FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366393498> ?p ?o ?g. }

• W4366393498 abstract "Background Immunogenic cell death (ICD) is a form of cell death that elicits immune responses against the antigens found in dead or dying tumor cells. Growing evidence implies that ICD plays a significant role in triggering antitumor immunity. The prognosis for glioma remains poor despite many biomarkers being reported, and identifying ICD-related biomarkers is imminent for better-personalized management in patients with lower-grade glioma (LGG). Materials and methods We identified ICD-related differentially expressed genes (DEGs) by comparing gene expression profiles obtained across Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) cohorts. On the foundation of ICD-related DEGs, two ICD-related clusters were identified through consensus clustering. Then, survival analysis, functional enrichment analysis, somatic mutation analysis, and immune characteristics analysis were performed in the two ICD-related subtypes. Additionally, we developed and validated a risk assessment signature for LGG patients. Finally, we selected one gene (EIF2AK3) from the above risk model for experimental validation. Results 32 ICD-related DEGs were screened, dividing the LGG samples from the TCGA database into two distinct subtypes. The ICD-high subgroup showed worse overall survival (OS), greater immune infiltration, more active immune response process, and higher expression levels of HLA genes than the ICD-low subgroup. Additionally, nine ICD-related DEGs were identified to build the prognostic signature, which was highly correlated with the tumor-immune microenvironment and could unambiguously be taken as an independent prognostic factor and further verified in an external dataset. The experimental results indicated that EIF2AK3 expression was higher in tumors than paracancerous tissues, and high-expression EIF2AK3 was enriched in WHO III and IV gliomas by qPCR and IHC, and Knockdown of EIF2AK3 suppressed cell viability and mobility in glioma cells. Conclusion We established novel ICD-related subtypes and risk signature for LGG, which may be beneficial to improving clinical outcome prediction and guiding individualized immunotherapy." @default.
• W4366393498 created "2023-04-21" @default.
• W4366393498 creator A5011065863 @default.
• W4366393498 creator A5018583903 @default.
• W4366393498 creator A5023720152 @default.
• W4366393498 creator A5076573585 @default.
• W4366393498 creator A5083054807 @default.
• W4366393498 creator A5085039487 @default.
• W4366393498 creator A5086915647 @default.
• W4366393498 creator A5087874502 @default.
• W4366393498 creator A5090662503 @default.
• W4366393498 date "2023-04-19" @default.
• W4366393498 modified "2023-10-16" @default.
• W4366393498 title "Classification related to immunogenic cell death predicts prognosis, immune microenvironment characteristics, and response to immunotherapy in lower-grade gliomas" @default.
• W4366393498 cites W1860764269 @default.
• W4366393498 cites W1985987855 @default.
• W4366393498 cites W2015814422 @default.
• W4366393498 cites W2035618305 @default.
• W4366393498 cites W2044528599 @default.
• W4366393498 cites W2044685551 @default.
• W4366393498 cites W2091690982 @default.
• W4366393498 cites W2120426523 @default.
• W4366393498 cites W2123106337 @default.
• W4366393498 cites W2130410032 @default.
• W4366393498 cites W2148977460 @default.
• W4366393498 cites W2154576630 @default.
• W4366393498 cites W2254632051 @default.
• W4366393498 cites W2284101226 @default.
• W4366393498 cites W2591639353 @default.
• W4366393498 cites W2624114007 @default.
• W4366393498 cites W2758629197 @default.
• W4366393498 cites W2788640168 @default.
• W4366393498 cites W2791087181 @default.
• W4366393498 cites W2791925378 @default.
• W4366393498 cites W2809949045 @default.
• W4366393498 cites W2875832027 @default.
• W4366393498 cites W2900569176 @default.
• W4366393498 cites W2902353350 @default.
• W4366393498 cites W2913928134 @default.
• W4366393498 cites W2917058676 @default.
• W4366393498 cites W2962737634 @default.
• W4366393498 cites W2970204123 @default.
• W4366393498 cites W2980389798 @default.
• W4366393498 cites W3031816528 @default.
• W4366393498 cites W3045772015 @default.
• W4366393498 cites W3049387264 @default.
• W4366393498 cites W3104958039 @default.
• W4366393498 cites W3109736879 @default.
• W4366393498 cites W3129222377 @default.
• W4366393498 cites W3131198922 @default.
• W4366393498 cites W3135035839 @default.
• W4366393498 cites W3145606418 @default.
• W4366393498 cites W3152447517 @default.
• W4366393498 cites W3176044048 @default.
• W4366393498 cites W3185961452 @default.
• W4366393498 cites W3195341596 @default.
• W4366393498 cites W3203797662 @default.
• W4366393498 cites W4200327950 @default.
• W4366393498 cites W4205747108 @default.
• W4366393498 cites W4211050477 @default.
• W4366393498 cites W4225248620 @default.
• W4366393498 cites W4280644150 @default.
• W4366393498 cites W4281914699 @default.
• W4366393498 cites W4293206835 @default.
• W4366393498 cites W4306879831 @default.
• W4366393498 cites W4318025744 @default.
• W4366393498 doi "https://doi.org/10.3389/fimmu.2023.1102094" @default.
• W4366393498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37153540" @default.
• W4366393498 hasPublicationYear "2023" @default.
• W4366393498 type Work @default.
• W4366393498 citedByCount "2" @default.
• W4366393498 countsByYear W43663934982023 @default.
• W4366393498 crossrefType "journal-article" @default.
• W4366393498 hasAuthorship W4366393498A5011065863 @default.
• W4366393498 hasAuthorship W4366393498A5018583903 @default.
• W4366393498 hasAuthorship W4366393498A5023720152 @default.
• W4366393498 hasAuthorship W4366393498A5076573585 @default.
• W4366393498 hasAuthorship W4366393498A5083054807 @default.
• W4366393498 hasAuthorship W4366393498A5085039487 @default.
• W4366393498 hasAuthorship W4366393498A5086915647 @default.
• W4366393498 hasAuthorship W4366393498A5087874502 @default.
• W4366393498 hasAuthorship W4366393498A5090662503 @default.
• W4366393498 hasConcept C10515644 @default.
• W4366393498 hasConcept C126322002 @default.
• W4366393498 hasConcept C143998085 @default.
• W4366393498 hasConcept C203014093 @default.
• W4366393498 hasConcept C2776107976 @default.
• W4366393498 hasConcept C2777701055 @default.
• W4366393498 hasConcept C2778227246 @default.
• W4366393498 hasConcept C502942594 @default.
• W4366393498 hasConcept C71924100 @default.
• W4366393498 hasConcept C86803240 @default.
• W4366393498 hasConcept C8891405 @default.
• W4366393498 hasConceptScore W4366393498C10515644 @default.
• W4366393498 hasConceptScore W4366393498C126322002 @default.
• W4366393498 hasConceptScore W4366393498C143998085 @default.
• W4366393498 hasConceptScore W4366393498C203014093 @default.
• W4366393498 hasConceptScore W4366393498C2776107976 @default.
• W4366393498 hasConceptScore W4366393498C2777701055 @default.
• W4366393498 hasConceptScore W4366393498C2778227246 @default.

• next