FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366371546> ?p ?o ?g. }

• W4366371546 abstract "Impaired ventricular relaxation influences left ventricular pressures during exercise in heart failure with preserved ejection fraction (HFpEF). Sarco/endoplasmic reticulum calcium-adenosine triphosphatase (SERCA2a) facilitates myocardial relaxation by increasing calcium reuptake and is impaired in HFpEF.This study sought to investigate the effects of istaroxime, a SERCA2 agonist, on lusitropic and hemodynamic function during exercise in patients with HFpEF and control subjects.Eleven control subjects (7 male, 4 female) and 15 patients with HFpEF (8 male, 7 female) performed upright cycle exercise with right-sided heart catheterization. Participants received istaroxime (0.5 μg/kg/min) or saline placebo (single-blind, crossover design). Cardiac output, pulmonary capillary wedge pressure (PCWP), and diastolic function were measured at rest and during submaximal exercise. In an exploratory analysis (Hedge's g), 7 patients with HFpEF received higher-dose istaroxime (1.0 μg/kg/min). End-systolic elastance (Ees) was calculated by dividing systolic blood pressure (SBP) × 0.9 by end-systolic volume (ESV) (on 3-dimensional echocardiography).Patients with HFpEF had higher PCWP (25 ± 10 mm Hg vs 12 ± 5 mm Hg; P < 0.001) and lower tissue Doppler velocities during exercise. Istaroxime (0.5 μg/kg/min) had no effect on resting or exercise measures in patients with HFpEF or control subjects. Control subjects had a larger increase in Ees (Δ 1.55 ± 0.99 mm Hg/mL vs Δ 0.86 ± 1.31 mm Hg/mL; P = 0.03), driven by lower ESV. Comparing placebo and istaroxime 1.0 μg/kg/min during exercise, PCWP during the 1.0 μg/kg/min istaroxime dose was slightly lower (Δ 2.2 mm Hg; Hedge's g = 0.30). There were no effects on diastolic function, but there were increases in SBP and s', suggesting a mild inotropic effect.Low-dose istaroxime had no effect on cardiac filling pressure or parameters of relaxation in patients with HFpEF during exercise. Higher doses of istaroxime may have been more effective in reducing exercise PCWP in patients with HFpEF. (Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a; NCT02772068)." @default.
• W4366371546 created "2023-04-21" @default.
• W4366371546 creator A5001795323 @default.
• W4366371546 creator A5002218685 @default.
• W4366371546 creator A5022787593 @default.
• W4366371546 creator A5029108683 @default.
• W4366371546 creator A5036851202 @default.
• W4366371546 creator A5062594035 @default.
• W4366371546 creator A5064877927 @default.
• W4366371546 creator A5083634437 @default.
• W4366371546 date "2023-04-01" @default.
• W4366371546 modified "2023-10-14" @default.
• W4366371546 title "SERCA2a Agonist Effects on Cardiac Performance During Exercise in Heart Failure With Preserved Ejection Fraction" @default.
• W4366371546 cites W171959177 @default.
• W4366371546 cites W1992427742 @default.
• W4366371546 cites W2010510526 @default.
• W4366371546 cites W2013798426 @default.
• W4366371546 cites W2051315781 @default.
• W4366371546 cites W2055483222 @default.
• W4366371546 cites W2092557231 @default.
• W4366371546 cites W2102688445 @default.
• W4366371546 cites W2116177557 @default.
• W4366371546 cites W2123490348 @default.
• W4366371546 cites W2130679502 @default.
• W4366371546 cites W2159453909 @default.
• W4366371546 cites W2162693762 @default.
• W4366371546 cites W2311933573 @default.
• W4366371546 cites W2313186535 @default.
• W4366371546 cites W2476146068 @default.
• W4366371546 cites W2605728656 @default.
• W4366371546 cites W2610625640 @default.
• W4366371546 cites W3001727981 @default.
• W4366371546 cites W3011986409 @default.
• W4366371546 cites W3123807922 @default.
• W4366371546 cites W98344349 @default.
• W4366371546 doi "https://doi.org/10.1016/j.jchf.2023.02.006" @default.
• W4366371546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37086245" @default.
• W4366371546 hasPublicationYear "2023" @default.
• W4366371546 type Work @default.
• W4366371546 citedByCount "2" @default.
• W4366371546 countsByYear W43663715462023 @default.
• W4366371546 crossrefType "journal-article" @default.
• W4366371546 hasAuthorship W4366371546A5001795323 @default.
• W4366371546 hasAuthorship W4366371546A5002218685 @default.
• W4366371546 hasAuthorship W4366371546A5022787593 @default.
• W4366371546 hasAuthorship W4366371546A5029108683 @default.
• W4366371546 hasAuthorship W4366371546A5036851202 @default.
• W4366371546 hasAuthorship W4366371546A5062594035 @default.
• W4366371546 hasAuthorship W4366371546A5064877927 @default.
• W4366371546 hasAuthorship W4366371546A5083634437 @default.
• W4366371546 hasConcept C126322002 @default.
• W4366371546 hasConcept C146556889 @default.
• W4366371546 hasConcept C164705383 @default.
• W4366371546 hasConcept C178853913 @default.
• W4366371546 hasConcept C2777099384 @default.
• W4366371546 hasConcept C2777953023 @default.
• W4366371546 hasConcept C2778198053 @default.
• W4366371546 hasConcept C2781185063 @default.
• W4366371546 hasConcept C57900726 @default.
• W4366371546 hasConcept C68923441 @default.
• W4366371546 hasConcept C71924100 @default.
• W4366371546 hasConcept C78085059 @default.
• W4366371546 hasConcept C80461066 @default.
• W4366371546 hasConcept C84393581 @default.
• W4366371546 hasConceptScore W4366371546C126322002 @default.
• W4366371546 hasConceptScore W4366371546C146556889 @default.
• W4366371546 hasConceptScore W4366371546C164705383 @default.
• W4366371546 hasConceptScore W4366371546C178853913 @default.
• W4366371546 hasConceptScore W4366371546C2777099384 @default.
• W4366371546 hasConceptScore W4366371546C2777953023 @default.
• W4366371546 hasConceptScore W4366371546C2778198053 @default.
• W4366371546 hasConceptScore W4366371546C2781185063 @default.
• W4366371546 hasConceptScore W4366371546C57900726 @default.
• W4366371546 hasConceptScore W4366371546C68923441 @default.
• W4366371546 hasConceptScore W4366371546C71924100 @default.
• W4366371546 hasConceptScore W4366371546C78085059 @default.
• W4366371546 hasConceptScore W4366371546C80461066 @default.
• W4366371546 hasConceptScore W4366371546C84393581 @default.
• W4366371546 hasFunder F4320332161 @default.
• W4366371546 hasLocation W43663715461 @default.
• W4366371546 hasLocation W43663715462 @default.
• W4366371546 hasOpenAccess W4366371546 @default.
• W4366371546 hasPrimaryLocation W43663715461 @default.
• W4366371546 hasRelatedWork W1964205598 @default.
• W4366371546 hasRelatedWork W2061321770 @default.
• W4366371546 hasRelatedWork W2102688445 @default.
• W4366371546 hasRelatedWork W2316342240 @default.
• W4366371546 hasRelatedWork W2475222081 @default.
• W4366371546 hasRelatedWork W2789205885 @default.
• W4366371546 hasRelatedWork W2965474825 @default.
• W4366371546 hasRelatedWork W3033076790 @default.
• W4366371546 hasRelatedWork W4200030969 @default.
• W4366371546 hasRelatedWork W4249414561 @default.
• W4366371546 isParatext "false" @default.
• W4366371546 isRetracted "false" @default.
• W4366371546 workType "article" @default.