FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366385296> ?p ?o ?g. }

• W4366385296 endingPage "100764" @default.
• W4366385296 startingPage "100764" @default.
• W4366385296 abstract "Mounting literatures suggest that follicular fluid-derived exosomes (FF-Evs) influence the progression of progression of polycystic ovary syndrome (PCOS). The present study was designed to dissect the underlying mechanisms by which FF-Evs affect the PCOS. A rat model of PCOS was established using Letrozole induction. After treatment with FF-Evs, rats were examined for alterations in hormones, blood glucose, and lipid levels in serum, oestrus cycle, pathology in the ovaries, and apoptosis of ovarian cells. The functional rescue assays were performed to analyze the impact of long non-coding RNA 00092 (LINC00092) on PCOS rats. The cis-regulatory elements involved in the regulation of phosphatase and tensin homolog (PTEN) expression were analyzed using bioinformatic analysis, followed by verification of the mechanism. FF-Evs treatment ameliorated Letrozole-induced enhancement of weight, insulin resistance, dyslipidemia, and LH/FSH ratio, reduction of luteal cells, granulosa cells, and healthy follicles, prolonged oestrus, oestrous cycle arrest, ovarian tissue fibrosis, and ovarian cell apoptosis in rats, which were counteracted by treatment with shRNA targeting LINC00092. Regarding the mechanism, FF-Evs augmented LINC00092 expression in rats. LINC00092 bound to lysine demethylase 5 A (KDM5A), and KDM5A facilitated the demethylation of H3K4me3 to restrain the transcriptional activity of PTEN. Taken together, FF-Evs delivered LINC00092 repressed the transcriptional activity of PTEN by binding to KDM5A to enhance demethylation of H3K4me3, thereby reducing apoptosis in ovarian cells and alleviating PCOS symptoms." @default.
• W4366385296 created "2023-04-21" @default.
• W4366385296 creator A5019793023 @default.
• W4366385296 creator A5033108164 @default.
• W4366385296 creator A5045703368 @default.
• W4366385296 creator A5057516291 @default.
• W4366385296 creator A5057993601 @default.
• W4366385296 creator A5064222660 @default.
• W4366385296 creator A5070504833 @default.
• W4366385296 creator A5083164193 @default.
• W4366385296 creator A5088093959 @default.
• W4366385296 creator A5091660651 @default.
• W4366385296 date "2023-06-01" @default.
• W4366385296 modified "2023-10-12" @default.
• W4366385296 title "LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A" @default.
• W4366385296 cites W1824982875 @default.
• W4366385296 cites W2054964677 @default.
• W4366385296 cites W2572346489 @default.
• W4366385296 cites W2949825098 @default.
• W4366385296 cites W2966981559 @default.
• W4366385296 cites W2989778925 @default.
• W4366385296 cites W3004163626 @default.
• W4366385296 cites W3007347600 @default.
• W4366385296 cites W3024067802 @default.
• W4366385296 cites W3041901244 @default.
• W4366385296 cites W3047352808 @default.
• W4366385296 cites W3047467770 @default.
• W4366385296 cites W3080416416 @default.
• W4366385296 cites W3094083846 @default.
• W4366385296 cites W3157212237 @default.
• W4366385296 cites W3159849666 @default.
• W4366385296 cites W3203672909 @default.
• W4366385296 cites W3212246792 @default.
• W4366385296 cites W4210762533 @default.
• W4366385296 cites W4212912412 @default.
• W4366385296 cites W4220986213 @default.
• W4366385296 cites W4229371139 @default.
• W4366385296 doi "https://doi.org/10.1016/j.repbio.2023.100764" @default.
• W4366385296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37084543" @default.
• W4366385296 hasPublicationYear "2023" @default.
• W4366385296 type Work @default.
• W4366385296 citedByCount "1" @default.
• W4366385296 countsByYear W43663852962023 @default.
• W4366385296 crossrefType "journal-article" @default.
• W4366385296 hasAuthorship W4366385296A5019793023 @default.
• W4366385296 hasAuthorship W4366385296A5033108164 @default.
• W4366385296 hasAuthorship W4366385296A5045703368 @default.
• W4366385296 hasAuthorship W4366385296A5057516291 @default.
• W4366385296 hasAuthorship W4366385296A5057993601 @default.
• W4366385296 hasAuthorship W4366385296A5064222660 @default.
• W4366385296 hasAuthorship W4366385296A5070504833 @default.
• W4366385296 hasAuthorship W4366385296A5083164193 @default.
• W4366385296 hasAuthorship W4366385296A5088093959 @default.
• W4366385296 hasAuthorship W4366385296A5091660651 @default.
• W4366385296 hasConcept C126322002 @default.
• W4366385296 hasConcept C134018914 @default.
• W4366385296 hasConcept C187785154 @default.
• W4366385296 hasConcept C190283241 @default.
• W4366385296 hasConcept C196843134 @default.
• W4366385296 hasConcept C2776188440 @default.
• W4366385296 hasConcept C2776690073 @default.
• W4366385296 hasConcept C2777609662 @default.
• W4366385296 hasConcept C2779549131 @default.
• W4366385296 hasConcept C502942594 @default.
• W4366385296 hasConcept C55493867 @default.
• W4366385296 hasConcept C71924100 @default.
• W4366385296 hasConcept C86554907 @default.
• W4366385296 hasConcept C86803240 @default.
• W4366385296 hasConcept C95444343 @default.
• W4366385296 hasConceptScore W4366385296C126322002 @default.
• W4366385296 hasConceptScore W4366385296C134018914 @default.
• W4366385296 hasConceptScore W4366385296C187785154 @default.
• W4366385296 hasConceptScore W4366385296C190283241 @default.
• W4366385296 hasConceptScore W4366385296C196843134 @default.
• W4366385296 hasConceptScore W4366385296C2776188440 @default.
• W4366385296 hasConceptScore W4366385296C2776690073 @default.
• W4366385296 hasConceptScore W4366385296C2777609662 @default.
• W4366385296 hasConceptScore W4366385296C2779549131 @default.
• W4366385296 hasConceptScore W4366385296C502942594 @default.
• W4366385296 hasConceptScore W4366385296C55493867 @default.
• W4366385296 hasConceptScore W4366385296C71924100 @default.
• W4366385296 hasConceptScore W4366385296C86554907 @default.
• W4366385296 hasConceptScore W4366385296C86803240 @default.
• W4366385296 hasConceptScore W4366385296C95444343 @default.
• W4366385296 hasIssue "2" @default.
• W4366385296 hasLocation W43663852961 @default.
• W4366385296 hasLocation W43663852962 @default.
• W4366385296 hasOpenAccess W4366385296 @default.
• W4366385296 hasPrimaryLocation W43663852961 @default.
• W4366385296 hasRelatedWork W1993617954 @default.
• W4366385296 hasRelatedWork W1997084308 @default.
• W4366385296 hasRelatedWork W2020430997 @default.
• W4366385296 hasRelatedWork W2035816313 @default.
• W4366385296 hasRelatedWork W2379132232 @default.
• W4366385296 hasRelatedWork W2809156896 @default.
• W4366385296 hasRelatedWork W3015303018 @default.
• W4366385296 hasRelatedWork W4287485429 @default.
• W4366385296 hasRelatedWork W4319242539 @default.

• next