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• W4366368422 abstract "Many RNA delivery strategies require efficient endosomal uptake and release. To monitor this process, we developed a 2′-OMe RNA-based ratiometric pH probe with a pH-invariant 3′-Cy5 and 5′-FAM whose pH sensitivity is enhanced by proximal guanines. The probe, in duplex with a DNA complement, exhibits a 48.9-fold FAM fluorescence enhancement going from pH 4.5 to pH 8.0 and reports on both endosomal entrapment and release when delivered to HeLa cells. In complex with an antisense RNA complement, the probe constitutes an siRNA mimic capable of protein knockdown in HEK293T cells. This illustrates a general approach for measuring the localization and pH microenvironment of any oligonucleotide." @default.
• W4366368422 created "2023-04-21" @default.
• W4366368422 creator A5062574852 @default.
• W4366368422 creator A5069032140 @default.
• W4366368422 date "2023-04-19" @default.
• W4366368422 modified "2023-10-18" @default.
• W4366368422 title "Ratiometric, pH-Sensitive Probe for Monitoring siRNA Delivery" @default.
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• W4366368422 doi "https://doi.org/10.1021/jacs.3c01032" @default.
• W4366368422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37075200" @default.
• W4366368422 hasPublicationYear "2023" @default.
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