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- W4366392956 endingPage "7450" @default.
- W4366392956 startingPage "7450" @default.
- W4366392956 abstract "The reprogramming of metabolism is a recognized cancer hallmark. It is well known that different signaling pathways regulate and orchestrate this reprogramming that contributes to cancer initiation and development. However, recent evidence is accumulating, suggesting that several metabolites could play a relevant role in regulating signaling pathways. To assess the potential role of metabolites in the regulation of signaling pathways, both metabolic and signaling pathway activities of Breast invasive Carcinoma (BRCA) have been modeled using mechanistic models. Gaussian Processes, powerful machine learning methods, were used in combination with SHapley Additive exPlanations (SHAP), a recent methodology that conveys causality, to obtain potential causal relationships between the production of metabolites and the regulation of signaling pathways. A total of 317 metabolites were found to have a strong impact on signaling circuits. The results presented here point to the existence of a complex crosstalk between signaling and metabolic pathways more complex than previously was thought." @default.
- W4366392956 created "2023-04-21" @default.
- W4366392956 creator A5021802977 @default.
- W4366392956 creator A5067601660 @default.
- W4366392956 creator A5068809376 @default.
- W4366392956 creator A5081433623 @default.
- W4366392956 date "2023-04-18" @default.
- W4366392956 modified "2023-10-06" @default.
- W4366392956 title "Crosstalk between Metabolite Production and Signaling Activity in Breast Cancer" @default.
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