default.
- W4366368392 cites W2093683696 @default.
- W4366368392 cites W2093818323 @default.
- W4366368392 cites W2100604737 @default.
- W4366368392 cites W2105810938 @default.
- W4366368392 cites W2107794472 @default.
- W4366368392 cites W2123431656 @default.
- W4366368392 cites W2146859436 @default.
- W4366368392 cites W2153034426 @default.
- W4366368392 cites W2343094138 @default.
- W4366368392 cites W2415527696 @default.
- W4366368392 cites W2524345511 @default.
- W4366368392 cites W2606047052 @default.
- W4366368392 cites W2897131885 @default.
- W4366368392 cites W3137566438 @default.
- W4366368392 cites W3186999055 @default.
- W4366368392 cites W3215049942 @default.
- W4366368392 doi "https://doi.org/10.1093/jleuko/qiad044" @default.
- W4366368392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37075217" @default.
- W4366368392 hasPublicationYear "2023" @default.
- W4366368392 type Work @default.
- W4366368392 citedByCount "0" @default.
- W4366368392 crossrefType "journal-article" @default.
- W4366368392 hasAuthorship W4366368392A5003613132 @default.
- W4366368392 hasAuthorship W4366368392A5013341298 @default.
- W4366368392 hasAuthorship W4366368392A5025281782 @default.
- W4366368392 hasAuthorship W4366368392A5027231761 @default.
- W4366368392 hasAuthorship W4366368392A5034428036 @default.
- W4366368392 hasAuthorship W4366368392A5037039372 @default.
- W4366368392 hasAuthorship W4366368392A5040507303 @default.
- W4366368392 hasAuthorship W4366368392A5066068373 @default.
- W4366368392 hasAuthorship W4366368392A5071617604 @default.
- W4366368392 hasAuthorship W4366368392A5073964958 @default.
- W4366368392 hasConcept C136449434 @default.
- W4366368392 hasConcept C157081693 @default.
- W4366368392 hasConcept C193419808 @default.
- W4366368392 hasConcept C203014093 @default.
- W4366368392 hasConcept C2779732960 @default.
- W4366368392 hasConcept C2781088250 @default.
- W4366368392 hasConcept C47742525 @default.
- W4366368392 hasConcept C55493867 @default.
- W4366368392 hasConcept C86803240 @default.
- W4366368392 hasConcept C8891405 @default.
- W4366368392 hasConcept C95444343 @default.
- W4366368392 hasConceptScore W4366368392C136449434 @default.
- W4366368392 hasConceptScore W4366368392C157081693 @default.
- W4366368392 hasConceptScore W4366368392C193419808 @default.
- W4366368392 hasConceptScore W4366368392C203014093 @default.
- W4366368392 hasConceptScore W4366368392C2779732960 @default.
- W4366368392 hasConceptScore W4366368392C2781088250 @default.
- W4366368392 hasConceptScore W4366368392C47742525 @default.
- W4366368392 hasConceptScore W4366368392C55493867 @default.
- W4366368392 hasConceptScore W4366368392C86803240 @default.
- W4366368392 hasConceptScore W4366368392C8891405 @default.
- W4366368392 hasConceptScore W4366368392C95444343 @default.
- W4366368392 hasIssue "2" @default.
- W4366368392 hasLocation W43663683921 @default.
- W4366368392 hasLocation W43663683922 @default.
- W4366368392 hasOpenAccess W4366368392 @default.
- W4366368392 hasPrimaryLocation W43663683921 @default.
- W4366368392 hasRelatedWork W1993026721 @default.
- W4366368392 hasRelatedWork W2086739630 @default.
- W4366368392 hasRelatedWork W2135436588 @default.
- W4366368392 hasRelatedWork W2141330728 @default.
- W4366368392 hasRelatedWork W2267446069 @default.
- W4366368392 hasRelatedWork W2502627433 @default.
- W4366368392 hasRelatedWork W2601654563 @default.
- W4366368392 hasRelatedWork W2980409591 @default.
- W4366368392 hasRelatedWork W4281729072 @default.
- W4366368392 hasRelatedWork W4312305738 @default.
- W4366368392 hasVolume "114" @default.
- W4366368392 isParatext "false" @default.
- W4366368392 isRetracted "false" @default.
- W4366368392 workType "article" @default.