FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366372199> ?p ?o ?g. }

• W4366372199 endingPage "3284" @default.
• W4366372199 startingPage "3275" @default.
• W4366372199 abstract "Schmallenberg Virus (SBV), an arbovirus from the Peribunyaviridae family and Orthobunyavirus genus, was discovered in late 2011 in Germany and has been circulating in Europe, Asia and Africa ever since. The virus causes a disease associated with ruminants that includes fever, fetal malformation, drop in milk production, diarrhoea and stillbirths, becoming a burden for small and large farms. Building on previous studies on SBV nucleoprotein (SBV-N) as a promising vaccine candidate, we have investigated the possible protein regions responsible for protection. Based on selective truncation of domains designed from the available crystal structure of the SBV-N, we identified both the N-terminal domain (N-term; Met1 – Thr133) and a smaller fragment within (C4; Met1 – Ala58) as vaccine prototypes. Two injections of the N-term and C4 polypeptides protected mice knockout for type I interferon (IFN) receptors (IFNAR-/-) challenged with virulent SBV, opposite to control groups that presented severe signs of morbidity and weight loss. Viremia analyses along with the presence of IFN-γ secreted from splenocytes re-stimulated with the N-terminal region of the protein corroborate that these two portions of SBV-N can be employed as subunit vaccines. Apart from both proteinaceous fragments being easily produced in bacterial cells, the C4 polypeptide shares a high sequence homology (∼87.1 %) with the corresponding region of nucleoproteins of several viruses of the Simbu serogroup, a group of Orthobunyaviruses that comprises SBV and veterinary pathogens like Akabane virus and human infecting viruses like Oropouche. Thus, we propose that this smaller fragment is better suited for vaccine nanoparticle formulation, and it paves the way to further research with other related Orthobunyaviruses." @default.
• W4366372199 created "2023-04-21" @default.
• W4366372199 creator A5028929113 @default.
• W4366372199 creator A5035132441 @default.
• W4366372199 creator A5042709709 @default.
• W4366372199 creator A5048087932 @default.
• W4366372199 creator A5051915794 @default.
• W4366372199 creator A5063310362 @default.
• W4366372199 creator A5087401614 @default.
• W4366372199 date "2023-05-01" @default.
• W4366372199 modified "2023-10-14" @default.
• W4366372199 title "Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces viremia in SBV challenged IFNAR-/- mice" @default.
• W4366372199 cites W1964693934 @default.
• W4366372199 cites W1968391995 @default.
• W4366372199 cites W1979503818 @default.
• W4366372199 cites W2031249009 @default.
• W4366372199 cites W2038047938 @default.
• W4366372199 cites W2047018918 @default.
• W4366372199 cites W2047142803 @default.
• W4366372199 cites W2076787697 @default.
• W4366372199 cites W2091922384 @default.
• W4366372199 cites W2094403474 @default.
• W4366372199 cites W2099283585 @default.
• W4366372199 cites W2106882534 @default.
• W4366372199 cites W2123432782 @default.
• W4366372199 cites W2132081049 @default.
• W4366372199 cites W2134855545 @default.
• W4366372199 cites W2141310340 @default.
• W4366372199 cites W2144340783 @default.
• W4366372199 cites W2157024427 @default.
• W4366372199 cites W2168974130 @default.
• W4366372199 cites W2172319351 @default.
• W4366372199 cites W2284649876 @default.
• W4366372199 cites W2432086212 @default.
• W4366372199 cites W2530639866 @default.
• W4366372199 cites W2588563719 @default.
• W4366372199 cites W2591529548 @default.
• W4366372199 cites W2607159278 @default.
• W4366372199 cites W2776593701 @default.
• W4366372199 cites W2883434324 @default.
• W4366372199 cites W2883446746 @default.
• W4366372199 cites W2915836908 @default.
• W4366372199 cites W2991200403 @default.
• W4366372199 cites W3009504476 @default.
• W4366372199 cites W3010170669 @default.
• W4366372199 cites W3017221947 @default.
• W4366372199 cites W3033251405 @default.
• W4366372199 cites W3107951352 @default.
• W4366372199 cites W3160834656 @default.
• W4366372199 cites W4213120203 @default.
• W4366372199 cites W4214809401 @default.
• W4366372199 cites W4231020215 @default.
• W4366372199 cites W4292259364 @default.
• W4366372199 doi "https://doi.org/10.1016/j.vaccine.2023.04.027" @default.
• W4366372199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37085455" @default.
• W4366372199 hasPublicationYear "2023" @default.
• W4366372199 type Work @default.
• W4366372199 citedByCount "0" @default.
• W4366372199 crossrefType "journal-article" @default.
• W4366372199 hasAuthorship W4366372199A5028929113 @default.
• W4366372199 hasAuthorship W4366372199A5035132441 @default.
• W4366372199 hasAuthorship W4366372199A5042709709 @default.
• W4366372199 hasAuthorship W4366372199A5048087932 @default.
• W4366372199 hasAuthorship W4366372199A5051915794 @default.
• W4366372199 hasAuthorship W4366372199A5063310362 @default.
• W4366372199 hasAuthorship W4366372199A5087401614 @default.
• W4366372199 hasBestOaLocation W43663721991 @default.
• W4366372199 hasConcept C159047783 @default.
• W4366372199 hasConcept C2522874641 @default.
• W4366372199 hasConcept C2776185481 @default.
• W4366372199 hasConcept C2778706330 @default.
• W4366372199 hasConcept C60325843 @default.
• W4366372199 hasConcept C86803240 @default.
• W4366372199 hasConceptScore W4366372199C159047783 @default.
• W4366372199 hasConceptScore W4366372199C2522874641 @default.
• W4366372199 hasConceptScore W4366372199C2776185481 @default.
• W4366372199 hasConceptScore W4366372199C2778706330 @default.
• W4366372199 hasConceptScore W4366372199C60325843 @default.
• W4366372199 hasConceptScore W4366372199C86803240 @default.
• W4366372199 hasIssue "20" @default.
• W4366372199 hasLocation W43663721991 @default.
• W4366372199 hasLocation W43663721992 @default.
• W4366372199 hasLocation W43663721993 @default.
• W4366372199 hasOpenAccess W4366372199 @default.
• W4366372199 hasPrimaryLocation W43663721991 @default.
• W4366372199 hasRelatedWork W1590027774 @default.
• W4366372199 hasRelatedWork W1933588764 @default.
• W4366372199 hasRelatedWork W1989353793 @default.
• W4366372199 hasRelatedWork W2057745002 @default.
• W4366372199 hasRelatedWork W2082080978 @default.
• W4366372199 hasRelatedWork W2150845218 @default.
• W4366372199 hasRelatedWork W2151148014 @default.
• W4366372199 hasRelatedWork W2313303031 @default.
• W4366372199 hasRelatedWork W2410516265 @default.
• W4366372199 hasRelatedWork W2591529548 @default.
• W4366372199 hasVolume "41" @default.
• W4366372199 isParatext "false" @default.
• W4366372199 isRetracted "false" @default.

• next