FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366389631> ?p ?o ?g. }

• W4366389631 endingPage "7064" @default.
• W4366389631 startingPage "7055" @default.
• W4366389631 abstract "8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) is a crucial biomarker of oxidative DNA damage. Herein, a highly sensitive fluorescent aptasensor for detecting 8-oxo-dG in urine was developed based on aptamer-mediated quenching of amino-terminated oligo(ethylene glycol)-capped gold nanoparticles (NH2-TEG-AuNPs) toward green emissive carbon dots (G-CDs). G-CDs were employed as fluorometric reporters. Upon addition of 8-oxo-dG, it formed a complex with an anti-8-oxo-dG aptamer, resulting in the quenching of fluorescence as NH2-TEG-AuNPs absorbed the emission from G-CDs. Initially, NH2-TEG-AuNPs suppressed the fluorescence intensity of G-CDs via the inner-filter effect (IFE). With the addition of the aptamers to a mixture of G-CDs and NH2-TEG-AuNPs, the electrostatic interactions between the aptamer and NH2-TEG-AuNPs resulted in the aggregation of NH2-TEG-AuNPs and the recovery of the fluorescence intensity of the quenched G-CDs. NH2-TEG-AuNPs dispersed due to the high affinity between the aptamer and 8-oxo-dG molecules, and the system demonstrated a fluorescence ″turn-off″ response of G-CDs. Thus, it was possible to determine the 8-oxo-dG concentration. A fluorescence calibration curve was constructed with two linear ranges: 100–2000 and 2000–10,000 nM. The limit of detection (LOD) for 8-oxo-dG was 15.89 nM. This approach was successfully applied to assess 8-oxo-dG in synthetic urine samples with mean recoveries ranging from 99 to 120% and relative standard deviations (RSDs) between 1.1 and 4.1%. The analytical performance was comparable to a commercially available enzyme-linked immunosorbent assay (ELISA) kit. This proposed fluorescent aptasensor for 8-oxo-dG detection in urine exhibited high selectivity and sensitivity over a broad concentration range against the target molecule and has the potential to be developed as a new platform for rapid screening of 8-oxo-dG." @default.
• W4366389631 created "2023-04-21" @default.
• W4366389631 creator A5003272592 @default.
• W4366389631 creator A5027668671 @default.
• W4366389631 creator A5061208000 @default.
• W4366389631 creator A5068163338 @default.
• W4366389631 creator A5071001042 @default.
• W4366389631 creator A5076196444 @default.
• W4366389631 creator A5091668800 @default.
• W4366389631 date "2023-04-19" @default.
• W4366389631 modified "2023-10-16" @default.
• W4366389631 title "Fluorescent Aptasensor for Determination of 8-Oxo-2′-deoxyguanosine in Urine Using Carbon Dots and Amine-Functionalized Gold Nanoparticles" @default.
• W4366389631 cites W1579958623 @default.
• W4366389631 cites W1812420556 @default.
• W4366389631 cites W1959376152 @default.
• W4366389631 cites W1964774511 @default.
• W4366389631 cites W1968241717 @default.
• W4366389631 cites W1969632448 @default.
• W4366389631 cites W1970286597 @default.
• W4366389631 cites W1971160376 @default.
• W4366389631 cites W1978295772 @default.
• W4366389631 cites W1992769383 @default.
• W4366389631 cites W1997854795 @default.
• W4366389631 cites W2000364878 @default.
• W4366389631 cites W2010962252 @default.
• W4366389631 cites W2044440155 @default.
• W4366389631 cites W2049073341 @default.
• W4366389631 cites W2049690540 @default.
• W4366389631 cites W2058023177 @default.
• W4366389631 cites W2075846407 @default.
• W4366389631 cites W2077694961 @default.
• W4366389631 cites W2091179627 @default.
• W4366389631 cites W2310566030 @default.
• W4366389631 cites W2431098894 @default.
• W4366389631 cites W2464989486 @default.
• W4366389631 cites W2509538052 @default.
• W4366389631 cites W2512975892 @default.
• W4366389631 cites W2588221624 @default.
• W4366389631 cites W2588278653 @default.
• W4366389631 cites W2604463251 @default.
• W4366389631 cites W2757087557 @default.
• W4366389631 cites W2765571615 @default.
• W4366389631 cites W2770115942 @default.
• W4366389631 cites W2770598806 @default.
• W4366389631 cites W2782249334 @default.
• W4366389631 cites W2786700749 @default.
• W4366389631 cites W2789180267 @default.
• W4366389631 cites W2789863800 @default.
• W4366389631 cites W2804352031 @default.
• W4366389631 cites W2807198354 @default.
• W4366389631 cites W2857884153 @default.
• W4366389631 cites W2887993387 @default.
• W4366389631 cites W2891526668 @default.
• W4366389631 cites W2891828739 @default.
• W4366389631 cites W2904808692 @default.
• W4366389631 cites W2905229296 @default.
• W4366389631 cites W2906982060 @default.
• W4366389631 cites W2909990552 @default.
• W4366389631 cites W2916643620 @default.
• W4366389631 cites W2932924290 @default.
• W4366389631 cites W2943902911 @default.
• W4366389631 cites W2948756851 @default.
• W4366389631 cites W2955634568 @default.
• W4366389631 cites W2962208185 @default.
• W4366389631 cites W2978801762 @default.
• W4366389631 cites W2989843589 @default.
• W4366389631 cites W2999591110 @default.
• W4366389631 cites W3001320345 @default.
• W4366389631 cites W3015514217 @default.
• W4366389631 cites W3028663147 @default.
• W4366389631 cites W3038149747 @default.
• W4366389631 cites W3041309870 @default.
• W4366389631 cites W3081652158 @default.
• W4366389631 cites W3088424047 @default.
• W4366389631 cites W3088431909 @default.
• W4366389631 cites W3112666381 @default.
• W4366389631 cites W3180502960 @default.
• W4366389631 cites W4206472884 @default.
• W4366389631 cites W4281987353 @default.
• W4366389631 cites W4294873890 @default.
• W4366389631 cites W4306939094 @default.
• W4366389631 cites W4307114399 @default.
• W4366389631 doi "https://doi.org/10.1021/acsanm.3c01238" @default.
• W4366389631 hasPublicationYear "2023" @default.
• W4366389631 type Work @default.
• W4366389631 citedByCount "0" @default.
• W4366389631 crossrefType "journal-article" @default.
• W4366389631 hasAuthorship W4366389631A5003272592 @default.
• W4366389631 hasAuthorship W4366389631A5027668671 @default.
• W4366389631 hasAuthorship W4366389631A5061208000 @default.
• W4366389631 hasAuthorship W4366389631A5068163338 @default.
• W4366389631 hasAuthorship W4366389631A5071001042 @default.
• W4366389631 hasAuthorship W4366389631A5076196444 @default.
• W4366389631 hasAuthorship W4366389631A5091668800 @default.
• W4366389631 hasConcept C104819515 @default.
• W4366389631 hasConcept C113196181 @default.
• W4366389631 hasConcept C119128265 @default.
• W4366389631 hasConcept C121332964 @default.

• next