Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366385265> ?p ?o ?g. }
- W4366385265 endingPage "224" @default.
- W4366385265 startingPage "214" @default.
- W4366385265 abstract "Atopic Dermatitis (AD) is a chronic inflammatory skin disorder with evidence of lichenification in later stages. There is mounting evidence supporting the role of TGF- β1 in mediating inflammation as well as subsequent tissue remodeling, often resulting in fibrosis. Given the role of genetic variants in the differential expression of TGF-β1 in various diseases, this study seeks to ascertain the role of TGF-β1 promoter variants (rs1800469 and rs1800468) in AD susceptibility, as well as their association with TGF- β1 mRNA expression, TGF- β1 serum levels and skin prick test positivity in Atopic Dermatitis patients.An aggregate of 246 subjects including 134 AD cases and 112 matched healthy controls were genotyped for TGF-β1 promoter polymorphisms by PCR-RFLP. TGF- β1 mRNA was quantified by quantitative Real-Time PCR (qRT-PCR), Vitamin-D levels by chemiluminescence, and serum TGF- β1, and total IgE levels were determined by ELISA. In-vivo allergy testing was performed for the evaluation of allergic reactions to house dust mites and food allergens.A higher frequency of TT genotypes of rs1800469 (OR = 7.7, p = 0.0001) and GA+AA genotypes of rs1800468 (OR-4.4, p < 0.0001) were observed in AD cases than those in controls. Haplotype analysis demonstrated that TG haplotype carriers had an increased risk of AD (p = 0.013). Quantitative analysis revealed a significant upregulation of both mRNA (p = 0.0002) and serum levels (p < 0.0001) of TGF- β1 with a substantial positive correlation between them (Correlation coefficient=0.504; p = 0.01). Moreover, serum TGF-β1 levels were associated with quality of life (p = 0.03), the severity of the disease (p = 0.03), and House dust mite allergy (p = 0.01) whereas TGF-β1 mRNA levels positively correlated with disease severity(p = 0.02). Stratification analysis revealed that the TT genotype of rs1800469 was associated with higher IgE levels (p = 0.01) and eosinophil percentage(p = 0.007) whereas the AA genotype of rs1800468 correlated with elevated serum IgE levels (p = 0.01). Besides, no significant association of genotypes with mRNA and serum expression of TGF-β1 was observed.Our study indicates that TGF-β1 promoter SNPs bear a significant risk of AD development. Moreover, upregulation of TGF-β1 mRNA and serum levels and their association with disease severity, quality of life, and HDM allergy suggests its role as a diagnostic/prognostic biomarker that could help in the development of new therapeutic and prevention strategies." @default.
- W4366385265 created "2023-04-21" @default.
- W4366385265 creator A5007419864 @default.
- W4366385265 creator A5019154039 @default.
- W4366385265 creator A5021678805 @default.
- W4366385265 creator A5025855290 @default.
- W4366385265 creator A5028937921 @default.
- W4366385265 creator A5044409933 @default.
- W4366385265 creator A5056604647 @default.
- W4366385265 creator A5064564796 @default.
- W4366385265 creator A5085628848 @default.
- W4366385265 creator A5091204752 @default.
- W4366385265 date "2023-05-01" @default.
- W4366385265 modified "2023-09-27" @default.
- W4366385265 title "Unveiling the TGF- β1 paradox: Significant implication of TGF- β1 promoter variants and its mRNA and protein expression in atopic dermatitis" @default.
- W4366385265 cites W1508394416 @default.
- W4366385265 cites W1528120845 @default.
- W4366385265 cites W1577577364 @default.
- W4366385265 cites W1839043230 @default.
- W4366385265 cites W1921416115 @default.
- W4366385265 cites W1969835992 @default.
- W4366385265 cites W1971402668 @default.
- W4366385265 cites W1971443537 @default.
- W4366385265 cites W1977882279 @default.
- W4366385265 cites W1987492687 @default.
- W4366385265 cites W2005895346 @default.
- W4366385265 cites W2010011258 @default.
- W4366385265 cites W2022137053 @default.
- W4366385265 cites W2024704568 @default.
- W4366385265 cites W2026125421 @default.
- W4366385265 cites W2034508361 @default.
- W4366385265 cites W2051521434 @default.
- W4366385265 cites W2065059030 @default.
- W4366385265 cites W2069443154 @default.
- W4366385265 cites W2072025288 @default.
- W4366385265 cites W2073243488 @default.
- W4366385265 cites W2096991001 @default.
- W4366385265 cites W2098080621 @default.
- W4366385265 cites W2107792698 @default.
- W4366385265 cites W2116824990 @default.
- W4366385265 cites W2126352920 @default.
- W4366385265 cites W2131462541 @default.
- W4366385265 cites W2134427614 @default.
- W4366385265 cites W2146302565 @default.
- W4366385265 cites W2165178639 @default.
- W4366385265 cites W2165933909 @default.
- W4366385265 cites W2166382188 @default.
- W4366385265 cites W2217868403 @default.
- W4366385265 cites W2474553364 @default.
- W4366385265 cites W2529210671 @default.
- W4366385265 cites W2560095365 @default.
- W4366385265 cites W2560512845 @default.
- W4366385265 cites W2604249065 @default.
- W4366385265 cites W2608505294 @default.
- W4366385265 cites W2770083058 @default.
- W4366385265 cites W2782004213 @default.
- W4366385265 cites W2800832357 @default.
- W4366385265 cites W2940853643 @default.
- W4366385265 cites W2947323924 @default.
- W4366385265 cites W3007757041 @default.
- W4366385265 cites W3089135360 @default.
- W4366385265 cites W3106711225 @default.
- W4366385265 cites W3119334612 @default.
- W4366385265 cites W4205474905 @default.
- W4366385265 cites W4224026742 @default.
- W4366385265 doi "https://doi.org/10.1016/j.molimm.2023.04.006" @default.
- W4366385265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37084506" @default.
- W4366385265 hasPublicationYear "2023" @default.
- W4366385265 type Work @default.
- W4366385265 citedByCount "0" @default.
- W4366385265 crossrefType "journal-article" @default.
- W4366385265 hasAuthorship W4366385265A5007419864 @default.
- W4366385265 hasAuthorship W4366385265A5019154039 @default.
- W4366385265 hasAuthorship W4366385265A5021678805 @default.
- W4366385265 hasAuthorship W4366385265A5025855290 @default.
- W4366385265 hasAuthorship W4366385265A5028937921 @default.
- W4366385265 hasAuthorship W4366385265A5044409933 @default.
- W4366385265 hasAuthorship W4366385265A5056604647 @default.
- W4366385265 hasAuthorship W4366385265A5064564796 @default.
- W4366385265 hasAuthorship W4366385265A5085628848 @default.
- W4366385265 hasAuthorship W4366385265A5091204752 @default.
- W4366385265 hasConcept C104317684 @default.
- W4366385265 hasConcept C105580179 @default.
- W4366385265 hasConcept C118131993 @default.
- W4366385265 hasConcept C126322002 @default.
- W4366385265 hasConcept C134018914 @default.
- W4366385265 hasConcept C135763542 @default.
- W4366385265 hasConcept C141105273 @default.
- W4366385265 hasConcept C159654299 @default.
- W4366385265 hasConcept C197754878 @default.
- W4366385265 hasConcept C203014093 @default.
- W4366385265 hasConcept C207480886 @default.
- W4366385265 hasConcept C2776914184 @default.
- W4366385265 hasConcept C2778329239 @default.
- W4366385265 hasConcept C2779675166 @default.
- W4366385265 hasConcept C2780559512 @default.
- W4366385265 hasConcept C2909639559 @default.
- W4366385265 hasConcept C54355233 @default.